Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes

Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes

ABSTRACT Ehrlichia chaffeensis evades innate host defenses by reprogramming the mononuclear phagocyte through mechanisms that involve the exploitation of multiple evolutionarily conserved cellular signaling pathways, including Notch. This immune evasion strategy is directed in part by tandem repeat...

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Bibliographic Details
Main Authors: LaNisha L. Patterson, Thangam Sudha Velayutham, Caitlan D. Byerly, Duc Cuong Bui, Jignesh Patel, Veljko Veljkovic, Slobodan Paessler, Jere W. McBride
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:mBio
Subjects:
Ehrlichia
Notch signaling
effector
ligand
molecular mimicry
short linear motif
Online Access:https://journals.asm.org/doi/10.1128/mbio.00076-22

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