N6-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants
Liquid-like condensates are organized by multivalent intrinsically disordered proteins and RNA molecules. We here demonstrate that N6-methyladenosine (m6A)-modified RNA is widespread in establishing diverse plant cell condensates. Several m6A-reader proteins contain putative prion-like domains, and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Plant Signaling & Behavior |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592324.2022.2079308 |
| _version_ | 1797351949764395008 |
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| author | Hong Gil Lee Jiwoo Kim Pil Joon Seo |
| author_facet | Hong Gil Lee Jiwoo Kim Pil Joon Seo |
| author_sort | Hong Gil Lee |
| collection | DOAJ |
| description | Liquid-like condensates are organized by multivalent intrinsically disordered proteins and RNA molecules. We here demonstrate that N6-methyladenosine (m6A)-modified RNA is widespread in establishing diverse plant cell condensates. Several m6A-reader proteins contain putative prion-like domains, and the ect2/3/4 mutant exhibited reduced formation of key nuclear and cytoplasmic condensates in Arabidopsis. |
| first_indexed | 2024-03-08T13:08:04Z |
| format | Article |
| id | doaj.art-294d5894b56b405b9c246ea181520336 |
| institution | Directory Open Access Journal |
| issn | 1559-2316 1559-2324 |
| language | English |
| last_indexed | 2024-03-08T13:08:04Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Plant Signaling & Behavior |
| spelling | doaj.art-294d5894b56b405b9c246ea1815203362024-01-18T15:58:21ZengTaylor & Francis GroupPlant Signaling & Behavior1559-23161559-23242022-12-0117110.1080/15592324.2022.20793082079308N6-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plantsHong Gil Lee0Jiwoo Kim1Pil Joon Seo2Seoul National UniversitySeoul National UniversitySeoul National UniversityLiquid-like condensates are organized by multivalent intrinsically disordered proteins and RNA molecules. We here demonstrate that N6-methyladenosine (m6A)-modified RNA is widespread in establishing diverse plant cell condensates. Several m6A-reader proteins contain putative prion-like domains, and the ect2/3/4 mutant exhibited reduced formation of key nuclear and cytoplasmic condensates in Arabidopsis.http://dx.doi.org/10.1080/15592324.2022.2079308liquid-liquid phase separationm6a modificationm6a readerect |
| spellingShingle | Hong Gil Lee Jiwoo Kim Pil Joon Seo N6-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants Plant Signaling & Behavior liquid-liquid phase separation m6a modification m6a reader ect |
| title | N6-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants |
| title_full | N6-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants |
| title_fullStr | N6-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants |
| title_full_unstemmed | N6-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants |
| title_short | N6-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants |
| title_sort | n6 methyladenosine modified rna acts as a molecular glue that drives liquid liquid phase separation in plants |
| topic | liquid-liquid phase separation m6a modification m6a reader ect |
| url | http://dx.doi.org/10.1080/15592324.2022.2079308 |
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