Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats
Objective : To investigate the effect of the methanolic extract of Erythrina variegata (Linn.) var Orientalis (Fabaceae) seeds (MEEV) in reducing the cholesterol levels and as well as antioxidant in experimentally induced hyperlipidemic rats. Materials and Methods : Doses of 200 and 400 mg/kg of the...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2010;volume=2;issue=4;spage=350;epage=355;aulast=Balamurugan |
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| author | G Balamurugan A Shantha |
| author_facet | G Balamurugan A Shantha |
| author_sort | G Balamurugan |
| collection | DOAJ |
| description | Objective : To investigate the effect of the methanolic extract of Erythrina variegata (Linn.) var Orientalis (Fabaceae) seeds (MEEV) in reducing the cholesterol levels and as well as antioxidant in experimentally induced hyperlipidemic rats. Materials and Methods : Doses of 200 and 400 mg/kg of the extract were evaluated for its effect on lipid profile, HMG-CoA reductase, and on antioxidant enzymes in high-fat diet (HFD) induced hyperlipidemia. Results and Conclusion : The elevated levels of total cholesterol, triglycerides, low-density lipoprotein, and very low density lipoprotein due to HFD was reduced by concurrent treatment with MEEV (200 and 400 mg/kg) significantly (P<0.001). A significant reduction (P<0.001) in high-density lipoprotein was noticed in HFD fed groups; however, a nonsignificant increment was produced by the administration of MEEV (200 and 400 mg/kg). The HMG-CoA reductase activity was increased in HFD fed animals significantly (P<0.001) and was reduced by MEEV 400 mg/kg significantly (P<0.001). There was a noticed increase in the body weight and mesenteric fat pad weight in HFD fed group (P<0.001), which was reduced by the administration of MEEV (200 and 400 mg/kg). The antioxidant enzymes such as superoxide dismutase and catalase were reduced significantly in the HFD fed group, whose levels were increased significantly (P<0.001) by the administration of MEEV (200 and 400 mg/kg). Lipid peroxidation was increased in HFD fed animals, which was reduced significantly (P<0.001) by the treatment with MEEV (200 and 400 mg/kg). |
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| format | Article |
| id | doaj.art-2955514678a14c13ab474291c158d485 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 0976-4879 |
| language | English |
| last_indexed | 2024-12-17T10:32:15Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-2955514678a14c13ab474291c158d4852022-12-21T21:52:29ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74060976-48792010-01-0124350355Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar ratsG BalamuruganA ShanthaObjective : To investigate the effect of the methanolic extract of Erythrina variegata (Linn.) var Orientalis (Fabaceae) seeds (MEEV) in reducing the cholesterol levels and as well as antioxidant in experimentally induced hyperlipidemic rats. Materials and Methods : Doses of 200 and 400 mg/kg of the extract were evaluated for its effect on lipid profile, HMG-CoA reductase, and on antioxidant enzymes in high-fat diet (HFD) induced hyperlipidemia. Results and Conclusion : The elevated levels of total cholesterol, triglycerides, low-density lipoprotein, and very low density lipoprotein due to HFD was reduced by concurrent treatment with MEEV (200 and 400 mg/kg) significantly (P<0.001). A significant reduction (P<0.001) in high-density lipoprotein was noticed in HFD fed groups; however, a nonsignificant increment was produced by the administration of MEEV (200 and 400 mg/kg). The HMG-CoA reductase activity was increased in HFD fed animals significantly (P<0.001) and was reduced by MEEV 400 mg/kg significantly (P<0.001). There was a noticed increase in the body weight and mesenteric fat pad weight in HFD fed group (P<0.001), which was reduced by the administration of MEEV (200 and 400 mg/kg). The antioxidant enzymes such as superoxide dismutase and catalase were reduced significantly in the HFD fed group, whose levels were increased significantly (P<0.001) by the administration of MEEV (200 and 400 mg/kg). Lipid peroxidation was increased in HFD fed animals, which was reduced significantly (P<0.001) by the treatment with MEEV (200 and 400 mg/kg).http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2010;volume=2;issue=4;spage=350;epage=355;aulast=BalamuruganAntioxidant enzymesErythrina variegatahigh fat dietHMG-CoA reductaselipid profileβ-sitosterol |
| spellingShingle | G Balamurugan A Shantha Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats Journal of Pharmacy and Bioallied Sciences Antioxidant enzymes Erythrina variegata high fat diet HMG-CoA reductase lipid profile β-sitosterol |
| title | Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
| title_full | Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
| title_fullStr | Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
| title_full_unstemmed | Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
| title_short | Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
| title_sort | effect of erythrina variegata seed extract on hyperlipidemia elicited by high fat diet in wistar rats |
| topic | Antioxidant enzymes Erythrina variegata high fat diet HMG-CoA reductase lipid profile β-sitosterol |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2010;volume=2;issue=4;spage=350;epage=355;aulast=Balamurugan |
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