From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home
Christian de Duve first coined the expression “autophagy” during his seminal work on the discovery of lysosomes, which led to him being awarded the Nobel Prize in Physiology or Medicine in 1974. The term was adopted to distinguish degradation of intracellular components from the uptake and degradati...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Biomedical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417016303274 |
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| author | Margaret M. Harnett Miguel A. Pineda Perle Latré de Laté Russell J. Eason Sébastien Besteiro William Harnett Gordon Langsley |
| author_facet | Margaret M. Harnett Miguel A. Pineda Perle Latré de Laté Russell J. Eason Sébastien Besteiro William Harnett Gordon Langsley |
| author_sort | Margaret M. Harnett |
| collection | DOAJ |
| description | Christian de Duve first coined the expression “autophagy” during his seminal work on the discovery of lysosomes, which led to him being awarded the Nobel Prize in Physiology or Medicine in 1974. The term was adopted to distinguish degradation of intracellular components from the uptake and degradation of extracellular substances that he called “heterophagy”. Studies until the 1990s were largely observational/morphological-based until in 1993 Yoshinori Oshumi described a genetic screen in yeast undergoing nitrogen deprivation that led to the isolation of autophagy-defective mutants now better known as ATG (AuTophaGy-related) genes. The screen identified mutants that fell into 15 complementation groups implying that at least 15 genes were involved in the regulation of autophagy in yeast undergoing nutrient deprivation, but today, 41 yeast ATG genes have been described and many (though not all) have orthologues in humans. Attempts to identify the genetic basis of autophagy led to an explosion in its research and it's not surprising that in 2016 Yoshinori Oshumi was awarded the Nobel Prize in Physiology or Medicine. Our aim here is not to exhaustively review the ever-expanding autophagy literature (>60 papers per week), but to celebrate Yoshinori Oshumi's Nobel Prize by highlighting just a few aspects that are not normally extensively covered. In an accompanying mini-review we address the role of autophagy in early-diverging eukaryote parasites that like yeast, lack lysosomes and so use a digestive vacuole to degrade autophagosome cargo and also discuss how parasitized host cells react to infection by subverting regulation of autophagy. |
| first_indexed | 2024-04-13T00:56:13Z |
| format | Article |
| id | doaj.art-2948d31d73ee497581f6e5cfd1be66d8 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-04-13T00:56:13Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-2948d31d73ee497581f6e5cfd1be66d82022-12-22T03:09:38ZengElsevierBiomedical Journal2319-41702017-02-0140192210.1016/j.bj.2016.12.004From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at homeMargaret M. Harnett0Miguel A. Pineda1Perle Latré de Laté2Russell J. Eason3Sébastien Besteiro4William Harnett5Gordon Langsley6Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UKInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UKInserm U1016, CNRS UMR8104, Cochin Institute, Paris, FranceInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UKDIMNP, UMR CNRS 5235, Montpellier University, Place Eugène Bataillon, Building 24, CC Montpellier, FranceStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UKInserm U1016, CNRS UMR8104, Cochin Institute, Paris, FranceChristian de Duve first coined the expression “autophagy” during his seminal work on the discovery of lysosomes, which led to him being awarded the Nobel Prize in Physiology or Medicine in 1974. The term was adopted to distinguish degradation of intracellular components from the uptake and degradation of extracellular substances that he called “heterophagy”. Studies until the 1990s were largely observational/morphological-based until in 1993 Yoshinori Oshumi described a genetic screen in yeast undergoing nitrogen deprivation that led to the isolation of autophagy-defective mutants now better known as ATG (AuTophaGy-related) genes. The screen identified mutants that fell into 15 complementation groups implying that at least 15 genes were involved in the regulation of autophagy in yeast undergoing nutrient deprivation, but today, 41 yeast ATG genes have been described and many (though not all) have orthologues in humans. Attempts to identify the genetic basis of autophagy led to an explosion in its research and it's not surprising that in 2016 Yoshinori Oshumi was awarded the Nobel Prize in Physiology or Medicine. Our aim here is not to exhaustively review the ever-expanding autophagy literature (>60 papers per week), but to celebrate Yoshinori Oshumi's Nobel Prize by highlighting just a few aspects that are not normally extensively covered. In an accompanying mini-review we address the role of autophagy in early-diverging eukaryote parasites that like yeast, lack lysosomes and so use a digestive vacuole to degrade autophagosome cargo and also discuss how parasitized host cells react to infection by subverting regulation of autophagy.http://www.sciencedirect.com/science/article/pii/S2319417016303274AutophagycAMP-PKAJNKInflammationInfection |
| spellingShingle | Margaret M. Harnett Miguel A. Pineda Perle Latré de Laté Russell J. Eason Sébastien Besteiro William Harnett Gordon Langsley From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home Biomedical Journal Autophagy cAMP-PKA JNK Inflammation Infection |
| title | From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home |
| title_full | From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home |
| title_fullStr | From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home |
| title_full_unstemmed | From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home |
| title_short | From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home |
| title_sort | from christian de duve to yoshinori ohsumi more to autophagy than just dining at home |
| topic | Autophagy cAMP-PKA JNK Inflammation Infection |
| url | http://www.sciencedirect.com/science/article/pii/S2319417016303274 |
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