Enhanced efficiency of samarium-doped TiO2 nanoparticles for targeted imaging: Characterization and in vivo evaluation
Objective(s): This study aimed to synthesize Samarium-doped TiO2 nanoparticles (Ti(Sm)O2 NPs) using solvothermal synthesis and evaluate their suitability as targeted imaging agents. The objectives were to enhance the stability and biocompatibility of the nanoparticles by coating them with polymeric...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-10-01
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| Series: | Nanomedicine Journal |
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| Online Access: | https://nmj.mums.ac.ir/article_22866_4630175bdb495b7bc094de6e46cba212.pdf |
| _version_ | 1797421307811332096 |
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| author | Wesam Abd ElKader Raghda AboGabal Amr Abdelghany Ahmed Oraby |
| author_facet | Wesam Abd ElKader Raghda AboGabal Amr Abdelghany Ahmed Oraby |
| author_sort | Wesam Abd ElKader |
| collection | DOAJ |
| description | Objective(s): This study aimed to synthesize Samarium-doped TiO2 nanoparticles (Ti(Sm)O2 NPs) using solvothermal synthesis and evaluate their suitability as targeted imaging agents. The objectives were to enhance the stability and biocompatibility of the nanoparticles by coating them with polymeric materials and assess their imaging capabilities and safety. Materials and Methods: Ti(Sm)O2 NPs were synthesized using the solvothermal method with TiO2, NaOH, and deionized water. The resulting solution was filtered, dried, and processed in a Teflon-lined stainless steel autoclave. The obtained product was washed, dried, and coated with FDA-approved polymers including polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and carboxymethyl cellulose (CMC). Coating was achieved through a mixing process and subsequent drying. Results: Characterization studies confirmed the desired morphology, crystal structure, optical properties, surface charge, and biocompatibility of the Ti(Sm)O2 NPs. In vivo imaging evaluations demonstrated their excellent imaging capabilities, particularly in distinguishing lung pathologies. Additionally, in vivo toxicity studies confirmed the nanoparticles biocompatibility and safety, with no adverse effects on organ function observed. Conclusion: In this study, Samarium-doped TiO2 nanoparticles WERE successfully synthesized and their potential as targeted imaging agents was evaluated. The coating of the nanoparticles with polymeric materials enhanced their stability and biocompatibility. The nanoparticles exhibited excellent imaging capabilities, particularly in distinguishing lung pathologies. Moreover, they demonstrated biocompatibility and safety in vivo. These findings contribute to the development of advanced contrast agents for biomedical applications, providing effective tools for targeted imaging and improving the diagnosis and monitoring of various lung pathologies. |
| first_indexed | 2024-03-09T07:15:01Z |
| format | Article |
| id | doaj.art-29761733e5f84c45813c25e2706c9886 |
| institution | Directory Open Access Journal |
| issn | 2322-3049 2322-5904 |
| language | English |
| last_indexed | 2024-03-09T07:15:01Z |
| publishDate | 2023-10-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj.art-29761733e5f84c45813c25e2706c98862023-12-03T08:35:41ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042023-10-0110427929210.22038/nmj.2023.72742.178522866Enhanced efficiency of samarium-doped TiO2 nanoparticles for targeted imaging: Characterization and in vivo evaluationWesam Abd ElKader0Raghda AboGabal1Amr Abdelghany2Ahmed Oraby3Physics Department, Faculty of Science, Mansoura University, Mansoura, EgyptMansoura Urology and Nephrology Center, Mansoura University, Mansoura 35516, EgyptSpectroscopy Department, Physics Division, National Research Center, 33 ElBehouth St., Dokki, 12311, Cairo, EgyptPhysics Department, Faculty of Science, Mansoura University, Mansoura, EgyptObjective(s): This study aimed to synthesize Samarium-doped TiO2 nanoparticles (Ti(Sm)O2 NPs) using solvothermal synthesis and evaluate their suitability as targeted imaging agents. The objectives were to enhance the stability and biocompatibility of the nanoparticles by coating them with polymeric materials and assess their imaging capabilities and safety. Materials and Methods: Ti(Sm)O2 NPs were synthesized using the solvothermal method with TiO2, NaOH, and deionized water. The resulting solution was filtered, dried, and processed in a Teflon-lined stainless steel autoclave. The obtained product was washed, dried, and coated with FDA-approved polymers including polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and carboxymethyl cellulose (CMC). Coating was achieved through a mixing process and subsequent drying. Results: Characterization studies confirmed the desired morphology, crystal structure, optical properties, surface charge, and biocompatibility of the Ti(Sm)O2 NPs. In vivo imaging evaluations demonstrated their excellent imaging capabilities, particularly in distinguishing lung pathologies. Additionally, in vivo toxicity studies confirmed the nanoparticles biocompatibility and safety, with no adverse effects on organ function observed. Conclusion: In this study, Samarium-doped TiO2 nanoparticles WERE successfully synthesized and their potential as targeted imaging agents was evaluated. The coating of the nanoparticles with polymeric materials enhanced their stability and biocompatibility. The nanoparticles exhibited excellent imaging capabilities, particularly in distinguishing lung pathologies. Moreover, they demonstrated biocompatibility and safety in vivo. These findings contribute to the development of advanced contrast agents for biomedical applications, providing effective tools for targeted imaging and improving the diagnosis and monitoring of various lung pathologies.https://nmj.mums.ac.ir/article_22866_4630175bdb495b7bc094de6e46cba212.pdfbiopolymerscontrast mediadrug-related side effects and adversepolyethylene glycolssamariumtitanium dioxidex-rays |
| spellingShingle | Wesam Abd ElKader Raghda AboGabal Amr Abdelghany Ahmed Oraby Enhanced efficiency of samarium-doped TiO2 nanoparticles for targeted imaging: Characterization and in vivo evaluation Nanomedicine Journal biopolymers contrast media drug-related side effects and adverse polyethylene glycols samarium titanium dioxide x-rays |
| title | Enhanced efficiency of samarium-doped TiO2 nanoparticles for targeted imaging: Characterization and in vivo evaluation |
| title_full | Enhanced efficiency of samarium-doped TiO2 nanoparticles for targeted imaging: Characterization and in vivo evaluation |
| title_fullStr | Enhanced efficiency of samarium-doped TiO2 nanoparticles for targeted imaging: Characterization and in vivo evaluation |
| title_full_unstemmed | Enhanced efficiency of samarium-doped TiO2 nanoparticles for targeted imaging: Characterization and in vivo evaluation |
| title_short | Enhanced efficiency of samarium-doped TiO2 nanoparticles for targeted imaging: Characterization and in vivo evaluation |
| title_sort | enhanced efficiency of samarium doped tio2 nanoparticles for targeted imaging characterization and in vivo evaluation |
| topic | biopolymers contrast media drug-related side effects and adverse polyethylene glycols samarium titanium dioxide x-rays |
| url | https://nmj.mums.ac.ir/article_22866_4630175bdb495b7bc094de6e46cba212.pdf |
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