Sporadic Parkinson’s Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland
Recent investigations demonstrated that genetic factors might play an important role in sporadic Parkinson’s disease (sPD). To clarify the specific loci susceptibility to sPD, we analyze the relationship between 30 candidate single nucleotide polymorphisms (SNPs) and sPD in the population of Han anc...
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2020.603793/full |
| _version_ | 1818666143713329152 |
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| author | Bo Wang Xin Liu Shengyuan Xu Zheng Liu Yu Zhu Xiong Zhang Renshi Xu Renshi Xu |
| author_facet | Bo Wang Xin Liu Shengyuan Xu Zheng Liu Yu Zhu Xiong Zhang Renshi Xu Renshi Xu |
| author_sort | Bo Wang |
| collection | DOAJ |
| description | Recent investigations demonstrated that genetic factors might play an important role in sporadic Parkinson’s disease (sPD). To clarify the specific loci susceptibility to sPD, we analyze the relationship between 30 candidate single nucleotide polymorphisms (SNPs) and sPD in the population of Han ancestry from Chinese mainland (HACM) by using genome-wide association study, sequenom massARRAY, DNA sequence, and biological information analysis. Results showed that the subjects carrying the T allele of rs863108 and rs28499371 exhibited a decreased risk for sPD. The subjects carrying the T allele of rs80315856 exhibited an increased risk for sPD. The A/T genotype of rs863108 and the C/T genotype of rs28499371 were a potential increased risk for sPD, and the G/T genotype of rs80315856 and T/T genotype of rs2270568 were a potential decreased risk for sPD. The minor allele frequency (MAF) of rs80315856 and rs2270568 was higher in sPD. The T allele of rs80315856 and rs2270568 might be a risk locus for sPD. Our data suggested that the alteration of these SNPs might play some roles through changing/affecting LINC01524/LOC105372666, DMRT2/SMARCA2, PLEKHN1, and FLJ23172/FNDC3B genes in the pathogenesis of sPD. |
| first_indexed | 2024-12-17T05:59:51Z |
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| id | doaj.art-2950f9b854a84732bc36e1b7fbfab1b7 |
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| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-17T05:59:51Z |
| publishDate | 2021-01-01 |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-2950f9b854a84732bc36e1b7fbfab1b72022-12-21T22:00:55ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-01-011210.3389/fnagi.2020.603793603793Sporadic Parkinson’s Disease Potential Risk Loci Identified in Han Ancestry of Chinese MainlandBo Wang0Xin Liu1Shengyuan Xu2Zheng Liu3Yu Zhu4Xiong Zhang5Renshi Xu6Renshi Xu7Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, Jiangxi Provincial People’s Hospital, The Affiliated People’s Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, Jiangxi Provincial People’s Hospital, The Affiliated People’s Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Neurology, Jiangxi Provincial People’s Hospital, The Affiliated People’s Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, Maoming People’s Hospital, Maoming, ChinaDepartment of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, Jiangxi Provincial People’s Hospital, The Affiliated People’s Hospital of Nanchang University, Nanchang, ChinaRecent investigations demonstrated that genetic factors might play an important role in sporadic Parkinson’s disease (sPD). To clarify the specific loci susceptibility to sPD, we analyze the relationship between 30 candidate single nucleotide polymorphisms (SNPs) and sPD in the population of Han ancestry from Chinese mainland (HACM) by using genome-wide association study, sequenom massARRAY, DNA sequence, and biological information analysis. Results showed that the subjects carrying the T allele of rs863108 and rs28499371 exhibited a decreased risk for sPD. The subjects carrying the T allele of rs80315856 exhibited an increased risk for sPD. The A/T genotype of rs863108 and the C/T genotype of rs28499371 were a potential increased risk for sPD, and the G/T genotype of rs80315856 and T/T genotype of rs2270568 were a potential decreased risk for sPD. The minor allele frequency (MAF) of rs80315856 and rs2270568 was higher in sPD. The T allele of rs80315856 and rs2270568 might be a risk locus for sPD. Our data suggested that the alteration of these SNPs might play some roles through changing/affecting LINC01524/LOC105372666, DMRT2/SMARCA2, PLEKHN1, and FLJ23172/FNDC3B genes in the pathogenesis of sPD.https://www.frontiersin.org/articles/10.3389/fnagi.2020.603793/fullgenetic polymorphismsingle nucleotide polymorphismspathogenesissporadic Parkinson’s diseaseChinese Han ancestry |
| spellingShingle | Bo Wang Xin Liu Shengyuan Xu Zheng Liu Yu Zhu Xiong Zhang Renshi Xu Renshi Xu Sporadic Parkinson’s Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland Frontiers in Aging Neuroscience genetic polymorphism single nucleotide polymorphisms pathogenesis sporadic Parkinson’s disease Chinese Han ancestry |
| title | Sporadic Parkinson’s Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland |
| title_full | Sporadic Parkinson’s Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland |
| title_fullStr | Sporadic Parkinson’s Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland |
| title_full_unstemmed | Sporadic Parkinson’s Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland |
| title_short | Sporadic Parkinson’s Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland |
| title_sort | sporadic parkinson s disease potential risk loci identified in han ancestry of chinese mainland |
| topic | genetic polymorphism single nucleotide polymorphisms pathogenesis sporadic Parkinson’s disease Chinese Han ancestry |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2020.603793/full |
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