Primary Laryngeal Aspergillosis in an Immunocompetent Host
Introduction Aspergillosis of Larynx is very rare and may present with symptoms suspicious of malignancy. Prevention of dissemination warrants early diagnosis. It is found mainly in Immunocompromised patients and is usually necrotizing, invasive with disseminated systemic infection, associated with...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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The Association of Otolaryngologists of India, West Bengal
2018-08-01
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| Series: | Bengal Journal of Otolaryngology and Head Neck Surgery |
| Subjects: | |
| Online Access: | https://bjohns.in/journal/index.php/bjohns/article/view/315 |
| _version_ | 1797282880287670272 |
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| author | Kaustuv Das Biswas Ankit Choudhary Swapan Kumar Ghosh Subhradev Biswas |
| author_facet | Kaustuv Das Biswas Ankit Choudhary Swapan Kumar Ghosh Subhradev Biswas |
| author_sort | Kaustuv Das Biswas |
| collection | DOAJ |
| description | Introduction
Aspergillosis of Larynx is very rare and may present with symptoms suspicious of malignancy. Prevention of dissemination warrants early diagnosis. It is found mainly in Immunocompromised patients and is usually necrotizing, invasive with disseminated systemic infection, associated with poor prognosis. In Immunocompetent patients it is extremely rare and may present as colonization associated with excellent prognosis.
Case Report
A 43 year old male patient presented with hoarseness of voice for about 3 months with whitish irregular lesion that involved the anterior 1/3 of both the vocal cords. A cheesy material was found covering indurated lesion of both the vocal cords, intraoperatively. Stripping of mucosa over vocal cords was done and cheesy material collected and sent for HPE which revealed Aspergillus hyphae overlying Mild dysplastic changes. Following diagnosis the patient was followed up with oral dosages of Itraconazole.
Discussion
The primary Aspergillosis of larynx is extremely rare. Involvement is always secondary to immunocompromised states like AIDS, malignancy, Diabetes, etc. This was a rare case in Immunocompetent patient.
Management constitute removal of the vocal cord lesions during biopsy. Amphotericin B is first-line agent for this infection, however aerosolised and liposomal amphotericin B offer effective dosing with less toxicity. Newer antifungal Itraconazole may produce more reliable results. |
| first_indexed | 2024-03-07T17:20:53Z |
| format | Article |
| id | doaj.art-295cf46e47d0468f88d1ecae2f444842 |
| institution | Directory Open Access Journal |
| issn | 2395-2407 2395-2407 |
| language | English |
| last_indexed | 2024-03-07T17:20:53Z |
| publishDate | 2018-08-01 |
| publisher | The Association of Otolaryngologists of India, West Bengal |
| record_format | Article |
| series | Bengal Journal of Otolaryngology and Head Neck Surgery |
| spelling | doaj.art-295cf46e47d0468f88d1ecae2f4448422024-03-02T20:11:50ZengThe Association of Otolaryngologists of India, West BengalBengal Journal of Otolaryngology and Head Neck Surgery2395-24072395-24072018-08-01262131133161Primary Laryngeal Aspergillosis in an Immunocompetent HostKaustuv Das Biswas0Ankit Choudhary1Swapan Kumar Ghosh2Subhradev Biswas3SSKM hospital and IPGMERSSKM hospital and IPGMERSSKM hospital and IPGMERSSKM hospital and IPGMERIntroduction Aspergillosis of Larynx is very rare and may present with symptoms suspicious of malignancy. Prevention of dissemination warrants early diagnosis. It is found mainly in Immunocompromised patients and is usually necrotizing, invasive with disseminated systemic infection, associated with poor prognosis. In Immunocompetent patients it is extremely rare and may present as colonization associated with excellent prognosis. Case Report A 43 year old male patient presented with hoarseness of voice for about 3 months with whitish irregular lesion that involved the anterior 1/3 of both the vocal cords. A cheesy material was found covering indurated lesion of both the vocal cords, intraoperatively. Stripping of mucosa over vocal cords was done and cheesy material collected and sent for HPE which revealed Aspergillus hyphae overlying Mild dysplastic changes. Following diagnosis the patient was followed up with oral dosages of Itraconazole. Discussion The primary Aspergillosis of larynx is extremely rare. Involvement is always secondary to immunocompromised states like AIDS, malignancy, Diabetes, etc. This was a rare case in Immunocompetent patient. Management constitute removal of the vocal cord lesions during biopsy. Amphotericin B is first-line agent for this infection, however aerosolised and liposomal amphotericin B offer effective dosing with less toxicity. Newer antifungal Itraconazole may produce more reliable results.https://bjohns.in/journal/index.php/bjohns/article/view/315LarynxAspergillosisItraconazole |
| spellingShingle | Kaustuv Das Biswas Ankit Choudhary Swapan Kumar Ghosh Subhradev Biswas Primary Laryngeal Aspergillosis in an Immunocompetent Host Bengal Journal of Otolaryngology and Head Neck Surgery Larynx Aspergillosis Itraconazole |
| title | Primary Laryngeal Aspergillosis in an Immunocompetent Host |
| title_full | Primary Laryngeal Aspergillosis in an Immunocompetent Host |
| title_fullStr | Primary Laryngeal Aspergillosis in an Immunocompetent Host |
| title_full_unstemmed | Primary Laryngeal Aspergillosis in an Immunocompetent Host |
| title_short | Primary Laryngeal Aspergillosis in an Immunocompetent Host |
| title_sort | primary laryngeal aspergillosis in an immunocompetent host |
| topic | Larynx Aspergillosis Itraconazole |
| url | https://bjohns.in/journal/index.php/bjohns/article/view/315 |
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