Allopregnanolone Enhances GABAergic Inhibition in Spinal Motor Networks

Allopregnanolone Enhances GABAergic Inhibition in Spinal Motor Networks

The neurosteroid allopregnanolone (ALLO) causes unconsciousness by allosteric modulation of γ-aminobutyric acid type A (GABA<sub>A</sub>) receptors, but its actions on the spinal motor networks are unknown. We are therefore testing the hypothesis that ALLO attenuates the action potential...

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Bibliographic Details
Main Authors: Berthold Drexler, Julia Grenz, Christian Grasshoff, Bernd Antkowiak
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
allopregnanolone
spinal networks
electrophysiology
organotypic cultures
neuro-muscular junction
propofol
Online Access:https://www.mdpi.com/1422-0067/21/19/7399

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