Strong CD4 T Cell Responses to Zika Virus Antigens in a Cohort of Dengue Virus Immune Mothers of Congenital Zika Virus Syndrome Infants

Strong CD4 T Cell Responses to Zika Virus Antigens in a Cohort of Dengue Virus Immune Mothers of Congenital Zika Virus Syndrome Infants

Background: There is an urgent need to understand the complex relationship between cross-reactive anti-viral immunity, disease susceptibility, and severity in the face of differential exposure to related, circulating Flaviviruses. Co-exposure to Dengue virus and Zika virus in Brazil is a case in poi...

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Bibliographic Details
Main Authors: Catherine J. Reynolds, Patricia Watber, Camilla Natália Oliveira Santos, Danielle Rodrigues Ribeiro, Juliana Cardoso Alves, Adriana B. L. Fonseca, Ana J. B. Bispo, Roseane L. S. Porto, Kalliopi Bokea, Amélia Maria Ribeiro de Jesus, Roque Pacheco de Almeida, Rosemary J. Boyton, Daniel M. Altmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
zika virus
dengue virus
T cell epitope
flavivirus
cross-reactivity
microcephaly
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00185/full

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