Ocular Drug, Gene and Cellular Delivery Systems and Advanced Therapy Medicinal Products
Due to recent advances in science and technology, when the products used in therapy are examined, ophthalmology has a priority in terms of research and development, preclinical and clinical studies of innovative drugs, medical devices and drug-medical device combination products. Liposomes, micelles...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2018-06-01
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| Series: | Türk Oftalmoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.oftalmoloji.org/archives/archive-detail/article-preview/ocular-drug-gene-and-cellular-delivery-systems-and/19075 |
| _version_ | 1797924100253941760 |
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| author | Türkan Eldem Bora Eldem |
| author_facet | Türkan Eldem Bora Eldem |
| author_sort | Türkan Eldem |
| collection | DOAJ |
| description | Due to recent advances in science and technology, when the products used in therapy are examined, ophthalmology has a priority in terms of research and development, preclinical and clinical studies of innovative drugs, medical devices and drug-medical device combination products. Liposomes, micelles, nanoemulsions, nanoparticles with colloidal structures and intraocular implants as sustained-release drug delivery systems have been developed to overcome the barriers to ocular applications, increase absorption, decrease metabolism and elimination and increase the residence time in ocular tissues and compartments. Studies are also ongoing in the area of advanced therapies using gene or cell-based systems which are high-risk products due to their complex structures. In this review, ocular drug, gene and cellular delivery systems and related products and developments in advanced therapy medicinal products are presented in respect to the definition of drug (medicinal product) and current changes in legislation. |
| first_indexed | 2024-04-10T14:56:17Z |
| format | Article |
| id | doaj.art-2960efa4277f4c46ba5aac9785b563ec |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T14:56:17Z |
| publishDate | 2018-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-2960efa4277f4c46ba5aac9785b563ec2023-02-15T16:07:19ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612018-06-0148313214110.4274/tjo.32458Ocular Drug, Gene and Cellular Delivery Systems and Advanced Therapy Medicinal ProductsTürkan Eldem0Bora Eldem1Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical Biotechnology, Ankara, Turkey & Hacettepe University Institute of Health Sciences, Department of Stem Cell Sciences, Ankara, TurkeyHacettepe University Faculty of Pharmacy, Department of Pharmaceutical Biotechnology, Ankara, Turkey & Hacettepe University Institute of Health Sciences, Department of Stem Cell Sciences, Ankara, TurkeyDue to recent advances in science and technology, when the products used in therapy are examined, ophthalmology has a priority in terms of research and development, preclinical and clinical studies of innovative drugs, medical devices and drug-medical device combination products. Liposomes, micelles, nanoemulsions, nanoparticles with colloidal structures and intraocular implants as sustained-release drug delivery systems have been developed to overcome the barriers to ocular applications, increase absorption, decrease metabolism and elimination and increase the residence time in ocular tissues and compartments. Studies are also ongoing in the area of advanced therapies using gene or cell-based systems which are high-risk products due to their complex structures. In this review, ocular drug, gene and cellular delivery systems and related products and developments in advanced therapy medicinal products are presented in respect to the definition of drug (medicinal product) and current changes in legislation.http://www.oftalmoloji.org/archives/archive-detail/article-preview/ocular-drug-gene-and-cellular-delivery-systems-and/19075Ocular delivery systemsocular gene and cellular delivery systemscolloidal drug and gene delivery systemsadvanced therapy medicinal productsnational and international legislation |
| spellingShingle | Türkan Eldem Bora Eldem Ocular Drug, Gene and Cellular Delivery Systems and Advanced Therapy Medicinal Products Türk Oftalmoloji Dergisi Ocular delivery systems ocular gene and cellular delivery systems colloidal drug and gene delivery systems advanced therapy medicinal products national and international legislation |
| title | Ocular Drug, Gene and Cellular Delivery Systems and Advanced Therapy Medicinal Products |
| title_full | Ocular Drug, Gene and Cellular Delivery Systems and Advanced Therapy Medicinal Products |
| title_fullStr | Ocular Drug, Gene and Cellular Delivery Systems and Advanced Therapy Medicinal Products |
| title_full_unstemmed | Ocular Drug, Gene and Cellular Delivery Systems and Advanced Therapy Medicinal Products |
| title_short | Ocular Drug, Gene and Cellular Delivery Systems and Advanced Therapy Medicinal Products |
| title_sort | ocular drug gene and cellular delivery systems and advanced therapy medicinal products |
| topic | Ocular delivery systems ocular gene and cellular delivery systems colloidal drug and gene delivery systems advanced therapy medicinal products national and international legislation |
| url | http://www.oftalmoloji.org/archives/archive-detail/article-preview/ocular-drug-gene-and-cellular-delivery-systems-and/19075 |
| work_keys_str_mv | AT turkaneldem oculardruggeneandcellulardeliverysystemsandadvancedtherapymedicinalproducts AT boraeldem oculardruggeneandcellulardeliverysystemsandadvancedtherapymedicinalproducts |