DLPFC stimulation alters large-scale brain networks connectivity during a drug cue reactivity task: A tDCS-fMRI study
Transcranial direct current stimulation (tDCS) is a promising intervention for reducing craving/consumption in individuals with substance use disorders. However, its exact mechanism of action has not yet been well explored. We aimed to examine the network-based effects of tDCS while people with meth...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnsys.2022.956315/full |
| _version_ | 1817982402989916160 |
|---|---|
| author | Ghazaleh Soleimani Ghazaleh Soleimani Farzad Towhidkhah Mohammad Ali Oghabian Hamed Ekhtiari Hamed Ekhtiari |
| author_facet | Ghazaleh Soleimani Ghazaleh Soleimani Farzad Towhidkhah Mohammad Ali Oghabian Hamed Ekhtiari Hamed Ekhtiari |
| author_sort | Ghazaleh Soleimani |
| collection | DOAJ |
| description | Transcranial direct current stimulation (tDCS) is a promising intervention for reducing craving/consumption in individuals with substance use disorders. However, its exact mechanism of action has not yet been well explored. We aimed to examine the network-based effects of tDCS while people with methamphetamine use disorders (MUDs) were exposed to drug cues. In a randomized, double-blind sham-controlled trial with a crossover design, 15 participants with MUDs were recruited to receive 20 min of active/sham tDCS with an anode/cathode over F4/F3. MRI data, including structural and task-based functional MRI during a standard drug cue-reactivity task, were collected immediately before and after stimulation sessions. Craving scores were also recorded before and after MRI scans. Individualized head models were generated to determine brain regions with strong electric fields (EFs). Using atlas-based parcellation of head models, averaged EFs were extracted from the main nodes of three large-scale networks that showed abnormalities in MUDs; executive control (ECN), default mode (DMN), and ventral attention (VAN) networks. Main nodes with high EF intensity were used as seed regions for task-based functional connectivity (FC) [using generalized psychophysiological interaction (gPPI)] and activity [using a general linear model (GLM)] calculations. Subjective craving showed a significant reduction in immediate craving after active (–15.42 ± 5.42) compared to sham (–1 ± 2.63). In seed-to-whole brain results, the PFC node in ECN showed an enhanced PPI connectivity with precuneus and visual cortex; the cluster center in MNI (6, –84, –12); the PFC node in DMN showed a decreased PPI connectivity with contralateral parietal cortex;(–48, –60, 46). ROI-to-ROI results showed increased PPI connectivity within/between ECN-VAN while connectivity between ECN-DMN decreased. In line with connectivity, functional activity in the right PFC node in DMN decreased after tDCS while activity in PFC nodes of ECN/VAN increased. EF calculations in PFC nodes revealed that EF in DMN was outward, while the direction of EFs was inward in ECN/VAN. This study provides new insight into neural circuitry underlying MUDs that can be modulated by tDCS at the network level and specifically suggests that bilateral tDCS increases cortical excitability in ECN and VAN, while it has opposite effects on DMN that may be related to the direction of EFs. |
| first_indexed | 2024-04-13T23:20:25Z |
| format | Article |
| id | doaj.art-294dec219d32423da86ccedb324f9b7f |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-04-13T23:20:25Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-294dec219d32423da86ccedb324f9b7f2022-12-22T02:25:15ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372022-10-011610.3389/fnsys.2022.956315956315DLPFC stimulation alters large-scale brain networks connectivity during a drug cue reactivity task: A tDCS-fMRI studyGhazaleh Soleimani0Ghazaleh Soleimani1Farzad Towhidkhah2Mohammad Ali Oghabian3Hamed Ekhtiari4Hamed Ekhtiari5Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, IranIranian National Center for Addiction Studies, Tehran University of Medical Science, Tehran, IranDepartment of Biomedical Engineering, Amirkabir University of Technology, Tehran, IranNeuroimaging and Analysis Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, IranDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, United StatesLaureate Institute for Brain Research, Tulsa, OK, United StatesTranscranial direct current stimulation (tDCS) is a promising intervention for reducing craving/consumption in individuals with substance use disorders. However, its exact mechanism of action has not yet been well explored. We aimed to examine the network-based effects of tDCS while people with methamphetamine use