Acute myeloblastic leukemia-associated Marfan syndrome and Davidoff-Dyke-Masson syndrome: a case report
We present herein a 23-year-old man with acute myeloblastic leukemia (AML) associated with Davidoff-Dyke-Masson syndrome (DDMS) and Marfan syndrome (MS). The diagnosis of DDMS was based on findings including left facial asymmetry, left hemiparesis, mental retardation, right cerebral hemiatrophy, dil...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2008-12-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | http://www.tjh.com.tr/jvi.asp?pdir=tjh&plng=eng&un=TJH-98608&look4= |
| _version_ | 1797918409003892736 |
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| author | Ahmet Faik Öner Imdat Dilek Ali Bay Cengiz Demir |
| author_facet | Ahmet Faik Öner Imdat Dilek Ali Bay Cengiz Demir |
| author_sort | Ahmet Faik Öner |
| collection | DOAJ |
| description | We present herein a 23-year-old man with acute myeloblastic leukemia (AML) associated with Davidoff-Dyke-Masson syndrome (DDMS) and Marfan syndrome (MS). The diagnosis of DDMS was based on findings including left facial asymmetry, left hemiparesis, mental retardation, right cerebral hemiatrophy, dilatation of the ipsilateral lateral ventricle and calvarial thickening. The diagnosis of MS was based on clinical findings including tall stature, myopia, retinitis pigmentosa, blue scleras, scoliosis, pectus excavatum, arachnodactyly and low ratio of upper/lower body segment. The patient developed hepatosplenomegaly, gingival hypertrophy and pancytopenia. Peripheral blood film and bone marrow examination showed that most of nucleated cells were blasts; immunophenotype of those cells showed CD11+, CD13+, CD14+, CD33+ and HLA-DR+. These findings confirmed the diagnosis of AML (FAB-M5). After induction chemotherapy, remission was obtained. To the best of our knowledge, our case is the third report of AML in MS syndrome, while AML associated with DDMS and MS has not been previously reported in the literature. |
| first_indexed | 2024-04-10T13:28:51Z |
| format | Article |
| id | doaj.art-29477e0685364ac39e899f212f35ed3d |
| institution | Directory Open Access Journal |
| issn | 1300-7777 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T13:28:51Z |
| publishDate | 2008-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-29477e0685364ac39e899f212f35ed3d2023-02-15T16:11:45ZengGalenos Publishing HouseTurkish Journal of Hematology1300-77771308-52632008-12-012504198200Acute myeloblastic leukemia-associated Marfan syndrome and Davidoff-Dyke-Masson syndrome: a case reportAhmet Faik ÖnerImdat DilekAli BayCengiz DemirWe present herein a 23-year-old man with acute myeloblastic leukemia (AML) associated with Davidoff-Dyke-Masson syndrome (DDMS) and Marfan syndrome (MS). The diagnosis of DDMS was based on findings including left facial asymmetry, left hemiparesis, mental retardation, right cerebral hemiatrophy, dilatation of the ipsilateral lateral ventricle and calvarial thickening. The diagnosis of MS was based on clinical findings including tall stature, myopia, retinitis pigmentosa, blue scleras, scoliosis, pectus excavatum, arachnodactyly and low ratio of upper/lower body segment. The patient developed hepatosplenomegaly, gingival hypertrophy and pancytopenia. Peripheral blood film and bone marrow examination showed that most of nucleated cells were blasts; immunophenotype of those cells showed CD11+, CD13+, CD14+, CD33+ and HLA-DR+. These findings confirmed the diagnosis of AML (FAB-M5). After induction chemotherapy, remission was obtained. To the best of our knowledge, our case is the third report of AML in MS syndrome, while AML associated with DDMS and MS has not been previously reported in the literature.http://www.tjh.com.tr/jvi.asp?pdir=tjh&plng=eng&un=TJH-98608&look4=Acute myeloblastic leukemiaDavidoff-Dyke-Masson syndromeMarfan syndrome |
| spellingShingle | Ahmet Faik Öner Imdat Dilek Ali Bay Cengiz Demir Acute myeloblastic leukemia-associated Marfan syndrome and Davidoff-Dyke-Masson syndrome: a case report Turkish Journal of Hematology Acute myeloblastic leukemia Davidoff-Dyke-Masson syndrome Marfan syndrome |
| title | Acute myeloblastic leukemia-associated Marfan syndrome and Davidoff-Dyke-Masson syndrome: a case report |
| title_full | Acute myeloblastic leukemia-associated Marfan syndrome and Davidoff-Dyke-Masson syndrome: a case report |
| title_fullStr | Acute myeloblastic leukemia-associated Marfan syndrome and Davidoff-Dyke-Masson syndrome: a case report |
| title_full_unstemmed | Acute myeloblastic leukemia-associated Marfan syndrome and Davidoff-Dyke-Masson syndrome: a case report |
| title_short | Acute myeloblastic leukemia-associated Marfan syndrome and Davidoff-Dyke-Masson syndrome: a case report |
| title_sort | acute myeloblastic leukemia associated marfan syndrome and davidoff dyke masson syndrome a case report |
| topic | Acute myeloblastic leukemia Davidoff-Dyke-Masson syndrome Marfan syndrome |
| url | http://www.tjh.com.tr/jvi.asp?pdir=tjh&plng=eng&un=TJH-98608&look4= |
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