Associations of Combined Lifestyle Factors with MAFLD and the Specific Subtypes in Middle-Aged and Elderly Adults: The Dongfeng-Tongji Cohort Study
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the crucial pathogenesis for intra-hepatic and extra-hepatic diseases, especially in elderly adults. Lifestyle management may be a modifiable cost-effective measure for MAFLD prevention, but the evidence is limited. A total of 23,408 mi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/21/4588 |
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| author | Hongxia Li Zhiqiang Cao Jingxi Li Lei King Zhuangyu Zhang Ying Zhao Siyi Zhang Yajing Song Qian Zhang Liangkai Chen Yuhan Tang Lingling Dai Ping Yao |
| author_facet | Hongxia Li Zhiqiang Cao Jingxi Li Lei King Zhuangyu Zhang Ying Zhao Siyi Zhang Yajing Song Qian Zhang Liangkai Chen Yuhan Tang Lingling Dai Ping Yao |
| author_sort | Hongxia Li |
| collection | DOAJ |
| description | Metabolic dysfunction-associated fatty liver disease (MAFLD) is the crucial pathogenesis for intra-hepatic and extra-hepatic diseases, especially in elderly adults. Lifestyle management may be a modifiable cost-effective measure for MAFLD prevention, but the evidence is limited. A total of 23,408 middle-aged and elderly individuals were included in a longitudinal study from 2008 to 2018. Combined lifestyle scores (range 0–6) were evaluated by BMI, smoking, drinking, diet, physical activity, and sleep. Logistic regression models were used to calculate ORs for the risks of MAFLD and specific subtypes. The mean age of participants was 61.7 years, and 44.5% were men. Compared with poor lifestyle (scores 0–2), ORs (95% CIs) of the ideal lifestyle (scores 5–6) were 0.62 (0.57–0.68) for MAFLD, 0.31 (0.28–0.34) for MAFLD with excess weight and obesity, 0.97 (0.75–1.26) for MAFLD with diabetes, and 0.56 (0.51–0.62) for MAFLD with metabolic dysregulation. Additionally, lifestyle improvement was associated with lower risks of MAFLD (OR, 0.76; 95% CI, 0.68–0.86), MAFLD with excess weight and obesity (OR, 0.72; 95% CI, 0.63–0.81), MAFLD with diabetes (OR, 0.74; 95% CI, 0.54–1.02) and MAFLD with metabolic dysregulation (OR, 0.49; 95% CI, 0.43–0.55), respectively. Our findings suggest that adherence to a combined healthy lifestyle was associated with lower risks of MAFLD, particularly in excess weight/obese individuals or those with metabolic dysregulation. |
| first_indexed | 2024-03-11T11:23:09Z |
| format | Article |
| id | doaj.art-29418d1ffdbd40cfbbcdea421b001635 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T11:23:09Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-29418d1ffdbd40cfbbcdea421b0016352023-11-10T15:09:43ZengMDPI AGNutrients2072-66432023-10-011521458810.3390/nu15214588Associations of Combined Lifestyle Factors with MAFLD and the Specific Subtypes in Middle-Aged and Elderly Adults: The Dongfeng-Tongji Cohort StudyHongxia Li0Zhiqiang Cao1Jingxi Li2Lei King3Zhuangyu Zhang4Ying Zhao5Siyi Zhang6Yajing Song7Qian Zhang8Liangkai Chen9Yuhan Tang10Lingling Dai11Ping Yao12Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaExperimental Teaching Center of Preventive Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, ChinaMetabolic dysfunction-associated fatty liver disease (MAFLD) is the crucial pathogenesis for intra-hepatic and extra-hepatic diseases, especially in elderly adults. Lifestyle management may be a modifiable cost-effective measure for MAFLD prevention, but the evidence is limited. A total of 23,408 middle-aged and elderly individuals were included in a longitudinal study from 2008 to 2018. Combined lifestyle scores (range 0–6) were evaluated by BMI, smoking, drinking, diet, physical activity, and sleep. Logistic regression models were used to calculate ORs for the risks of MAFLD and specific subtypes. The mean age of participants was 61.7 years, and 44.5% were men. Compared with poor lifestyle (scores 0–2), ORs (95% CIs) of the ideal lifestyle (scores 5–6) were 0.62 (0.57–0.68) for MAFLD, 0.31 (0.28–0.34) for MAFLD with excess weight and obesity, 0.97 (0.75–1.26) for MAFLD with diabetes, and 0.56 (0.51–0.62) for MAFLD with metabolic dysregulation. Additionally, lifestyle improvement was associated with lower risks of MAFLD (OR, 0.76; 95% CI, 0.68–0.86), MAFLD with excess weight and obesity (OR, 0.72; 95% CI, 0.63–0.81), MAFLD with diabetes (OR, 0.74; 95% CI, 0.54–1.02) and MAFLD with metabolic dysregulation (OR, 0.49; 95% CI, 0.43–0.55), respectively. Our findings suggest that adherence to a combined healthy lifestyle was associated with lower risks of MAFLD, particularly in excess weight/obese individuals or those with metabolic dysregulation.https://www.mdpi.com/2072-6643/15/21/4588MAFLDcombined lifestyleBMIlifestyle improvement |
| spellingShingle | Hongxia Li Zhiqiang Cao Jingxi Li Lei King Zhuangyu Zhang Ying Zhao Siyi Zhang Yajing Song Qian Zhang Liangkai Chen Yuhan Tang Lingling Dai Ping Yao Associations of Combined Lifestyle Factors with MAFLD and the Specific Subtypes in Middle-Aged and Elderly Adults: The Dongfeng-Tongji Cohort Study Nutrients MAFLD combined lifestyle BMI lifestyle improvement |
| title | Associations of Combined Lifestyle Factors with MAFLD and the Specific Subtypes in Middle-Aged and Elderly Adults: The Dongfeng-Tongji Cohort Study |
| title_full | Associations of Combined Lifestyle Factors with MAFLD and the Specific Subtypes in Middle-Aged and Elderly Adults: The Dongfeng-Tongji Cohort Study |
| title_fullStr | Associations of Combined Lifestyle Factors with MAFLD and the Specific Subtypes in Middle-Aged and Elderly Adults: The Dongfeng-Tongji Cohort Study |
| title_full_unstemmed | Associations of Combined Lifestyle Factors with MAFLD and the Specific Subtypes in Middle-Aged and Elderly Adults: The Dongfeng-Tongji Cohort Study |
| title_short | Associations of Combined Lifestyle Factors with MAFLD and the Specific Subtypes in Middle-Aged and Elderly Adults: The Dongfeng-Tongji Cohort Study |
| title_sort | associations of combined lifestyle factors with mafld and the specific subtypes in middle aged and elderly adults the dongfeng tongji cohort study |
| topic | MAFLD combined lifestyle BMI lifestyle improvement |
| url | https://www.mdpi.com/2072-6643/15/21/4588 |
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