Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats

Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats

Background In spontaneously hypertensive rats (SHR) we observed profound myocardial metabolic changes during early hypertension before development of cardiac dysfunction and left ventricular hypertrophy. In this study, we evaluated whether metformin improved myocardial metabolic abnormalities and si...

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Bibliographic Details
Main Authors: Jie Li, Krzysztof Minćzuk, James C. Massey, Nancy L. Howell, R. Jack Roy, Soumen Paul, James T. Patrie, Christopher M. Kramer, Frederick H. Epstein, Robert M. Carey, Heinrich Taegtmeyer, Susanna R. Keller, Bijoy K. Kundu
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac hypertrophy
cardiac MRI
dynamic FDG PET
metformin
spontaneously hypertensive rats
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.015154

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