Predictors of survival in non‐small cell lung cancer patients with pleural effusion undergoing thoracoscopy
Background Malignant pleural effusion (MPE) predicts advanced disease and poor prognosis, and is usually diagnosed by medical thoracoscopy. It remains unclear whether the various representations visualized on thoracoscopy are reliable prognostic factors. The aim of this study was to evaluate prognos...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-06-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.13086 |
| _version_ | 1818178195147456512 |
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| author | Li‐Xu Xie Xing‐Guang Wang Wen‐Jie You Xiao‐Bin Ma Yong‐Gang Wang Ting‐Ting Liu Shu‐Juan Jiang |
| author_facet | Li‐Xu Xie Xing‐Guang Wang Wen‐Jie You Xiao‐Bin Ma Yong‐Gang Wang Ting‐Ting Liu Shu‐Juan Jiang |
| author_sort | Li‐Xu Xie |
| collection | DOAJ |
| description | Background Malignant pleural effusion (MPE) predicts advanced disease and poor prognosis, and is usually diagnosed by medical thoracoscopy. It remains unclear whether the various representations visualized on thoracoscopy are reliable prognostic factors. The aim of this study was to evaluate prognostic factors for survival in patients who underwent thoracoscopy for MPE. Methods The medical records of consecutive patients with MPE who underwent medical thoracoscopy from 2007 to 2015 at a tertiary hospital were reviewed and theKaplan‐Meier method and Cox regression analysis used to determine prognostic factors. Results A total of 125 patients with non‐small cell lung cancer (NSCLC) were confirmed on tissue biopsy as having pleural metastasis. In NSCLC, factors adversely affecting overall survival (OS) in univariate analysis included extent of pleural carcinomatosis (EPC) score (P = 0.031), grade of adhesions (P = 0.037), costoparietal pleural lesions (P = 0.035) and bloody MPE (P = 0.023); Cox multivariate analysis revealed that EPC score (P = 0.007) and grade of adhesions (P = 0.019) were independent predictors of OS. Conclusions Under traditional chemotherapy, higher EPC score and higher grades of adhesions predicted poor prognosis in advanced NSCLC patients with pleural metastasis. Taking into account these factors may allow doctors to make more accurate predictions and provide individual therapy when treating patients with MPE. |
| first_indexed | 2024-12-11T20:44:07Z |
| format | Article |
| id | doaj.art-2952f5460b6b4baeaacf919d540035c1 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-12-11T20:44:07Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-2952f5460b6b4baeaacf919d540035c12022-12-22T00:51:25ZengWileyThoracic Cancer1759-77061759-77142019-06-011061412141810.1111/1759-7714.13086Predictors of survival in non‐small cell lung cancer patients with pleural effusion undergoing thoracoscopyLi‐Xu Xie0Xing‐Guang Wang1Wen‐Jie You2Xiao‐Bin Ma3Yong‐Gang Wang4Ting‐Ting Liu5Shu‐Juan Jiang6Department of Respiratory and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong University Jinan ChinaDepartment of Respiratory and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong University Jinan ChinaDepartment of Respiratory and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong University Jinan ChinaDepartment of Respiratory and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong University Jinan ChinaDepartment of Respiratory and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong University Jinan ChinaDepartment of Respiratory and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong University Jinan ChinaDepartment of Respiratory and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong University Jinan ChinaBackground Malignant pleural effusion (MPE) predicts advanced disease and poor prognosis, and is usually diagnosed by medical thoracoscopy. It remains unclear whether the various representations visualized on thoracoscopy are reliable prognostic factors. The aim of this study was to evaluate prognostic factors for survival in patients who underwent thoracoscopy for MPE. Methods The medical records of consecutive patients with MPE who underwent medical thoracoscopy from 2007 to 2015 at a tertiary hospital were reviewed and theKaplan‐Meier method and Cox regression analysis used to determine prognostic factors. Results A total of 125 patients with non‐small cell lung cancer (NSCLC) were confirmed on tissue biopsy as having pleural metastasis. In NSCLC, factors adversely affecting overall survival (OS) in univariate analysis included extent of pleural carcinomatosis (EPC) score (P = 0.031), grade of adhesions (P = 0.037), costoparietal pleural lesions (P = 0.035) and bloody MPE (P = 0.023); Cox multivariate analysis revealed that EPC score (P = 0.007) and grade of adhesions (P = 0.019) were independent predictors of OS. Conclusions Under traditional chemotherapy, higher EPC score and higher grades of adhesions predicted poor prognosis in advanced NSCLC patients with pleural metastasis. Taking into account these factors may allow doctors to make more accurate predictions and provide individual therapy when treating patients with MPE.https://doi.org/10.1111/1759-7714.13086Malignant pleural effusionnon‐small cell lung cancerprognosisthoracoscopy |
| spellingShingle | Li‐Xu Xie Xing‐Guang Wang Wen‐Jie You Xiao‐Bin Ma Yong‐Gang Wang Ting‐Ting Liu Shu‐Juan Jiang Predictors of survival in non‐small cell lung cancer patients with pleural effusion undergoing thoracoscopy Thoracic Cancer Malignant pleural effusion non‐small cell lung cancer prognosis thoracoscopy |
| title | Predictors of survival in non‐small cell lung cancer patients with pleural effusion undergoing thoracoscopy |
| title_full | Predictors of survival in non‐small cell lung cancer patients with pleural effusion undergoing thoracoscopy |
| title_fullStr | Predictors of survival in non‐small cell lung cancer patients with pleural effusion undergoing thoracoscopy |
| title_full_unstemmed | Predictors of survival in non‐small cell lung cancer patients with pleural effusion undergoing thoracoscopy |
| title_short | Predictors of survival in non‐small cell lung cancer patients with pleural effusion undergoing thoracoscopy |
| title_sort | predictors of survival in non small cell lung cancer patients with pleural effusion undergoing thoracoscopy |
| topic | Malignant pleural effusion non‐small cell lung cancer prognosis thoracoscopy |
| url | https://doi.org/10.1111/1759-7714.13086 |
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