COVID-19 as a cause of chronic pulmonary hypertension: pathophysiological rationale and potential of instrumental investigations
Coronavirus disease 2019 (COVID-19) is a poorly understood and dangerous medical problem. COVID-19-related pulmonary vessels involvement is a complex set of interrelated pathophysiological processes associated with vascular endothelial dysfunction and accompanied by thrombosis of various localizatio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2021-09-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2844 |
| _version_ | 1797882310141411328 |
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| author | E. Kobelev T. A. Bergen A. R. Tarkova O. Ya. Vasiltseva O. V. Kamenskaya V. Yu. Usov A. M. Chernyavsky |
| author_facet | E. Kobelev T. A. Bergen A. R. Tarkova O. Ya. Vasiltseva O. V. Kamenskaya V. Yu. Usov A. M. Chernyavsky |
| author_sort | E. Kobelev |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) is a poorly understood and dangerous medical problem. COVID-19-related pulmonary vessels involvement is a complex set of interrelated pathophysiological processes associated with vascular endothelial dysfunction and accompanied by thrombosis of various localization, vasomotor disorders, severe respiratory failure, as well as pulmonary embolism (PE) resulting in chronic thromboembolic pulmonary hypertension (CTEPH). According to computed tomographic pulmonary angiography, the incidence of PE in patients with COVID-19 ranges from 23 to 30%. The aim of this work was to focus the doctors' attention on the risk of pulmonary hypertension in patients after COVID-19.Despite the ability of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) to infect various organs and systems, the main and most serious complications are pulmonary infiltration, acute respiratory distress syndrome, acute respiratory failure and PE, which in some cases becomes the triggering mechanism for CTEPH development. The literature review presents data on main pathological abnormalities developing in target organs during COVID-19 and playing an important role in increasing the CTEPH risk. The paper describes the main methods of instrumental investigations of CTEPH and an algorithm for its use in COVID-19 survivors.The revealed data demonstrated that the absence of obvious signs of pulmonary hypertension/CTEPH, the cardiopulmonary system abnormalities cannot be ruled out. Therefore, it seems appropriate to actively follow up COVID-19 survivors. A thoroughly, purposefully collected anamnesis, pulmonary function tests and stress echocardiography in an ambiguous clinical situation will play a leading role as they identify cardiopulmonary disorders and provide the doctor with basic information for further planning of patient management. |
| first_indexed | 2024-04-10T03:33:47Z |
| format | Article |
| id | doaj.art-296cee888f6441ada9318eabecd090f0 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:33:47Z |
| publishDate | 2021-09-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-296cee888f6441ada9318eabecd090f02023-03-13T07:23:31Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252021-09-0120510.15829/1728-8800-2021-28442319COVID-19 as a cause of chronic pulmonary hypertension: pathophysiological rationale and potential of instrumental investigationsE. Kobelev0T. A. Bergen1A. R. Tarkova2O. Ya. Vasiltseva3O. V. Kamenskaya4V. Yu. Usov5A. M. Chernyavsky6НМИЦ им. акад. Е.Н. Мешалкина Минздрава РоссииНМИЦ им. акад. Е.Н. Мешалкина Минздрава РоссииНМИЦ им. акад. Е.Н. Мешалкина Минздрава РоссииНМИЦ им. акад. Е.Н. Мешалкина Минздрава РоссииНМИЦ им. акад. Е.Н. Мешалкина Минздрава РоссииНИИ кардиологии ФГБНУ “Томский национальный исследовательский медицинский центр РАН”НМИЦ им. акад. Е.Н. Мешалкина Минздрава РоссииCoronavirus disease 2019 (COVID-19) is a poorly understood and dangerous medical problem. COVID-19-related pulmonary vessels involvement is a complex set of interrelated pathophysiological processes associated with vascular endothelial dysfunction and accompanied by thrombosis of various localization, vasomotor disorders, severe respiratory failure, as well as pulmonary embolism (PE) resulting in chronic thromboembolic pulmonary hypertension (CTEPH). According to computed tomographic pulmonary angiography, the incidence of PE in patients with COVID-19 ranges from 23 to 30%. The aim of this work was to focus the doctors' attention on the risk of pulmonary hypertension in patients after COVID-19.Despite the ability of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) to infect various organs and systems, the main and most serious complications are pulmonary infiltration, acute respiratory distress syndrome, acute respiratory failure and PE, which in some cases becomes the triggering mechanism for CTEPH development. The literature review presents data on main pathological abnormalities developing in target organs during COVID-19 and playing an important role in increasing the CTEPH risk. The paper describes the main methods of instrumental investigations of CTEPH and an algorithm for its use in COVID-19 survivors.The revealed data demonstrated that the absence of obvious signs of pulmonary hypertension/CTEPH, the cardiopulmonary system abnormalities cannot be ruled out. Therefore, it seems appropriate to actively follow up COVID-19 survivors. A thoroughly, purposefully collected anamnesis, pulmonary function tests and stress echocardiography in an ambiguous clinical situation will play a leading role as they identify cardiopulmonary disorders and provide the doctor with basic information for further planning of patient management.https://cardiovascular.elpub.ru/jour/article/view/2844легочная эмболияхроническая тромбоэмболическая легочная гипертензияcovid-19тесты с физической нагрузкойсердечно-сосудистые заболевания |
| spellingShingle | E. Kobelev T. A. Bergen A. R. Tarkova O. Ya. Vasiltseva O. V. Kamenskaya V. Yu. Usov A. M. Chernyavsky COVID-19 as a cause of chronic pulmonary hypertension: pathophysiological rationale and potential of instrumental investigations Кардиоваскулярная терапия и профилактика легочная эмболия хроническая тромбоэмболическая легочная гипертензия covid-19 тесты с физической нагрузкой сердечно-сосудистые заболевания |
| title | COVID-19 as a cause of chronic pulmonary hypertension: pathophysiological rationale and potential of instrumental investigations |
| title_full | COVID-19 as a cause of chronic pulmonary hypertension: pathophysiological rationale and potential of instrumental investigations |
| title_fullStr | COVID-19 as a cause of chronic pulmonary hypertension: pathophysiological rationale and potential of instrumental investigations |
| title_full_unstemmed | COVID-19 as a cause of chronic pulmonary hypertension: pathophysiological rationale and potential of instrumental investigations |
| title_short | COVID-19 as a cause of chronic pulmonary hypertension: pathophysiological rationale and potential of instrumental investigations |
| title_sort | covid 19 as a cause of chronic pulmonary hypertension pathophysiological rationale and potential of instrumental investigations |
| topic | легочная эмболия хроническая тромбоэмболическая легочная гипертензия covid-19 тесты с физической нагрузкой сердечно-сосудистые заболевания |
| url | https://cardiovascular.elpub.ru/jour/article/view/2844 |
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