Liver Cirrhosis in a Patient with Sickle Cell Trait (Hb Sβ+ Thalassemia) without Other Known Causes of Hepatic Disease
Liver involvement in patients with sickle cell anemia/trait includes a wide range of alterations, from mild liver function test abnormalities to cirrhosis and acute liver failure. Approximately 15–30% of patients with sickle cell anemia present cirrhosis at autopsy. The pathogenesis of cirrhosis is...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2009-09-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/235235 |
| _version_ | 1828184435266158592 |
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| author | Luca Santi Giancarlo Montanari Sonia Berardi Corrado Patti Marta Frigerio Claudia Sama Paolo Caraceni Mauro Bernardi |
| author_facet | Luca Santi Giancarlo Montanari Sonia Berardi Corrado Patti Marta Frigerio Claudia Sama Paolo Caraceni Mauro Bernardi |
| author_sort | Luca Santi |
| collection | DOAJ |
| description | Liver involvement in patients with sickle cell anemia/trait includes a wide range of alterations, from mild liver function test abnormalities to cirrhosis and acute liver failure. Approximately 15–30% of patients with sickle cell anemia present cirrhosis at autopsy. The pathogenesis of cirrhosis is usually related to chronic hepatitis B or C infection or to iron overload resulting from the many transfusions received by these patients in their lifetime. Thus, cirrhosis has been described almost exclusively in patients with sickle cell anemia, while only mild liver abnormalities have been associated with the sickle cell trait. In the present case study, we describe a young Mediterranean man carrying a sickle cell trait (Hb Sβ+ thalassemia) who developed liver cirrhosis being negative for hepatitis C and B viruses or for other causes of cirrhosis and not receiving chronic blood transfusions. |
| first_indexed | 2024-04-12T06:48:52Z |
| format | Article |
| id | doaj.art-294d1a8458b94c8d885c3714147d7314 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-12T06:48:52Z |
| publishDate | 2009-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-294d1a8458b94c8d885c3714147d73142022-12-22T03:43:26ZengKarger PublishersCase Reports in Gastroenterology1662-06312009-09-013327527910.1159/000235235235235Liver Cirrhosis in a Patient with Sickle Cell Trait (Hb Sβ+ Thalassemia) without Other Known Causes of Hepatic DiseaseLuca SantiGiancarlo MontanariSonia BerardiCorrado PattiMarta FrigerioClaudia SamaPaolo CaraceniMauro BernardiLiver involvement in patients with sickle cell anemia/trait includes a wide range of alterations, from mild liver function test abnormalities to cirrhosis and acute liver failure. Approximately 15–30% of patients with sickle cell anemia present cirrhosis at autopsy. The pathogenesis of cirrhosis is usually related to chronic hepatitis B or C infection or to iron overload resulting from the many transfusions received by these patients in their lifetime. Thus, cirrhosis has been described almost exclusively in patients with sickle cell anemia, while only mild liver abnormalities have been associated with the sickle cell trait. In the present case study, we describe a young Mediterranean man carrying a sickle cell trait (Hb Sβ+ thalassemia) who developed liver cirrhosis being negative for hepatitis C and B viruses or for other causes of cirrhosis and not receiving chronic blood transfusions.http://www.karger.com/Article/FullText/235235Liver cirrhosisSickle cell diseaseSickle cell traitIron overload |
| spellingShingle | Luca Santi Giancarlo Montanari Sonia Berardi Corrado Patti Marta Frigerio Claudia Sama Paolo Caraceni Mauro Bernardi Liver Cirrhosis in a Patient with Sickle Cell Trait (Hb Sβ+ Thalassemia) without Other Known Causes of Hepatic Disease Case Reports in Gastroenterology Liver cirrhosis Sickle cell disease Sickle cell trait Iron overload |
| title | Liver Cirrhosis in a Patient with Sickle Cell Trait (Hb Sβ+ Thalassemia) without Other Known Causes of Hepatic Disease |
| title_full | Liver Cirrhosis in a Patient with Sickle Cell Trait (Hb Sβ+ Thalassemia) without Other Known Causes of Hepatic Disease |
| title_fullStr | Liver Cirrhosis in a Patient with Sickle Cell Trait (Hb Sβ+ Thalassemia) without Other Known Causes of Hepatic Disease |
| title_full_unstemmed | Liver Cirrhosis in a Patient with Sickle Cell Trait (Hb Sβ+ Thalassemia) without Other Known Causes of Hepatic Disease |
| title_short | Liver Cirrhosis in a Patient with Sickle Cell Trait (Hb Sβ+ Thalassemia) without Other Known Causes of Hepatic Disease |
| title_sort | liver cirrhosis in a patient with sickle cell trait hb sβ thalassemia without other known causes of hepatic disease |
| topic | Liver cirrhosis Sickle cell disease Sickle cell trait Iron overload |
| url | http://www.karger.com/Article/FullText/235235 |
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