disorders (MUDs) were exposed to drug cues. In a randomized, double-blind sham-controlled trial with a crossover design, 15 participants with MUDs were recruited to receive 20 min of active/sham tDCS with an anode/cathode over F4/F3. MRI data, including structural and task-based functional MRI during a standard drug cue-reactivity task, were collected immediately before and after stimulation sessions. Craving scores were also recorded before and after MRI scans. Individualized head models were generated to determine brain regions with strong electric fields (EFs). Using atlas-based parcellation of head models, averaged EFs were extracted from the main nodes of three large-scale networks that showed abnormalities in MUDs; executive control (ECN), default mode (DMN), and ventral attention (VAN) networks. Main nodes with high EF intensity were used as seed regions for task-based functional connectivity (FC) [using generalized psychophysiological interaction (gPPI)] and activity [using a general linear model (GLM)] calculations. Subjective craving showed a significant reduction in immediate craving after active (–15.42 ± 5.42) compared to sham (–1 ± 2.63). In seed-to-whole brain results, the PFC node in ECN showed an enhanced PPI connectivity with precuneus and visual cortex; the cluster center in MNI (6, –84, –12); the PFC node in DMN showed a decreased PPI connectivity with contralateral parietal cortex;(–48, –60, 46). ROI-to-ROI results showed increased PPI connectivity within/between ECN-VAN while connectivity between ECN-DMN decreased. In line with connectivity, functional activity in the right PFC node in DMN decreased after tDCS while activity in PFC nodes of ECN/VAN increased. EF calculations in PFC nodes revealed that EF in DMN was outward, while the direction of EFs was inward in ECN/VAN. This study provides new insight into neural circuitry underlying MUDs that can be modulated by tDCS at the network level and specifically suggests that bilateral tDCS increases cortical excitability in ECN and VAN, while it has opposite effects on DMN that may be related to the direction of EFs.https://www.frontiersin.org/articles/10.3389/fnsys.2022.956315/fulltranscranial direct current stimulation (tDCS)large-scale networkfrontoparietal network (ECN)default mode network (DMN)ventral attention network (VAN)methamphetamine use disorder (MUD) |
| spellingShingle | Ghazaleh Soleimani Ghazaleh Soleimani Farzad Towhidkhah Mohammad Ali Oghabian Hamed Ekhtiari Hamed Ekhtiari DLPFC stimulation alters large-scale brain networks connectivity during a drug cue reactivity task: A tDCS-fMRI study Frontiers in Systems Neuroscience transcranial direct current stimulation (tDCS) large-scale network frontoparietal network (ECN) default mode network (DMN) ventral attention network (VAN) methamphetamine use disorder (MUD) |
| title | DLPFC stimulation alters large-scale brain networks connectivity during a drug cue reactivity task: A tDCS-fMRI study |
| title_full | DLPFC stimulation alters large-scale brain networks connectivity during a drug cue reactivity task: A tDCS-fMRI study |
| title_fullStr | DLPFC stimulation alters large-scale brain networks connectivity during a drug cue reactivity task: A tDCS-fMRI study |
| title_full_unstemmed | DLPFC stimulation alters large-scale brain networks connectivity during a drug cue reactivity task: A tDCS-fMRI study |
| title_short | DLPFC stimulation alters large-scale brain networks connectivity during a drug cue reactivity task: A tDCS-fMRI study |
| title_sort | dlpfc stimulation alters large scale brain networks connectivity during a drug cue reactivity task a tdcs fmri study |
| topic | transcranial direct current stimulation (tDCS) large-scale network frontoparietal network (ECN) default mode network (DMN) ventral attention network (VAN) methamphetamine use disorder (MUD) |
| url | https://www.frontiersin.org/articles/10.3389/fnsys.2022.956315/full |
| work_keys_str_mv | AT ghazalehsoleimani dlpfcstimulationalterslargescalebrainnetworksconnectivityduringadrugcuereactivitytaskatdcsfmristudy AT ghazalehsoleimani dlpfcstimulationalterslargescalebrainnetworksconnectivityduringadrugcuereactivitytaskatdcsfmristudy AT farzadtowhidkhah dlpfcstimulationalterslargescalebrainnetworksconnectivityduringadrugcuereactivitytaskatdcsfmristudy AT mohammadalioghabian dlpfcstimulationalterslargescalebrainnetworksconnectivityduringadrugcuereactivitytaskatdcsfmristudy AT hamedekhtiari dlpfcstimulationalterslargescalebrainnetworksconnectivityduringadrugcuereactivitytaskatdcsfmristudy AT hamedekhtiari dlpfcstimulationalterslargescalebrainnetworksconnectivityduringadrugcuereactivitytaskatdcsfmristudy |