Regulation of the iron-deficiency response by IMA/FEP peptide
Iron (Fe) is an essential micronutrient for plant growth and development, participating in many significant biological processes including photosynthesis, respiration, and nitrogen fixation. Although abundant in the earth’s crust, most Fe is oxidized and difficult for plants to absorb under aerobic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2023.1107405/full |
| _version_ | 1797839857543806976 |
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| author | Ryo Tabata |
| author_facet | Ryo Tabata |
| author_sort | Ryo Tabata |
| collection | DOAJ |
| description | Iron (Fe) is an essential micronutrient for plant growth and development, participating in many significant biological processes including photosynthesis, respiration, and nitrogen fixation. Although abundant in the earth’s crust, most Fe is oxidized and difficult for plants to absorb under aerobic and alkaline pH conditions. Plants, therefore, have evolved complex means to optimize their Fe-acquisition efficiency. In the past two decades, regulatory networks of transcription factors and ubiquitin ligases have proven to be essential for plant Fe uptake and translocation. Recent studies in Arabidopsis thaliana (Arabidopsis) suggest that in addition to the transcriptional network, IRON MAN/FE-UPTAKE-INDUCING PEPTIDE (IMA/FEP) peptide interacts with a ubiquitin ligase, BRUTUS (BTS)/BTS-LIKE (BTSL). Under Fe-deficient conditions, IMA/FEP peptides compete with IVc subgroup bHLH transcription factors (TFs) to interact with BTS/BTSL. The resulting complex inhibits the degradation of these TFs by BTS/BTSL, which is important for maintaining the Fe-deficiency response in roots. Furthermore, IMA/FEP peptides control systemic Fe signaling. By organ-to-organ communication in Arabidopsis, Fe deficiency in one part of a root drives the upregulation of a high-affinity Fe-uptake system in other root regions surrounded by sufficient levels of Fe. IMA/FEP peptides regulate this compensatory response through Fe-deficiency-triggered organ-to-organ communication. This mini-review summarizes recent advances in understanding how IMA/FEP peptides function in the intracellular signaling of the Fe-deficiency response and systemic Fe signaling to regulate Fe acquisition. |
| first_indexed | 2024-04-09T16:04:59Z |
| format | Article |
| id | doaj.art-2965eef3a32a4e10aefc7bb3b195ac9a |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-04-09T16:04:59Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-2965eef3a32a4e10aefc7bb3b195ac9a2023-04-25T06:42:38ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2023-04-011410.3389/fpls.2023.11074051107405Regulation of the iron-deficiency response by IMA/FEP peptideRyo TabataIron (Fe) is an essential micronutrient for plant growth and development, participating in many significant biological processes including photosynthesis, respiration, and nitrogen fixation. Although abundant in the earth’s crust, most Fe is oxidized and difficult for plants to absorb under aerobic and alkaline pH conditions. Plants, therefore, have evolved complex means to optimize their Fe-acquisition efficiency. In the past two decades, regulatory networks of transcription factors and ubiquitin ligases have proven to be essential for plant Fe uptake and translocation. Recent studies in Arabidopsis thaliana (Arabidopsis) suggest that in addition to the transcriptional network, IRON MAN/FE-UPTAKE-INDUCING PEPTIDE (IMA/FEP) peptide interacts with a ubiquitin ligase, BRUTUS (BTS)/BTS-LIKE (BTSL). Under Fe-deficient conditions, IMA/FEP peptides compete with IVc subgroup bHLH transcription factors (TFs) to interact with BTS/BTSL. The resulting complex inhibits the degradation of these TFs by BTS/BTSL, which is important for maintaining the Fe-deficiency response in roots. Furthermore, IMA/FEP peptides control systemic Fe signaling. By organ-to-organ communication in Arabidopsis, Fe deficiency in one part of a root drives the upregulation of a high-affinity Fe-uptake system in other root regions surrounded by sufficient levels of Fe. IMA/FEP peptides regulate this compensatory response through Fe-deficiency-triggered organ-to-organ communication. This mini-review summarizes recent advances in understanding how IMA/FEP peptides function in the intracellular signaling of the Fe-deficiency response and systemic Fe signaling to regulate Fe acquisition.https://www.frontiersin.org/articles/10.3389/fpls.2023.1107405/fulliron deficiency responseIRON MAN/FE-UPTAKE-INDUCING PEPTIDEFe uptakeorgan-to-organ communicationsystemic Fe signaling |
| spellingShingle | Ryo Tabata Regulation of the iron-deficiency response by IMA/FEP peptide Frontiers in Plant Science iron deficiency response IRON MAN/FE-UPTAKE-INDUCING PEPTIDE Fe uptake organ-to-organ communication systemic Fe signaling |
| title | Regulation of the iron-deficiency response by IMA/FEP peptide |
| title_full | Regulation of the iron-deficiency response by IMA/FEP peptide |
| title_fullStr | Regulation of the iron-deficiency response by IMA/FEP peptide |
| title_full_unstemmed | Regulation of the iron-deficiency response by IMA/FEP peptide |
| title_short | Regulation of the iron-deficiency response by IMA/FEP peptide |
| title_sort | regulation of the iron deficiency response by ima fep peptide |
| topic | iron deficiency response IRON MAN/FE-UPTAKE-INDUCING PEPTIDE Fe uptake organ-to-organ communication systemic Fe signaling |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2023.1107405/full |
| work_keys_str_mv | AT ryotabata regulationoftheirondeficiencyresponsebyimafeppeptide |