Subarachnoid extension and unfavorable outcomes in patients with supratentorial intracerebral hemorrhage
Abstract Objective Our study aimed to investigate the association between the subarachnoid extension of intracranial hemorrhage (SAHE) and clinical outcomes in patients with supratentorial intracerebral hemorrhage (ICH). Methods We analyzed the data from a prospective, multi-center, and registry-bas...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03087-9 |
| _version_ | 1811175795354238976 |
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| author | Jinjin Wang Dandan Wang Liheng Bian Anxin Wang Xiaoli Zhang Ruixuan Jiang Wenjuan Wang Yi Ju Jingjing Lu Xingquan Zhao |
| author_facet | Jinjin Wang Dandan Wang Liheng Bian Anxin Wang Xiaoli Zhang Ruixuan Jiang Wenjuan Wang Yi Ju Jingjing Lu Xingquan Zhao |
| author_sort | Jinjin Wang |
| collection | DOAJ |
| description | Abstract Objective Our study aimed to investigate the association between the subarachnoid extension of intracranial hemorrhage (SAHE) and clinical outcomes in patients with supratentorial intracerebral hemorrhage (ICH). Methods We analyzed the data from a prospective, multi-center, and registry-based database. Two experienced investigators independently assessed ICH imaging data. We compared baseline characteristics and follow-up outcomes. Multivariable logistic regression analysis was used to evaluate the association between SAHE and poor clinical outcomes. We also performed Kaplan–Meier curves and Cox proportional hazards regression analyses to analyze whether SAHE was relevant to a higher mortality rate. Results A total of 931 patients were included in this study (SAHE vs. no SAHE, 121 [13.0%] vs. 810 [87.0%]). Patients with SAHE had more severe neurological deficits, higher scores of the mRS, and more remarkable mortality rates at follow-up (all p values < 0.05). In multivariable-adjusted models, SAHE was independently associated with a higher risk of poor outcomes (adjusted OR [95%CI]: 2.030 [1.142–3.608] at 3 months; 2.348 [1.337–4.123] at 1 year). In addition, SAHE remained an independent association with an increased death rate at 1 year (adjusted HR [95%CI], 1.314[1.057–1.635]). In the subgroup analysis, the correlation between SAHE and prognosis exists in patients with lobar or deep ICH. Conclusions SAHE is independently associated with poor outcomes in patients with supratentorial ICH. It may provide a promising target for developing new predictive tools targeting ICH. |
| first_indexed | 2024-04-10T19:41:41Z |
| format | Article |
| id | doaj.art-294fa7c40ce44997b5976986820d244d |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-10T19:41:41Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-294fa7c40ce44997b5976986820d244d2023-01-29T12:15:33ZengBMCBMC Neurology1471-23772023-01-0123111010.1186/s12883-023-03087-9Subarachnoid extension and unfavorable outcomes in patients with supratentorial intracerebral hemorrhageJinjin Wang0Dandan Wang1Liheng Bian2Anxin Wang3Xiaoli Zhang4Ruixuan Jiang5Wenjuan Wang6Yi Ju7Jingjing Lu8Xingquan Zhao9Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Objective Our study aimed to investigate the association between the subarachnoid extension of intracranial hemorrhage (SAHE) and clinical outcomes in patients with supratentorial intracerebral hemorrhage (ICH). Methods We analyzed the data from a prospective, multi-center, and registry-based database. Two experienced investigators independently assessed ICH imaging data. We compared baseline characteristics and follow-up outcomes. Multivariable logistic regression analysis was used to evaluate the association between SAHE and poor clinical outcomes. We also performed Kaplan–Meier curves and Cox proportional hazards regression analyses to analyze whether SAHE was relevant to a higher mortality rate. Results A total of 931 patients were included in this study (SAHE vs. no SAHE, 121 [13.0%] vs. 810 [87.0%]). Patients with SAHE had more severe neurological deficits, higher scores of the mRS, and more remarkable mortality rates at follow-up (all p values < 0.05). In multivariable-adjusted models, SAHE was independently associated with a higher risk of poor outcomes (adjusted OR [95%CI]: 2.030 [1.142–3.608] at 3 months; 2.348 [1.337–4.123] at 1 year). In addition, SAHE remained an independent association with an increased death rate at 1 year (adjusted HR [95%CI], 1.314[1.057–1.635]). In the subgroup analysis, the correlation between SAHE and prognosis exists in patients with lobar or deep ICH. Conclusions SAHE is independently associated with poor outcomes in patients with supratentorial ICH. It may provide a promising target for developing new predictive tools targeting ICH.https://doi.org/10.1186/s12883-023-03087-9Subarachnoid extensionSupratentorial intracerebral hemorrhageClinical outcomesSurvival incidence |
| spellingShingle | Jinjin Wang Dandan Wang Liheng Bian Anxin Wang Xiaoli Zhang Ruixuan Jiang Wenjuan Wang Yi Ju Jingjing Lu Xingquan Zhao Subarachnoid extension and unfavorable outcomes in patients with supratentorial intracerebral hemorrhage BMC Neurology Subarachnoid extension Supratentorial intracerebral hemorrhage Clinical outcomes Survival incidence |
| title | Subarachnoid extension and unfavorable outcomes in patients with supratentorial intracerebral hemorrhage |
| title_full | Subarachnoid extension and unfavorable outcomes in patients with supratentorial intracerebral hemorrhage |
| title_fullStr | Subarachnoid extension and unfavorable outcomes in patients with supratentorial intracerebral hemorrhage |
| title_full_unstemmed | Subarachnoid extension and unfavorable outcomes in patients with supratentorial intracerebral hemorrhage |
| title_short | Subarachnoid extension and unfavorable outcomes in patients with supratentorial intracerebral hemorrhage |
| title_sort | subarachnoid extension and unfavorable outcomes in patients with supratentorial intracerebral hemorrhage |
| topic | Subarachnoid extension Supratentorial intracerebral hemorrhage Clinical outcomes Survival incidence |
| url | https://doi.org/10.1186/s12883-023-03087-9 |
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