Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization
Abstract Background Intrahepatic cholestasis of pregnancy (ICP) is an idiopathic disease of pregnancy. Little is known about how it specifically affects pregnancies resulting from in vitro fertilization (IVF). Our aim is to evaluate the impact of IVF on the perinatal outcomes of ICP. Methods A retro...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-024-06248-x |
| _version_ | 1797355420464971776 |
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| author | Ying Zhu Le Xu Rajluxmee Beejadhursing Fei Li |
| author_facet | Ying Zhu Le Xu Rajluxmee Beejadhursing Fei Li |
| author_sort | Ying Zhu |
| collection | DOAJ |
| description | Abstract Background Intrahepatic cholestasis of pregnancy (ICP) is an idiopathic disease of pregnancy. Little is known about how it specifically affects pregnancies resulting from in vitro fertilization (IVF). Our aim is to evaluate the impact of IVF on the perinatal outcomes of ICP. Methods A retrospective study of 242 patients with intrahepatic cholestasis of pregnancy, comprising 36 conceived through IVF and 206 spontaneous conceptions (SC), enrolled between 2019 and 2021 was carried out. Data were analyzed from the medical archives of the Huazhong University of Science and Technology, Tongji Hospital. Results Numerical values of transaminases (ALT, alanine aminotransferase; AST, aspartate aminotransferase) and serum total bile acid (TBA) are significantly lower in the IVF group than that in the spontaneous conceived group (p < 0.05). The incidence of gestational diabetes mellitus (GDM) was higher in the IVF group than in SC group (30.6% vs. 16%, p = 0.037). The cesarean section (CS) rates are higher in the IVF group (97.2% vs. 85.4%, p = 0.023). On the other hand, the prevalence of premature rupture of membranes (PROM) was higher in the SC group (10.7%) while none was reported in the IVF-ICP group. Other maternal comorbidities and neonatal outcomes were similar between the two groups. Conclusion ICP patients who underwent IVF are more likely to suffer from GDM. Therefore, monitoring and management of blood glucose should be strengthened during pregnancy. Fortunately, IVF does not seem to worsen the progression or outlook of ICP, so sticking to standard management practices is recommended. |
| first_indexed | 2024-03-08T14:10:48Z |
| format | Article |
| id | doaj.art-295b2fe40c414b7e8e7659a3023babff |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-03-08T14:10:48Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-295b2fe40c414b7e8e7659a3023babff2024-01-14T12:42:01ZengBMCBMC Pregnancy and Childbirth1471-23932024-01-012411510.1186/s12884-024-06248-xMaternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilizationYing Zhu0Le Xu1Rajluxmee Beejadhursing2Fei Li3Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Intrahepatic cholestasis of pregnancy (ICP) is an idiopathic disease of pregnancy. Little is known about how it specifically affects pregnancies resulting from in vitro fertilization (IVF). Our aim is to evaluate the impact of IVF on the perinatal outcomes of ICP. Methods A retrospective study of 242 patients with intrahepatic cholestasis of pregnancy, comprising 36 conceived through IVF and 206 spontaneous conceptions (SC), enrolled between 2019 and 2021 was carried out. Data were analyzed from the medical archives of the Huazhong University of Science and Technology, Tongji Hospital. Results Numerical values of transaminases (ALT, alanine aminotransferase; AST, aspartate aminotransferase) and serum total bile acid (TBA) are significantly lower in the IVF group than that in the spontaneous conceived group (p < 0.05). The incidence of gestational diabetes mellitus (GDM) was higher in the IVF group than in SC group (30.6% vs. 16%, p = 0.037). The cesarean section (CS) rates are higher in the IVF group (97.2% vs. 85.4%, p = 0.023). On the other hand, the prevalence of premature rupture of membranes (PROM) was higher in the SC group (10.7%) while none was reported in the IVF-ICP group. Other maternal comorbidities and neonatal outcomes were similar between the two groups. Conclusion ICP patients who underwent IVF are more likely to suffer from GDM. Therefore, monitoring and management of blood glucose should be strengthened during pregnancy. Fortunately, IVF does not seem to worsen the progression or outlook of ICP, so sticking to standard management practices is recommended.https://doi.org/10.1186/s12884-024-06248-xIntrahepatic cholestasis of pregnancyIn vitro fertilizationMaternal complicationsNeonatal outcomes |
| spellingShingle | Ying Zhu Le Xu Rajluxmee Beejadhursing Fei Li Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization BMC Pregnancy and Childbirth Intrahepatic cholestasis of pregnancy In vitro fertilization Maternal complications Neonatal outcomes |
| title | Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization |
| title_full | Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization |
| title_fullStr | Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization |
| title_full_unstemmed | Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization |
| title_short | Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization |
| title_sort | maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization |
| topic | Intrahepatic cholestasis of pregnancy In vitro fertilization Maternal complications Neonatal outcomes |
| url | https://doi.org/10.1186/s12884-024-06248-x |
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