The paradox of radiation and T cells in tumors
In this review we consider what appears to be a paradox in immunotherapies based around radiation therapy. The paradox is based on three main points. 1. That T cells are needed for radiation's efficacy; 2. That tumor-specific T cells are enriched in the field of treatment; and 3. That radiation...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558622000355 |
| _version_ | 1818473791420891136 |
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| author | Michael J. Gough Marka R. Crittenden |
| author_facet | Michael J. Gough Marka R. Crittenden |
| author_sort | Michael J. Gough |
| collection | DOAJ |
| description | In this review we consider what appears to be a paradox in immunotherapies based around radiation therapy. The paradox is based on three main points. 1. That T cells are needed for radiation's efficacy; 2. That tumor-specific T cells are enriched in the field of treatment; and 3. That radiation kills T cells in the treatment field. We discuss evidence of the effect of radiation on T cells in the field given their ongoing movement in and out of tissues and the tumor, and how the movement of T cells impacts the treated primary tumor and untreated distant metastases. Given this evidence, we revisit the paradox to understand how the extraordinary efficacy of radiation and immunity in preclinical models is dependent on this radiation sensitive cell. |
| first_indexed | 2024-04-14T04:28:09Z |
| format | Article |
| id | doaj.art-296a1b336c1d4173bc7adca4afddce3e |
| institution | Directory Open Access Journal |
| issn | 1476-5586 |
| language | English |
| last_indexed | 2024-04-14T04:28:09Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-296a1b336c1d4173bc7adca4afddce3e2022-12-22T02:12:11ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862022-09-0131100808The paradox of radiation and T cells in tumorsMichael J. Gough0Marka R. Crittenden1Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, 4805 NE Glisan St., Portland, OR 97213, USA; Corresponding author at: 4805 NE Glisan St., Portland, OR 97213, USA.Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, 4805 NE Glisan St., Portland, OR 97213, USA; The Oregon Clinic, Portland, OR, 97213, USAIn this review we consider what appears to be a paradox in immunotherapies based around radiation therapy. The paradox is based on three main points. 1. That T cells are needed for radiation's efficacy; 2. That tumor-specific T cells are enriched in the field of treatment; and 3. That radiation kills T cells in the treatment field. We discuss evidence of the effect of radiation on T cells in the field given their ongoing movement in and out of tissues and the tumor, and how the movement of T cells impacts the treated primary tumor and untreated distant metastases. Given this evidence, we revisit the paradox to understand how the extraordinary efficacy of radiation and immunity in preclinical models is dependent on this radiation sensitive cell.http://www.sciencedirect.com/science/article/pii/S1476558622000355 |
| spellingShingle | Michael J. Gough Marka R. Crittenden The paradox of radiation and T cells in tumors Neoplasia: An International Journal for Oncology Research |
| title | The paradox of radiation and T cells in tumors |
| title_full | The paradox of radiation and T cells in tumors |
| title_fullStr | The paradox of radiation and T cells in tumors |
| title_full_unstemmed | The paradox of radiation and T cells in tumors |
| title_short | The paradox of radiation and T cells in tumors |
| title_sort | paradox of radiation and t cells in tumors |
| url | http://www.sciencedirect.com/science/article/pii/S1476558622000355 |
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