Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review
Human papillomavirus type 16 (HPV-16) is a well-known etiological factor for cervical and oropharyngeal cancers. The E2 protein, the product of an early-transcribed gene in HPV–16, is postulated to cause the death of cancerous cells via p53-dependent and p53-independent pathways. The main aim of the...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/20/12554 |
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| author | Dinah Farhanah Jamal Quratul Ain Rozaimee Nadila Haryani Osman Atikah Mohd Sukor Marjanu Hikmah Elias Nor Aripin Shamaan Srijit Das Nazefah Abdul Hamid |
| author_facet | Dinah Farhanah Jamal Quratul Ain Rozaimee Nadila Haryani Osman Atikah Mohd Sukor Marjanu Hikmah Elias Nor Aripin Shamaan Srijit Das Nazefah Abdul Hamid |
| author_sort | Dinah Farhanah Jamal |
| collection | DOAJ |
| description | Human papillomavirus type 16 (HPV-16) is a well-known etiological factor for cervical and oropharyngeal cancers. The E2 protein, the product of an early-transcribed gene in HPV–16, is postulated to cause the death of cancerous cells via p53-dependent and p53-independent pathways. The main aim of the present systematic review was to study the HPV 16-E2 protein as an apoptosis-inducer agent. A thorough search of MEDLINE/PubMed, Science Direct, Scopus, and EBSCOhost databases was conducted for relevant studies on HPV AND apoptosis OR cell death where HPV 16-E2 was involved. The search identified 967 publications. Eleven records dated from 1 January 1997 to 16 February 2022 were found to meet the inclusion criteria and were eligible for data extraction and inclusion. All studies concluded that HPV 16-E2 was able to induce cell death in transfected cells. E2 proteins from the high-risk HPV–16 were able to induce apoptosis through different apoptotic pathways depending on the location of the expressed gene. However, the mechanism was still unclear, and further studies are warranted. |
| first_indexed | 2024-03-09T20:04:35Z |
| format | Article |
| id | doaj.art-294568b6d9574f4ebc7ca8a84d3f8357 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:04:35Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-294568b6d9574f4ebc7ca8a84d3f83572023-11-24T00:33:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123201255410.3390/ijms232012554Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic ReviewDinah Farhanah Jamal0Quratul Ain Rozaimee1Nadila Haryani Osman2Atikah Mohd Sukor3Marjanu Hikmah Elias4Nor Aripin Shamaan5Srijit Das6Nazefah Abdul Hamid7Department of Basic Medical Science I, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai 71800, MalaysiaDepartment of Basic Medical Science I, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai 71800, MalaysiaDepartment of Basic Medical Science I, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai 71800, MalaysiaDepartment of Basic Medical Science I, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai 71800, MalaysiaDepartment of Basic Medical Science I, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai 71800, MalaysiaDepartment of Basic Medical Science I, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai 71800, MalaysiaDepartment of Human & Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, OmanDepartment of Basic Medical Science I, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai 71800, MalaysiaHuman papillomavirus type 16 (HPV-16) is a well-known etiological factor for cervical and oropharyngeal cancers. The E2 protein, the product of an early-transcribed gene in HPV–16, is postulated to cause the death of cancerous cells via p53-dependent and p53-independent pathways. The main aim of the present systematic review was to study the HPV 16-E2 protein as an apoptosis-inducer agent. A thorough search of MEDLINE/PubMed, Science Direct, Scopus, and EBSCOhost databases was conducted for relevant studies on HPV AND apoptosis OR cell death where HPV 16-E2 was involved. The search identified 967 publications. Eleven records dated from 1 January 1997 to 16 February 2022 were found to meet the inclusion criteria and were eligible for data extraction and inclusion. All studies concluded that HPV 16-E2 was able to induce cell death in transfected cells. E2 proteins from the high-risk HPV–16 were able to induce apoptosis through different apoptotic pathways depending on the location of the expressed gene. However, the mechanism was still unclear, and further studies are warranted.https://www.mdpi.com/1422-0067/23/20/12554apoptosiscell deathE2 proteinhuman papillomavirusHPV 16 |
| spellingShingle | Dinah Farhanah Jamal Quratul Ain Rozaimee Nadila Haryani Osman Atikah Mohd Sukor Marjanu Hikmah Elias Nor Aripin Shamaan Srijit Das Nazefah Abdul Hamid Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review International Journal of Molecular Sciences apoptosis cell death E2 protein human papillomavirus HPV 16 |
| title | Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review |
| title_full | Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review |
| title_fullStr | Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review |
| title_full_unstemmed | Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review |
| title_short | Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review |
| title_sort | human papillomavirus 16 e2 as an apoptosis inducing protein for cancer treatment a systematic review |
| topic | apoptosis cell death E2 protein human papillomavirus HPV 16 |
| url | https://www.mdpi.com/1422-0067/23/20/12554 |
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