Case Report: Neonatal Varicella Acquired From Maternal Zoster
The incidence of neonatal varicella has decreased dramatically since the introduction of the varicella vaccination. Although the varicella zoster virus is often associated with a mild infection, it may cause severe morbidity and mortality, particularly in the neonatal period and immunocompromised ho...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2021.649775/full |
| _version_ | 1818725991561822208 |
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| author | Jeffrey W. Lai Jeffrey W. Lai Timothy Ford Sarah Cherian Anita J. Campbell Anita J. Campbell Christopher C. Blyth Christopher C. Blyth Christopher C. Blyth |
| author_facet | Jeffrey W. Lai Jeffrey W. Lai Timothy Ford Sarah Cherian Anita J. Campbell Anita J. Campbell Christopher C. Blyth Christopher C. Blyth Christopher C. Blyth |
| author_sort | Jeffrey W. Lai |
| collection | DOAJ |
| description | The incidence of neonatal varicella has decreased dramatically since the introduction of the varicella vaccination. Although the varicella zoster virus is often associated with a mild infection, it may cause severe morbidity and mortality, particularly in the neonatal period and immunocompromised hosts. We report a case of neonatal varicella acquired from maternal zoster in a mother on biological immunosuppressive therapy. Following the diagnosis, the baby improved on antiviral therapy without any neurological sequelae. This case highlights the limited published data on neonatal varicella following herpes zoster reactivation to inform practice. This includes the role of varicella zoster immunoglobulin in neonates exposed to maternal zoster, the degree of trans-placental immunity and optimum antiviral dosing and duration. |
| first_indexed | 2024-12-17T21:51:06Z |
| format | Article |
| id | doaj.art-2964498910ee417a969af8eb09389800 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-17T21:51:06Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-2964498910ee417a969af8eb093898002022-12-21T21:31:18ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-03-01910.3389/fped.2021.649775649775Case Report: Neonatal Varicella Acquired From Maternal ZosterJeffrey W. Lai0Jeffrey W. Lai1Timothy Ford2Sarah Cherian3Anita J. Campbell4Anita J. Campbell5Christopher C. Blyth6Christopher C. Blyth7Christopher C. Blyth8School of Medicine, The University of Western Australia, Crawley, WA, AustraliaDepartment of Infectious Diseases, Perth Children's Hospital, Nedlands, WA, AustraliaDepartment of Infectious Diseases, Perth Children's Hospital, Nedlands, WA, AustraliaDepartment of Infectious Diseases, Perth Children's Hospital, Nedlands, WA, AustraliaDepartment of Infectious Diseases, Perth Children's Hospital, Nedlands, WA, AustraliaWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA, AustraliaSchool of Medicine, The University of Western Australia, Crawley, WA, AustraliaDepartment of Infectious Diseases, Perth Children's Hospital, Nedlands, WA, AustraliaWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA, AustraliaThe incidence of neonatal varicella has decreased dramatically since the introduction of the varicella vaccination. Although the varicella zoster virus is often associated with a mild infection, it may cause severe morbidity and mortality, particularly in the neonatal period and immunocompromised hosts. We report a case of neonatal varicella acquired from maternal zoster in a mother on biological immunosuppressive therapy. Following the diagnosis, the baby improved on antiviral therapy without any neurological sequelae. This case highlights the limited published data on neonatal varicella following herpes zoster reactivation to inform practice. This includes the role of varicella zoster immunoglobulin in neonates exposed to maternal zoster, the degree of trans-placental immunity and optimum antiviral dosing and duration.https://www.frontiersin.org/articles/10.3389/fped.2021.649775/fullneonatal varicellamaternal zostermaternal immunosuppressiontrans-placental immunityvaricella zoster immune globulin |
| spellingShingle | Jeffrey W. Lai Jeffrey W. Lai Timothy Ford Sarah Cherian Anita J. Campbell Anita J. Campbell Christopher C. Blyth Christopher C. Blyth Christopher C. Blyth Case Report: Neonatal Varicella Acquired From Maternal Zoster Frontiers in Pediatrics neonatal varicella maternal zoster maternal immunosuppression trans-placental immunity varicella zoster immune globulin |
| title | Case Report: Neonatal Varicella Acquired From Maternal Zoster |
| title_full | Case Report: Neonatal Varicella Acquired From Maternal Zoster |
| title_fullStr | Case Report: Neonatal Varicella Acquired From Maternal Zoster |
| title_full_unstemmed | Case Report: Neonatal Varicella Acquired From Maternal Zoster |
| title_short | Case Report: Neonatal Varicella Acquired From Maternal Zoster |
| title_sort | case report neonatal varicella acquired from maternal zoster |
| topic | neonatal varicella maternal zoster maternal immunosuppression trans-placental immunity varicella zoster immune globulin |
| url | https://www.frontiersin.org/articles/10.3389/fped.2021.649775/full |
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