A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion
Cerebral ischemia is one of the leading causes of death and disability worldwide. Although revascularization via reperfusion combined with advanced anticoagulant therapy is currently a gold standard treatment for patients, the reperfusion itself also results in a serious dysfunction termed cerebral...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1040182/full |
| _version_ | 1811216420345741312 |
|---|---|
| author | Yingying Tang Jiaqian Xie Xiaoping Chen Lihong Sun Lili Xu Xinzhong Chen |
| author_facet | Yingying Tang Jiaqian Xie Xiaoping Chen Lihong Sun Lili Xu Xinzhong Chen |
| author_sort | Yingying Tang |
| collection | DOAJ |
| description | Cerebral ischemia is one of the leading causes of death and disability worldwide. Although revascularization via reperfusion combined with advanced anticoagulant therapy is currently a gold standard treatment for patients, the reperfusion itself also results in a serious dysfunction termed cerebral ischemia-reperfusion (I/R) injury. Silent information regulator 1 (sirtuin 1, SIRT1), is a classic NAD+-dependent deacetylase, which has been proposed as an important mediator in the alleviation of cerebral ischemia through modulating multiple physiological processes, including apoptosis, inflammation, DNA repair, oxidative stress, and autophagy. Recent growing evidence suggests that SIRT1-mediated autophagy plays a key role in the pathophysiological process of cerebral I/R injury. SIRT1 could both activate and inhibit the autophagy process by mediating different autophagy pathways, such as the SIRT1-FOXOs pathway, SIRT1-AMPK pathway, and SIRT1-p53 pathway. However, the autophagic roles of SIRT1 in cerebral I/R injury have not been systematically summarized. Here, in this review, we will first introduce the molecular mechanisms and effects of SIRT1 in cerebral ischemia and I/R injury. Next, we will discuss the involvement of autophagy in the pathogenesis of cerebral I/R injury. Finally, we will summarize the latest advances in the interaction between SIRT1 and autophagy in cerebral I/R injury. A good understanding of these relationships would serve to consolidate a framework of mechanisms underlying SIRT1’s neuroprotective effects and provides evidence for the development of drugs targeting SIRT1. |
| first_indexed | 2024-04-12T06:38:54Z |
| format | Article |
| id | doaj.art-294d4c93888b4f2fa3a95d981dd95d62 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-12T06:38:54Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-294d4c93888b4f2fa3a95d981dd95d622022-12-22T03:43:46ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-11-011610.3389/fnins.2022.10401821040182A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusionYingying TangJiaqian XieXiaoping ChenLihong SunLili XuXinzhong ChenCerebral ischemia is one of the leading causes of death and disability worldwide. Although revascularization via reperfusion combined with advanced anticoagulant therapy is currently a gold standard treatment for patients, the reperfusion itself also results in a serious dysfunction termed cerebral ischemia-reperfusion (I/R) injury. Silent information regulator 1 (sirtuin 1, SIRT1), is a classic NAD+-dependent deacetylase, which has been proposed as an important mediator in the alleviation of cerebral ischemia through modulating multiple physiological processes, including apoptosis, inflammation, DNA repair, oxidative stress, and autophagy. Recent growing evidence suggests that SIRT1-mediated autophagy plays a key role in the pathophysiological process of cerebral I/R injury. SIRT1 could both activate and inhibit the autophagy process by mediating different autophagy pathways, such as the SIRT1-FOXOs pathway, SIRT1-AMPK pathway, and SIRT1-p53 pathway. However, the autophagic roles of SIRT1 in cerebral I/R injury have not been systematically summarized. Here, in this review, we will first introduce the molecular mechanisms and effects of SIRT1 in cerebral ischemia and I/R injury. Next, we will discuss the involvement of autophagy in the pathogenesis of cerebral I/R injury. Finally, we will summarize the latest advances in the interaction between SIRT1 and autophagy in cerebral I/R injury. A good understanding of these relationships would serve to consolidate a framework of mechanisms underlying SIRT1’s neuroprotective effects and provides evidence for the development of drugs targeting SIRT1.https://www.frontiersin.org/articles/10.3389/fnins.2022.1040182/fullcerebral ischemia-reperfusionSIRT1neuroprotectionautophagyautophagy signaling pathway |
| spellingShingle | Yingying Tang Jiaqian Xie Xiaoping Chen Lihong Sun Lili Xu Xinzhong Chen A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion Frontiers in Neuroscience cerebral ischemia-reperfusion SIRT1 neuroprotection autophagy autophagy signaling pathway |
| title | A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion |
| title_full | A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion |
| title_fullStr | A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion |
| title_full_unstemmed | A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion |
| title_short | A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion |
| title_sort | novel link between silent information regulator 1 and autophagy in cerebral ischemia reperfusion |
| topic | cerebral ischemia-reperfusion SIRT1 neuroprotection autophagy autophagy signaling pathway |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1040182/full |
| work_keys_str_mv | AT yingyingtang anovellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion AT jiaqianxie anovellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion AT xiaopingchen anovellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion AT lihongsun anovellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion AT lilixu anovellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion AT xinzhongchen anovellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion AT yingyingtang novellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion AT jiaqianxie novellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion AT xiaopingchen novellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion AT lihongsun novellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion AT lilixu novellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion AT xinzhongchen novellinkbetweensilentinformationregulator1andautophagyincerebralischemiareperfusion |