In Vivo Toxicity, Redox-Modulating Capacity and Intestinal Permeability of Novel Aroylhydrazone Derivatives as Anti-Tuberculosis Agents

In Vivo Toxicity, Redox-Modulating Capacity and Intestinal Permeability of Novel Aroylhydrazone Derivatives as Anti-Tuberculosis Agents

The emergence and spread of <i>Mycobacterium tuberculosis</i> strains resistant to many or all anti-tuberculosis (TB) drugs require the development of new compounds both efficient and with minimal side effects. Structure-activity-toxicity relationships of such novel, structurally diverse...

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Bibliographic Details
Main Authors: Violeta Valcheva, Rumyana Simeonova, Milka Mileva, Stanislav Philipov, Reneta Petrova, Simeon Dimitrov, Almira Georgieva, Elina Tsvetanova, Yoana Teneva, Violina T. Angelova
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
aroylhydrazone derivatives
acute and sub-acute toxicity
redox-modulating capacity
GIT permeability
pathomorphological evaluation
Online Access:https://www.mdpi.com/1999-4923/15/1/79

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