Perinatal and early life factors and asthma control among preschoolers: a population-based retrospective cohort study
Background Preventing poor childhood asthma control is crucial for short-term and long-term respiratory health. This study evaluated associations between perinatal and early-life factors and early childhood asthma control.Methods This retrospective study used administrative health data from mothers...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-12-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/10/1/e001928.full |
| _version_ | 1797370846101110784 |
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| author | Maria B Ospina Francine M Ducharme Susan Crawford Jesus Serrano-Lomelin Anne Hicks Rhonda J Rosychuk Radha Chari Anita L Kozyrskyj Linn E Moore Jeffery Bakal |
| author_facet | Maria B Ospina Francine M Ducharme Susan Crawford Jesus Serrano-Lomelin Anne Hicks Rhonda J Rosychuk Radha Chari Anita L Kozyrskyj Linn E Moore Jeffery Bakal |
| author_sort | Maria B Ospina |
| collection | DOAJ |
| description | Background Preventing poor childhood asthma control is crucial for short-term and long-term respiratory health. This study evaluated associations between perinatal and early-life factors and early childhood asthma control.Methods This retrospective study used administrative health data from mothers and children born 2010–2012 with a diagnosis of asthma before age 5 years, in Alberta, Canada. The outcome was asthma control within 2 years after diagnosis. Associations between perinatal and early-life factors and risk of partly and uncontrolled asthma were evaluated by multinomial logistic regression.Results Of 7206 preschoolers with asthma, 52% had controlled, 37% partly controlled and 12% uncontrolled asthma 2 years after diagnosis. Compared with controlled asthma, prenatal antibiotics (adjusted risk ratio (aRR): 1.19; 95% CI 1.06 to 1.33) and smoking (aRR: 1.18; 95% CI 1.02 to 1.37), C-section delivery (aRR: 1.11; 95% CI 1.00 to 1.25), summer birth (aRR: 1.16; 95% CI 1.00 to 1.34) and early-life hospitalisation for respiratory illness (aRR: 2.24; 95% CI 1.81 to 2.76) increased the risk of partly controlled asthma. Gestational diabetes (aRR: 1.41; 95% CI 1.06 to 1.87), C-section delivery (aRR: 1.18; 95% CI 1.00 to 1.39), antibiotics (aRR: 1.32; 95% CI 1.08 to 1.61) and hospitalisation for early-life respiratory illness (aRR: 1.65; 95% CI 1.19 to 2.27) were associated with uncontrolled asthma.Conclusion Maternal perinatal and early-life factors including antibiotics in pregnancy and childhood, gestational diabetes, prenatal smoking, C-section and summertime birth, and hospitalisations for respiratory illness are associated with partly or uncontrolled childhood asthma. These results underline the significance of perinatal health and the lasting effects of early-life experiences on lung development and disease programming. |
| first_indexed | 2024-03-08T18:11:16Z |
| format | Article |
| id | doaj.art-2949d3c3d302436197baec56b314befc |
| institution | Directory Open Access Journal |
| issn | 2052-4439 |
| language | English |
| last_indexed | 2024-03-08T18:11:16Z |
| publishDate | 2023-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Respiratory Research |
| spelling | doaj.art-2949d3c3d302436197baec56b314befc2024-01-01T06:15:08ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392023-12-0110110.1136/bmjresp-2023-001928Perinatal and early life factors and asthma control among preschoolers: a population-based retrospective cohort studyMaria B Ospina0Francine M Ducharme1Susan Crawford2Jesus Serrano-Lomelin3Anne Hicks4Rhonda J Rosychuk5Radha Chari6Anita L Kozyrskyj7Linn E Moore8Jeffery Bakal9Department of Public Health Sciences, Queen`s University, Kingston, Ontario, CanadaDepartment of Pediatrics, University of Montreal, Montreal, Québec, CanadaAlberta Health Services, Edmonton, Alberta, CanadaDepartment of Public Health Sciences, Queen`s University, Kingston, Ontario, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, CanadaAlberta Health Services, Edmonton, Alberta, CanadaBackground Preventing poor childhood asthma control is crucial for short-term and long-term respiratory health. This study evaluated associations between perinatal and early-life factors and early childhood asthma control.Methods This retrospective study used administrative health data from mothers and children born 2010–2012 with a diagnosis of asthma before age 5 years, in Alberta, Canada. The outcome was asthma control within 2 years after diagnosis. Associations between perinatal and early-life factors and risk of partly and uncontrolled asthma were evaluated by multinomial logistic regression.Results Of 7206 preschoolers with asthma, 52% had controlled, 37% partly controlled and 12% uncontrolled asthma 2 years after diagnosis. Compared with controlled asthma, prenatal antibiotics (adjusted risk ratio (aRR): 1.19; 95% CI 1.06 to 1.33) and smoking (aRR: 1.18; 95% CI 1.02 to 1.37), C-section delivery (aRR: 1.11; 95% CI 1.00 to 1.25), summer birth (aRR: 1.16; 95% CI 1.00 to 1.34) and early-life hospitalisation for respiratory illness (aRR: 2.24; 95% CI 1.81 to 2.76) increased the risk of partly controlled asthma. Gestational diabetes (aRR: 1.41; 95% CI 1.06 to 1.87), C-section delivery (aRR: 1.18; 95% CI 1.00 to 1.39), antibiotics (aRR: 1.32; 95% CI 1.08 to 1.61) and hospitalisation for early-life respiratory illness (aRR: 1.65; 95% CI 1.19 to 2.27) were associated with uncontrolled asthma.Conclusion Maternal perinatal and early-life factors including antibiotics in pregnancy and childhood, gestational diabetes, prenatal smoking, C-section and summertime birth, and hospitalisations for respiratory illness are associated with partly or uncontrolled childhood asthma. These results underline the significance of perinatal health and the lasting effects of early-life experiences on lung development and disease programming.https://bmjopenrespres.bmj.com/content/10/1/e001928.full |
| spellingShingle | Maria B Ospina Francine M Ducharme Susan Crawford Jesus Serrano-Lomelin Anne Hicks Rhonda J Rosychuk Radha Chari Anita L Kozyrskyj Linn E Moore Jeffery Bakal Perinatal and early life factors and asthma control among preschoolers: a population-based retrospective cohort study BMJ Open Respiratory Research |
| title | Perinatal and early life factors and asthma control among preschoolers: a population-based retrospective cohort study |
| title_full | Perinatal and early life factors and asthma control among preschoolers: a population-based retrospective cohort study |
| title_fullStr | Perinatal and early life factors and asthma control among preschoolers: a population-based retrospective cohort study |
| title_full_unstemmed | Perinatal and early life factors and asthma control among preschoolers: a population-based retrospective cohort study |
| title_short | Perinatal and early life factors and asthma control among preschoolers: a population-based retrospective cohort study |
| title_sort | perinatal and early life factors and asthma control among preschoolers a population based retrospective cohort study |
| url | https://bmjopenrespres.bmj.com/content/10/1/e001928.full |
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