LDHA as a regulator of T cell fate and its mechanisms in disease
T cells are the main force of anti-infection and antitumor and are also involved in autoimmune diseases. During the development of these diseases, T cells need to rapidly produce large amounts of energy to satisfy their activation, proliferation, and differentiation. In this review, we introduced la...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222015530 |
| _version_ | 1811177265259610112 |
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| author | Maosha Dai Li Wang Juexi Yang Jiayi Chen Xiaoke Dou Rui Chen Yangyang Ge Yun Lin |
| author_facet | Maosha Dai Li Wang Juexi Yang Jiayi Chen Xiaoke Dou Rui Chen Yangyang Ge Yun Lin |
| author_sort | Maosha Dai |
| collection | DOAJ |
| description | T cells are the main force of anti-infection and antitumor and are also involved in autoimmune diseases. During the development of these diseases, T cells need to rapidly produce large amounts of energy to satisfy their activation, proliferation, and differentiation. In this review, we introduced lactate dehydrogenase A(LDHA), predominantly involved in glycolysis, which provides energy for T cells and plays a dual role in disease by mediating lactate production, non-classical enzyme activity, and oxidative stress. Mechanistically, the signaling molecule can interact with the LDHA promoter or regulate LDHA activity through post-translational modifications. These latest findings suggest that modulation of LDHA may have considerable therapeutic effects in diseases where T-cell activation is an important pathogenesis. |
| first_indexed | 2024-04-10T22:58:47Z |
| format | Article |
| id | doaj.art-294e834ad5c246a58284c8a7863f749f |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-10T22:58:47Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-294e834ad5c246a58284c8a7863f749f2023-01-14T04:26:03ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-02-01158114164LDHA as a regulator of T cell fate and its mechanisms in diseaseMaosha Dai0Li Wang1Juexi Yang2Jiayi Chen3Xiaoke Dou4Rui Chen5Yangyang Ge6Yun Lin7Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of ChinaDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of ChinaDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of ChinaDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of ChinaDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of ChinaDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of ChinaCorresponding authors.; Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of ChinaCorresponding authors.; Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of ChinaT cells are the main force of anti-infection and antitumor and are also involved in autoimmune diseases. During the development of these diseases, T cells need to rapidly produce large amounts of energy to satisfy their activation, proliferation, and differentiation. In this review, we introduced lactate dehydrogenase A(LDHA), predominantly involved in glycolysis, which provides energy for T cells and plays a dual role in disease by mediating lactate production, non-classical enzyme activity, and oxidative stress. Mechanistically, the signaling molecule can interact with the LDHA promoter or regulate LDHA activity through post-translational modifications. These latest findings suggest that modulation of LDHA may have considerable therapeutic effects in diseases where T-cell activation is an important pathogenesis.http://www.sciencedirect.com/science/article/pii/S0753332222015530Lactate dehydrogenase A (LDHA)ImmunometabolismImmune-related diseasesT lymphocytes |
| spellingShingle | Maosha Dai Li Wang Juexi Yang Jiayi Chen Xiaoke Dou Rui Chen Yangyang Ge Yun Lin LDHA as a regulator of T cell fate and its mechanisms in disease Biomedicine & Pharmacotherapy Lactate dehydrogenase A (LDHA) Immunometabolism Immune-related diseases T lymphocytes |
| title | LDHA as a regulator of T cell fate and its mechanisms in disease |
| title_full | LDHA as a regulator of T cell fate and its mechanisms in disease |
| title_fullStr | LDHA as a regulator of T cell fate and its mechanisms in disease |
| title_full_unstemmed | LDHA as a regulator of T cell fate and its mechanisms in disease |
| title_short | LDHA as a regulator of T cell fate and its mechanisms in disease |
| title_sort | ldha as a regulator of t cell fate and its mechanisms in disease |
| topic | Lactate dehydrogenase A (LDHA) Immunometabolism Immune-related diseases T lymphocytes |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222015530 |
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