Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química Medicinal
Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry poin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2004-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300015 |
| _version_ | 1818963319899291648 |
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| author | Menegatti Ricardo Fraga Carlos Alberto Manssour Barreiro Eliezer J. Lima Vera Lucia Eifler Rates Stela Maris Kuze Dalla Costa Teresa |
| author_facet | Menegatti Ricardo Fraga Carlos Alberto Manssour Barreiro Eliezer J. Lima Vera Lucia Eifler Rates Stela Maris Kuze Dalla Costa Teresa |
| author_sort | Menegatti Ricardo |
| collection | DOAJ |
| description | Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relationships (SAR) and physico-chemical properties related with its molecular mechanism of action. |
| first_indexed | 2024-12-20T12:43:20Z |
| format | Article |
| id | doaj.art-2941ecf8089d4e1a8d04b87e3207dc76 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-20T12:43:20Z |
| publishDate | 2004-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-2941ecf8089d4e1a8d04b87e3207dc762022-12-21T19:40:23ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642004-01-01273447455Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química MedicinalMenegatti RicardoFraga Carlos Alberto ManssourBarreiro Eliezer J.Lima Vera Lucia EiflerRates Stela Maris KuzeDalla Costa TeresaSchizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relationships (SAR) and physico-chemical properties related with its molecular mechanism of action.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300015schizophreniaantipsychotic drugsdopamine receptor ligands |
| spellingShingle | Menegatti Ricardo Fraga Carlos Alberto Manssour Barreiro Eliezer J. Lima Vera Lucia Eifler Rates Stela Maris Kuze Dalla Costa Teresa Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química Medicinal Química Nova schizophrenia antipsychotic drugs dopamine receptor ligands |
| title | Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química Medicinal |
| title_full | Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química Medicinal |
| title_fullStr | Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química Medicinal |
| title_full_unstemmed | Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química Medicinal |
| title_short | Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química Medicinal |
| title_sort | esquizofrenia quarenta anos da hipotese dopaminergica sob a otica da quimica medicinal |
| topic | schizophrenia antipsychotic drugs dopamine receptor ligands |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300015 |
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