Squash Smear Cytology, CNS Lesions – Strengths and Limitations
Introduction: Cytodiagnosis of CNS Space Occupying Lesions (SOLs) by squash smear preparation is a rapid, inexpensive and fairly accurate diagnostic tool. Most of the studies till date have proved its utility in intraoperative consultation. Aim: This study was undertaken to evaluate accuracy of...
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| Format: | Article |
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JCDR Research and Publications Pvt. Ltd.
2016-07-01
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| Series: | National Journal of Laboratory Medicine |
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| Online Access: | http://www.njlm.net/articles/PDF/2125/18686_F(P)_PF1(VsuGH)_PFA(GH)_PF2(VsuGH).pdf |
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| author | Seema Acharya Sheenam Azad Sanjeev Kishore Rajnish Kumar Pankaj Arora |
| author_facet | Seema Acharya Sheenam Azad Sanjeev Kishore Rajnish Kumar Pankaj Arora |
| author_sort | Seema Acharya |
| collection | DOAJ |
| description | Introduction: Cytodiagnosis of CNS Space Occupying
Lesions (SOLs) by squash smear preparation is a rapid,
inexpensive and fairly accurate diagnostic tool. Most of
the studies till date have proved its utility in intraoperative
consultation.
Aim: This study was undertaken to evaluate accuracy of
squash smear cytology and to highlight as well as analyze
the diagnostic pitfalls.
Materials and Methods: This study was conducted in
department of pathology, Shri Guru Ram Rai Institute
of Medical and Health Sciences. Intraoperative squash
smears of two hundred and twenty two cases of CNS
SOLs were studied. Cytological diagnoses were correlated
with histopathological evaluation which was taken as gold
standard. Discordant smears were reviewed and causes
were analyzed.
Results: An accuracy of 83.78% was achieved by squash
smear cytology. The discrepancies due to interpretational
errors were seen in 61.1% cases and sampling errors
accounted for 38.9% cases. Cyto-histological discordance
was noted more in oligodendrogliomas and grading of
gliomas.
Conclusion: Squash smear cytology is a fairly reliable
diagnostic tool in intraoperative neuropathological
consultation. Thorough sampling of tissue submitted,
clinicoradiological correlation while reporting and
awareness about the diagnostic pitfalls help in achieving
reasonable accuracy |
| first_indexed | 2024-04-12T14:45:02Z |
| format | Article |
| id | doaj.art-2970ed35272d43afa6336ccbd2f68f28 |
| institution | Directory Open Access Journal |
| issn | 2277-8551 2455-6882 |
| language | English |
| last_indexed | 2024-04-12T14:45:02Z |
| publishDate | 2016-07-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | National Journal of Laboratory Medicine |
| spelling | doaj.art-2970ed35272d43afa6336ccbd2f68f282022-12-22T03:28:40ZengJCDR Research and Publications Pvt. Ltd.National Journal of Laboratory Medicine2277-85512455-68822016-07-0153PO01PO0710.7860/NJLM/2016/18686.2125Squash Smear Cytology, CNS Lesions – Strengths and LimitationsSeema Acharya 0Sheenam Azad1Sanjeev Kishore 2Rajnish Kumar3 Pankaj Arora4Professor, Department of Pathology, Shri Guru Ram Rai Institute of Medical and Health Sciencies, Dehradun, IndiaProfessor, Department of Pathology, Shri Guru Ram Rai Institute of Medical and Health Sciencies, Dehradun, India.Professor and Head, Department of Pathology, Shri Guru Ram Rai Institute of Medical and Health Sciencies, Dehradun, India.Professor, Department of Pathology, Shri Guru Ram Rai Institute of Medical and Health Sciencies, Dehradun, India.Assistant Professor, Department of Surgery, Shri Guru Ram Rai Institute of Medical and Health Sciencies, Dehradun, India.Introduction: Cytodiagnosis of CNS Space Occupying Lesions (SOLs) by squash smear preparation is a rapid, inexpensive and fairly accurate diagnostic tool. Most of the studies till date have proved its utility in intraoperative consultation. Aim: This study was undertaken to evaluate accuracy of squash smear cytology and to highlight as well as analyze the diagnostic pitfalls. Materials and Methods: This study was conducted in department of pathology, Shri Guru Ram Rai Institute of Medical and Health Sciences. Intraoperative squash smears of two hundred and twenty two cases of CNS SOLs were studied. Cytological diagnoses were correlated with histopathological evaluation which was taken as gold standard. Discordant smears were reviewed and causes were analyzed. Results: An accuracy of 83.78% was achieved by squash smear cytology. The discrepancies due to interpretational errors were seen in 61.1% cases and sampling errors accounted for 38.9% cases. Cyto-histological discordance was noted more in oligodendrogliomas and grading of gliomas. Conclusion: Squash smear cytology is a fairly reliable diagnostic tool in intraoperative neuropathological consultation. Thorough sampling of tissue submitted, clinicoradiological correlation while reporting and awareness about the diagnostic pitfalls help in achieving reasonable accuracyhttp://www.njlm.net/articles/PDF/2125/18686_F(P)_PF1(VsuGH)_PFA(GH)_PF2(VsuGH).pdfcns solsdiscordanceintraoperative cytology |
| spellingShingle | Seema Acharya Sheenam Azad Sanjeev Kishore Rajnish Kumar Pankaj Arora Squash Smear Cytology, CNS Lesions – Strengths and Limitations National Journal of Laboratory Medicine cns sols discordance intraoperative cytology |
| title | Squash Smear Cytology, CNS Lesions – Strengths and Limitations |
| title_full | Squash Smear Cytology, CNS Lesions – Strengths and Limitations |
| title_fullStr | Squash Smear Cytology, CNS Lesions – Strengths and Limitations |
| title_full_unstemmed | Squash Smear Cytology, CNS Lesions – Strengths and Limitations |
| title_short | Squash Smear Cytology, CNS Lesions – Strengths and Limitations |
| title_sort | squash smear cytology cns lesions strengths and limitations |
| topic | cns sols discordance intraoperative cytology |
| url | http://www.njlm.net/articles/PDF/2125/18686_F(P)_PF1(VsuGH)_PFA(GH)_PF2(VsuGH).pdf |
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