Associations between serum copper, zinc, selenium level and sex hormones among 6–19 years old children and adolescents in NHANES 2013–2016
Copper, zinc, and selenium are essential trace elements for human and have important effects on sex hormones. There are few studies on the relationships between the three trace elements and sex hormones. Therefore, our study aimed to investigate the relationships between serum copper, zinc, selenium...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.924338/full |
| _version_ | 1811273418639671296 |
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| author | Lishun Xiao Lishun Xiao Lishun Xiao Chengcheng Yang Wen Gu Rong Liu Rong Liu Rong Liu Ding Chen |
| author_facet | Lishun Xiao Lishun Xiao Lishun Xiao Chengcheng Yang Wen Gu Rong Liu Rong Liu Rong Liu Ding Chen |
| author_sort | Lishun Xiao |
| collection | DOAJ |
| description | Copper, zinc, and selenium are essential trace elements for human and have important effects on sex hormones. There are few studies on the relationships between the three trace elements and sex hormones. Therefore, our study aimed to investigate the relationships between serum copper, zinc, selenium and testosterone, estradiol, SHBG using data from the National Health and Nutrition Examination Survey (NHANES) 2013-2016 in participants 6-19 years. 1097 participants were enrolled and stratified into male/female children and adolescents. Weighted linear regression models combined regression diagnosis were used to estimate the relationships between trace elements and sex hormones according to the different stratifications. Our results showed that copper was inversely associated with testosterone and estradiol but positively correlated with SHBG. Zinc had positive relationships with testosterone in male adolescents and female children but an inverse relationship with testosterone in female adolescents. Furthermore, a negative association was observed between zinc and SHBG. With the rise of selenium level, testosterone and estradiol were increased but SHBG was decreased. In general, this study used more standardized statistical methods to investigate the relationships between copper, zinc, selenium and testosterone, estradiol, SHBG. Further study should pay attention to some details in statistical methods. |
| first_indexed | 2024-04-12T22:58:48Z |
| format | Article |
| id | doaj.art-2940669824e4436c8fd036b1d4706bf5 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T22:58:48Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2940669824e4436c8fd036b1d4706bf52022-12-22T03:13:06ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-09-011310.3389/fendo.2022.924338924338Associations between serum copper, zinc, selenium level and sex hormones among 6–19 years old children and adolescents in NHANES 2013–2016Lishun Xiao0Lishun Xiao1Lishun Xiao2Chengcheng Yang3Wen Gu4Rong Liu5Rong Liu6Rong Liu7Ding Chen8Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, ChinaCenter for Medical Statistics and Data Analysis, Xuzhou Medical University, Xuzhou, ChinaKey Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou, ChinaThe Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, ChinaCenter for Medical Statistics and Data Analysis, Xuzhou Medical University, Xuzhou, ChinaKey Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou, ChinaSchool of medical information and engineering, Xuzhou Medical University, Xuzhou, ChinaCopper, zinc, and selenium are essential trace elements for human and have important effects on sex hormones. There are few studies on the relationships between the three trace elements and sex hormones. Therefore, our study aimed to investigate the relationships between serum copper, zinc, selenium and testosterone, estradiol, SHBG using data from the National Health and Nutrition Examination Survey (NHANES) 2013-2016 in participants 6-19 years. 1097 participants were enrolled and stratified into male/female children and adolescents. Weighted linear regression models combined regression diagnosis were used to estimate the relationships between trace elements and sex hormones according to the different stratifications. Our results showed that copper was inversely associated with testosterone and estradiol but positively correlated with SHBG. Zinc had positive relationships with testosterone in male adolescents and female children but an inverse relationship with testosterone in female adolescents. Furthermore, a negative association was observed between zinc and SHBG. With the rise of selenium level, testosterone and estradiol were increased but SHBG was decreased. In general, this study used more standardized statistical methods to investigate the relationships between copper, zinc, selenium and testosterone, estradiol, SHBG. Further study should pay attention to some details in statistical methods.https://www.frontiersin.org/articles/10.3389/fendo.2022.924338/fulltrace elementssex hormonesregression diagnosisNHANESchildren and adolescents |
| spellingShingle | Lishun Xiao Lishun Xiao Lishun Xiao Chengcheng Yang Wen Gu Rong Liu Rong Liu Rong Liu Ding Chen Associations between serum copper, zinc, selenium level and sex hormones among 6–19 years old children and adolescents in NHANES 2013–2016 Frontiers in Endocrinology trace elements sex hormones regression diagnosis NHANES children and adolescents |
| title | Associations between serum copper, zinc, selenium level and sex hormones among 6–19 years old children and adolescents in NHANES 2013–2016 |
| title_full | Associations between serum copper, zinc, selenium level and sex hormones among 6–19 years old children and adolescents in NHANES 2013–2016 |
| title_fullStr | Associations between serum copper, zinc, selenium level and sex hormones among 6–19 years old children and adolescents in NHANES 2013–2016 |
| title_full_unstemmed | Associations between serum copper, zinc, selenium level and sex hormones among 6–19 years old children and adolescents in NHANES 2013–2016 |
| title_short | Associations between serum copper, zinc, selenium level and sex hormones among 6–19 years old children and adolescents in NHANES 2013–2016 |
| title_sort | associations between serum copper zinc selenium level and sex hormones among 6 19 years old children and adolescents in nhanes 2013 2016 |
| topic | trace elements sex hormones regression diagnosis NHANES children and adolescents |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.924338/full |
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