Fusiform Gyrus is Related to Subclinical Social Anxiety in Healthy Individuals
Introduction Subclinical or subthreshold social anxiety (SSA) is associated with significant burden. Up to 20% of general population report subclinical social anxiety symptoms, which can change individual social, work functioning. Objectives However, neural mechanisms of SSA have not been fully inv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823004510/type/journal_article |
| _version_ | 1797616629184462848 |
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| author | B. Kim S.-H. Lee H.-J. Kim M.-K. Kim |
| author_facet | B. Kim S.-H. Lee H.-J. Kim M.-K. Kim |
| author_sort | B. Kim |
| collection | DOAJ |
| description |
Introduction
Subclinical or subthreshold social anxiety (SSA) is associated with significant burden. Up to 20% of general population report subclinical social anxiety symptoms, which can change individual social, work functioning.
Objectives
However, neural mechanisms of SSA have not been fully investigated in healthy individual yet. This study aimed to examine the relationship between gray matter volumes (GMVs) and SSA.
Methods
We enrolled a total of 57 healthy individuals with SSA. The General Anxiety Disorder-7 (GAD-7), Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and Albany Panic and Phobia Scale (APPQ) were evaluated. Freesurfer was applied to investigated the relationship between SSA and GMVs. Multiple regression models with age, sex, and total intracranial volume as covariates were performed. Pearson correlation analyses also investigated the exploratory correlations between the GMVs of the SSA-related regions and other psychological characteristics among healthy individuals.
Results
Freesurfer voxel-wise correlational analyses showed a significant negative correlation between the SA scores of APPQ and gray matter volumes (GMVs) in the fusiform gyrus (FG). In addition, the GMVs in the FG were significantly negatively associated with the total GAD-7, BDI-II, BAI, and APPQ scores. Performance anxiety was significantly correlated with posterior cingulate gyrus, parahippocampal gyrus and fusiform gyrus.
Image:
Conclusions
Our findings suggest that healthy individuals with SSA showed decreased GMVs in the FG and the GMVs of FG were associated with general anxiety and depression symptomatology.
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:43:59Z |
| format | Article |
| id | doaj.art-296be35c760142c1b1da14c4a0790673 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:43:59Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-296be35c760142c1b1da14c4a07906732023-11-17T05:07:57ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S189S18910.1192/j.eurpsy.2023.451Fusiform Gyrus is Related to Subclinical Social Anxiety in Healthy IndividualsB. Kim0S.-H. Lee1H.-J. Kim2M.-K. Kim31CHA Bundang medical center1CHA Bundang medical center1CHA Bundang medical center2CHA Ilsan medical center, Seongnam-si, Gyeonggi-do, Korea, Republic Of Introduction Subclinical or subthreshold social anxiety (SSA) is associated with significant burden. Up to 20% of general population report subclinical social anxiety symptoms, which can change individual social, work functioning. Objectives However, neural mechanisms of SSA have not been fully investigated in healthy individual yet. This study aimed to examine the relationship between gray matter volumes (GMVs) and SSA. Methods We enrolled a total of 57 healthy individuals with SSA. The General Anxiety Disorder-7 (GAD-7), Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and Albany Panic and Phobia Scale (APPQ) were evaluated. Freesurfer was applied to investigated the relationship between SSA and GMVs. Multiple regression models with age, sex, and total intracranial volume as covariates were performed. Pearson correlation analyses also investigated the exploratory correlations between the GMVs of the SSA-related regions and other psychological characteristics among healthy individuals. Results Freesurfer voxel-wise correlational analyses showed a significant negative correlation between the SA scores of APPQ and gray matter volumes (GMVs) in the fusiform gyrus (FG). In addition, the GMVs in the FG were significantly negatively associated with the total GAD-7, BDI-II, BAI, and APPQ scores. Performance anxiety was significantly correlated with posterior cingulate gyrus, parahippocampal gyrus and fusiform gyrus. Image: Conclusions Our findings suggest that healthy individuals with SSA showed decreased GMVs in the FG and the GMVs of FG were associated with general anxiety and depression symptomatology. Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823004510/type/journal_article |
| spellingShingle | B. Kim S.-H. Lee H.-J. Kim M.-K. Kim Fusiform Gyrus is Related to Subclinical Social Anxiety in Healthy Individuals European Psychiatry |
| title | Fusiform Gyrus is Related to Subclinical Social Anxiety in Healthy Individuals |
| title_full | Fusiform Gyrus is Related to Subclinical Social Anxiety in Healthy Individuals |
| title_fullStr | Fusiform Gyrus is Related to Subclinical Social Anxiety in Healthy Individuals |
| title_full_unstemmed | Fusiform Gyrus is Related to Subclinical Social Anxiety in Healthy Individuals |
| title_short | Fusiform Gyrus is Related to Subclinical Social Anxiety in Healthy Individuals |
| title_sort | fusiform gyrus is related to subclinical social anxiety in healthy individuals |
| url | https://www.cambridge.org/core/product/identifier/S0924933823004510/type/journal_article |
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