Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin

Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin

The aim of this study was to develop a formulation to improve the oral absorption of baicalin (BA) by combining a phospholipid complex (PC) and self-emulsifying microemulsion drug delivery system (SMEDDS), termed BA–PC–SMEDDS. BA–PC was prepared by a solvent evaporation method and evaluated by compl...

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Bibliographic Details
Main Authors: Huiyi Wu, Xiaoying Long, Fei Yuan, Li Chen, Sujing Pan, Yunjun Liu, Yoshiko Stowell, Xiaoling Li
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Baicalin
SMEDDS
Phospholipid complex
Caco-2 cell
Single-pass intestinal perfusion
Bioavailability
Online Access:http://www.sciencedirect.com/science/article/pii/S221138351400029X

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