Clinical observation on healing of tarsal plate defect after reconstruction with xenogeneic acellular dermal matrix
Abstract Objective To evaluate the safety, function, and cosmetic outcome of eyelid reconstruction using a xenogeneic acellular dermal matrix as a tarsal plate replacement in the repair of 50 to 100% eyelid defects following excision of large malignant tumours. Methods A retrospective, non-comparati...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-022-02540-6 |
| _version_ | 1828778160564469760 |
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| author | Qin Huang Yangbin Fang Yaohua Wang Hongfei Liao |
| author_facet | Qin Huang Yangbin Fang Yaohua Wang Hongfei Liao |
| author_sort | Qin Huang |
| collection | DOAJ |
| description | Abstract Objective To evaluate the safety, function, and cosmetic outcome of eyelid reconstruction using a xenogeneic acellular dermal matrix as a tarsal plate replacement in the repair of 50 to 100% eyelid defects following excision of large malignant tumours. Methods A retrospective, non-comparative, interventional study of 21 eyes was performed over 26 months. Fourteen patients were female and seven were male. In all cases, a xenogeneic acellular dermal matrix was used for total or subtotal replacement of the tarsal plate. The central vertical height of the palpebral fissure was measured immediately after eyelid margin incision and at 1 and 6 months postoperatively. Results In patients who underwent surgery, the mean palpebral fissure height (PFH) was not significantly different between immediately and 1 month after incision (8.10 ± 0.562 mm vs 8.17 ± 0.577 mm, respectively; P > 0.05). After 6 months, PFH was 8.26 ± 0.605 mm, which was significantly different from that immediately after incision (P < 0.05). After 6 months of follow-up, all patients had a good aesthetic appearance after eyelid reconstruction, with no obvious graft dissolution or rejection, normal eyelid activity, and normal opening, closing, and lifting function. None of the 21 patients experienced tumour recurrence during postoperative follow-up. Conclusion The xenogeneic acellular dermal matrix was a successful tarsal plate replacement. This material is readily available, and a second surgical site is avoided. The xenogeneic acellular dermal matrix is considered a promising alternative material for tarsal replacement in future generations. |
| first_indexed | 2024-12-11T16:35:47Z |
| format | Article |
| id | doaj.art-29534a821a414c2abd618075c0912990 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-11T16:35:47Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-29534a821a414c2abd618075c09129902022-12-22T00:58:27ZengBMCBMC Ophthalmology1471-24152022-07-012211710.1186/s12886-022-02540-6Clinical observation on healing of tarsal plate defect after reconstruction with xenogeneic acellular dermal matrixQin Huang0Yangbin Fang1Yaohua Wang2Hongfei Liao3Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for OphthalmologyAffiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for OphthalmologyAffiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for OphthalmologyAffiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for OphthalmologyAbstract Objective To evaluate the safety, function, and cosmetic outcome of eyelid reconstruction using a xenogeneic acellular dermal matrix as a tarsal plate replacement in the repair of 50 to 100% eyelid defects following excision of large malignant tumours. Methods A retrospective, non-comparative, interventional study of 21 eyes was performed over 26 months. Fourteen patients were female and seven were male. In all cases, a xenogeneic acellular dermal matrix was used for total or subtotal replacement of the tarsal plate. The central vertical height of the palpebral fissure was measured immediately after eyelid margin incision and at 1 and 6 months postoperatively. Results In patients who underwent surgery, the mean palpebral fissure height (PFH) was not significantly different between immediately and 1 month after incision (8.10 ± 0.562 mm vs 8.17 ± 0.577 mm, respectively; P > 0.05). After 6 months, PFH was 8.26 ± 0.605 mm, which was significantly different from that immediately after incision (P < 0.05). After 6 months of follow-up, all patients had a good aesthetic appearance after eyelid reconstruction, with no obvious graft dissolution or rejection, normal eyelid activity, and normal opening, closing, and lifting function. None of the 21 patients experienced tumour recurrence during postoperative follow-up. Conclusion The xenogeneic acellular dermal matrix was a successful tarsal plate replacement. This material is readily available, and a second surgical site is avoided. The xenogeneic acellular dermal matrix is considered a promising alternative material for tarsal replacement in future generations.https://doi.org/10.1186/s12886-022-02540-6Xenogeneic acellular dermal matrixMalignancyReconstruction |
| spellingShingle | Qin Huang Yangbin Fang Yaohua Wang Hongfei Liao Clinical observation on healing of tarsal plate defect after reconstruction with xenogeneic acellular dermal matrix BMC Ophthalmology Xenogeneic acellular dermal matrix Malignancy Reconstruction |
| title | Clinical observation on healing of tarsal plate defect after reconstruction with xenogeneic acellular dermal matrix |
| title_full | Clinical observation on healing of tarsal plate defect after reconstruction with xenogeneic acellular dermal matrix |
| title_fullStr | Clinical observation on healing of tarsal plate defect after reconstruction with xenogeneic acellular dermal matrix |
| title_full_unstemmed | Clinical observation on healing of tarsal plate defect after reconstruction with xenogeneic acellular dermal matrix |
| title_short | Clinical observation on healing of tarsal plate defect after reconstruction with xenogeneic acellular dermal matrix |
| title_sort | clinical observation on healing of tarsal plate defect after reconstruction with xenogeneic acellular dermal matrix |
| topic | Xenogeneic acellular dermal matrix Malignancy Reconstruction |
| url | https://doi.org/10.1186/s12886-022-02540-6 |
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