Diabetic Cardiomyopathy: Pathophysiology and Novel Therapies
Diabetes mellitus and heart failure have a bidirectional relationship and can affect one another. Ventricular dysfunction that occurs in the absence of coronary atherosclerosis and hypertension in patients with diabetes mellitus is termed diabetic cardiomyopathy. Lipotoxicity, increased oxidative st...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Department of Medicine, Warren Alpert Medical School at Brown University
2022-08-01
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| Series: | Brown Journal of Hospital Medicine |
| Online Access: | https://doi.org/10.56305/001c.37850 |
| _version_ | 1811252620605521920 |
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| author | Sidhi Laksono Grace T. Hosea Zahra Nurusshofa |
| author_facet | Sidhi Laksono Grace T. Hosea Zahra Nurusshofa |
| author_sort | Sidhi Laksono |
| collection | DOAJ |
| description | Diabetes mellitus and heart failure have a bidirectional relationship and can affect one another. Ventricular dysfunction that occurs in the absence of coronary atherosclerosis and hypertension in patients with diabetes mellitus is termed diabetic cardiomyopathy. Lipotoxicity, increased oxidative stress and mitochondrial dysfunction are a few of the mechanisms implicated in diabetic cardiomyopathy. Patients with diabetes mellitus undergo cardiac structural changes leading to heart failure. The novel glucose-lowering medication that is now preferred for diabetic patients with heart failure is the SGLT-2 (sodium-glucose cotransporter 2) inhibitor. Emerging targeted therapies are showing beneficial effects but require further evaluation. We review the literature describing the pathophysiology of diabetic cardiomyopathy, cardiac structural changes, along with the novel glucose-lowering therapies and targeted therapies for diabetic cardiomyopathy. |
| first_indexed | 2024-04-12T16:37:23Z |
| format | Article |
| id | doaj.art-294cdae48fb6489388491805d41ff9c7 |
| institution | Directory Open Access Journal |
| issn | 2831-5553 |
| language | English |
| last_indexed | 2024-04-12T16:37:23Z |
| publishDate | 2022-08-01 |
| publisher | Department of Medicine, Warren Alpert Medical School at Brown University |
| record_format | Article |
| series | Brown Journal of Hospital Medicine |
| spelling | doaj.art-294cdae48fb6489388491805d41ff9c72022-12-22T03:24:56ZengDepartment of Medicine, Warren Alpert Medical School at Brown UniversityBrown Journal of Hospital Medicine2831-55532022-08-0113Diabetic Cardiomyopathy: Pathophysiology and Novel TherapiesSidhi LaksonoGrace T. HoseaZahra NurusshofaDiabetes mellitus and heart failure have a bidirectional relationship and can affect one another. Ventricular dysfunction that occurs in the absence of coronary atherosclerosis and hypertension in patients with diabetes mellitus is termed diabetic cardiomyopathy. Lipotoxicity, increased oxidative stress and mitochondrial dysfunction are a few of the mechanisms implicated in diabetic cardiomyopathy. Patients with diabetes mellitus undergo cardiac structural changes leading to heart failure. The novel glucose-lowering medication that is now preferred for diabetic patients with heart failure is the SGLT-2 (sodium-glucose cotransporter 2) inhibitor. Emerging targeted therapies are showing beneficial effects but require further evaluation. We review the literature describing the pathophysiology of diabetic cardiomyopathy, cardiac structural changes, along with the novel glucose-lowering therapies and targeted therapies for diabetic cardiomyopathy.https://doi.org/10.56305/001c.37850 |
| spellingShingle | Sidhi Laksono Grace T. Hosea Zahra Nurusshofa Diabetic Cardiomyopathy: Pathophysiology and Novel Therapies Brown Journal of Hospital Medicine |
| title | Diabetic Cardiomyopathy: Pathophysiology and Novel Therapies |
| title_full | Diabetic Cardiomyopathy: Pathophysiology and Novel Therapies |
| title_fullStr | Diabetic Cardiomyopathy: Pathophysiology and Novel Therapies |
| title_full_unstemmed | Diabetic Cardiomyopathy: Pathophysiology and Novel Therapies |
| title_short | Diabetic Cardiomyopathy: Pathophysiology and Novel Therapies |
| title_sort | diabetic cardiomyopathy pathophysiology and novel therapies |
| url | https://doi.org/10.56305/001c.37850 |
| work_keys_str_mv | AT sidhilaksono diabeticcardiomyopathypathophysiologyandnoveltherapies AT gracethosea diabeticcardiomyopathypathophysiologyandnoveltherapies AT zahranurusshofa diabeticcardiomyopathypathophysiologyandnoveltherapies |