A novel pulsed drug-delivery system: polyelectrolyte layer-by-layer coating of chitosan–alginate microgels
Guichen Zhou,1,2,* Ying Lu,1,* He Zhang,1,* Yan Chen,1 Yuan Yu,1 Jing Gao,1 Duxin Sun,3 Guoqing Zhang,2 Hao Zou,1 Yanqiang Zhong1 1Department of Pharmaceutical Science, Second Military Medical University, Shanghai, People's Republic of China; 2Department of Pharmacy, East Hospital of Hep...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2013-02-01
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| Series: | International Journal of Nanomedicine |
| Online Access: | http://www.dovepress.com/a-novel-pulsed-drug-delivery-system-polyelectrolyte-layer-by-layer-coa-a12325 |
| _version_ | 1819129911160340480 |
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| author | Zhou GC Lu Y Zhang H Chen Y Yu Y Gao J Sun DX Zhang GQ Zou H Zhong YQ |
| author_facet | Zhou GC Lu Y Zhang H Chen Y Yu Y Gao J Sun DX Zhang GQ Zou H Zhong YQ |
| author_sort | Zhou GC |
| collection | DOAJ |
| description | Guichen Zhou,1,2,* Ying Lu,1,* He Zhang,1,* Yan Chen,1 Yuan Yu,1 Jing Gao,1 Duxin Sun,3 Guoqing Zhang,2 Hao Zou,1 Yanqiang Zhong1 1Department of Pharmaceutical Science, Second Military Medical University, Shanghai, People's Republic of China; 2Department of Pharmacy, East Hospital of Hepatobiliary Surgery, Shanghai, People's Republic of China; 3Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA*These authors contributed equally to this workPurpose: The aim of this report was to introduce a novel “core-membrane” microgel drug-delivery device for spontaneously pulsed release without any external trigger.Methods: The microgel core was prepared with alginate and chitosan. The semipermeable membrane outside the microgel was made of polyelectrolytes including polycation poly(allylamine hydrochloride) and sodium polystyrene sulfonate. The drug release of this novel system was governed by the swelling pressure of the core and the rupture of the outer membrane.Results: The size of the core-membrane microgel drug-delivery device was 452.90 ± 2.71 µm. The surface charge depended on the layer-by-layer coating of polyelectrolytes, with zeta potential of 38.6 ± 1.4 mV. The confocal microscope exhibited the layer-by-layer outer membrane and inner core. The in vitro release profile showed that the content release remained low during the first 2.67 hours. After this lag time, the cumulative release increased to 80% in the next 0.95 hours, which suggested a pulsed drug release. The in vivo drug release in mice showed that the outer membrane was ruptured at approximately 3 to 4 hours, as drug was explosively released.Conclusion: These data suggest that the encapsulated substance in the core-membrane microgel delivery device can achieve a massive drug release after outer membrane rupture. This device was an effective system for pulsed drug delivery.Keywords: polyelectrolyte, chitosan–alginate, microgels, layer-by-layer, pulsed drug delivery |
| first_indexed | 2024-12-22T08:51:14Z |
| format | Article |
| id | doaj.art-294f79b175bc469da0bc600a0b7fff27 |
| institution | Directory Open Access Journal |
| issn | 1176-9114 1178-2013 |
| language | English |
| last_indexed | 2024-12-22T08:51:14Z |
| publishDate | 2013-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-294f79b175bc469da0bc600a0b7fff272022-12-21T18:31:58ZengDove Medical PressInternational Journal of Nanomedicine1176-91141178-20132013-02-012013default877887A novel pulsed drug-delivery system: polyelectrolyte layer-by-layer coating of chitosan–alginate microgelsZhou GCLu YZhang HChen YYu YGao JSun DXZhang GQZou HZhong YQGuichen Zhou,1,2,* Ying Lu,1,* He Zhang,1,* Yan Chen,1 Yuan Yu,1 Jing Gao,1 Duxin Sun,3 Guoqing Zhang,2 Hao Zou,1 Yanqiang Zhong1 1Department of Pharmaceutical Science, Second Military Medical University, Shanghai, People's Republic of China; 2Department of Pharmacy, East Hospital of Hepatobiliary Surgery, Shanghai, People's Republic of China; 3Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA*These authors contributed equally to this workPurpose: The aim of this report was to introduce a novel “core-membrane” microgel drug-delivery device for spontaneously pulsed release without any external trigger.Methods: The microgel core was prepared with alginate and chitosan. The semipermeable membrane outside the microgel was made of polyelectrolytes including polycation poly(allylamine hydrochloride) and sodium polystyrene sulfonate. The drug release of this novel system was governed by the swelling pressure of the core and the rupture of the outer membrane.Results: The size of the core-membrane microgel drug-delivery device was 452.90 ± 2.71 µm. The surface charge depended on the layer-by-layer coating of polyelectrolytes, with zeta potential of 38.6 ± 1.4 mV. The confocal microscope exhibited the layer-by-layer outer membrane and inner core. The in vitro release profile showed that the content release remained low during the first 2.67 hours. After this lag time, the cumulative release increased to 80% in the next 0.95 hours, which suggested a pulsed drug release. The in vivo drug release in mice showed that the outer membrane was ruptured at approximately 3 to 4 hours, as drug was explosively released.Conclusion: These data suggest that the encapsulated substance in the core-membrane microgel delivery device can achieve a massive drug release after outer membrane rupture. This device was an effective system for pulsed drug delivery.Keywords: polyelectrolyte, chitosan–alginate, microgels, layer-by-layer, pulsed drug deliveryhttp://www.dovepress.com/a-novel-pulsed-drug-delivery-system-polyelectrolyte-layer-by-layer-coa-a12325 |
| spellingShingle | Zhou GC Lu Y Zhang H Chen Y Yu Y Gao J Sun DX Zhang GQ Zou H Zhong YQ A novel pulsed drug-delivery system: polyelectrolyte layer-by-layer coating of chitosan–alginate microgels International Journal of Nanomedicine |
| title | A novel pulsed drug-delivery system: polyelectrolyte layer-by-layer coating of chitosan–alginate microgels |
| title_full | A novel pulsed drug-delivery system: polyelectrolyte layer-by-layer coating of chitosan–alginate microgels |
| title_fullStr | A novel pulsed drug-delivery system: polyelectrolyte layer-by-layer coating of chitosan–alginate microgels |
| title_full_unstemmed | A novel pulsed drug-delivery system: polyelectrolyte layer-by-layer coating of chitosan–alginate microgels |
| title_short | A novel pulsed drug-delivery system: polyelectrolyte layer-by-layer coating of chitosan–alginate microgels |
| title_sort | novel pulsed drug delivery system polyelectrolyte layer by layer coating of chitosan amp ndash alginate microgels |
| url | http://www.dovepress.com/a-novel-pulsed-drug-delivery-system-polyelectrolyte-layer-by-layer-coa-a12325 |
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