Cobalt Protoporphyrin Blocks EqHV-8 Infection via IFN-α/β Production

Cobalt Protoporphyrin Blocks EqHV-8 Infection via IFN-α/β Production

Equid alphaherpesvirus type 8 (EqHV-8) is the causative agent of severe respiratory disease, abortions, and neurological syndromes in equines and has resulted in huge economic losses to the donkey industry. Currently, there exist no therapeutic molecules for controlling EqHV-8 infection. We evaluate...

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Bibliographic Details
Main Authors: Liangliang Li, Xinyao Hu, Shuwen Li, Ying Li, Shengmiao Zhao, Fengzhen Shen, Changfa Wang, Yubao Li, Tongtong Wang
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Animals
Subjects:
CoPP
EqHV-8
HO-1
antiviral therapeutics
Online Access:https://www.mdpi.com/2076-2615/13/17/2690
Description
Summary:Equid alphaherpesvirus type 8 (EqHV-8) is the causative agent of severe respiratory disease, abortions, and neurological syndromes in equines and has resulted in huge economic losses to the donkey industry. Currently, there exist no therapeutic molecules for controlling EqHV-8 infection. We evaluated the potential antiviral activity of cobalt protoporphyrin (CoPP) against EqHV-8 infection. Our results demonstrated that CoPP inhibited EqHV-8 infection in susceptible cells and mouse models. Furthermore, CoPP blocked the replication of EqHV-8 via HO-1 (heme oxygenase-1) mediated type I interferon (IFN) response. In conclusion, our data suggested that CoPP could serve as a novel potential molecule to develop an effective therapeutic strategy for EqHV-8 prevention and control.
ISSN:2076-2615

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