Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project
The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action o...
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/9/3123 |
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| author | Andreas Kortenkamp Marta Axelstad Asma H. Baig Åke Bergman Carl-Gustaf Bornehag Peter Cenijn Sofie Christiansen Barbara Demeneix Arash Derakhshan Jean-Baptiste Fini Caroline Frädrich Timo Hamers Lina Hellwig Josef Köhrle Tim I.M. Korevaar Johan Lindberg Olwenn Martin Marcel E. Meima Philipp Mergenthaler Nikolai Nikolov David Du Pasquier Robin P. Peeters Bjorn Platzack Louise Ramhøj Sylvie Remaud Kostja Renko Martin Scholze Harald Stachelscheid Terje Svingen Fabian Wagenaars Eva Bay Wedebye R. Thomas Zoeller |
| author_facet | Andreas Kortenkamp Marta Axelstad Asma H. Baig Åke Bergman Carl-Gustaf Bornehag Peter Cenijn Sofie Christiansen Barbara Demeneix Arash Derakhshan Jean-Baptiste Fini Caroline Frädrich Timo Hamers Lina Hellwig Josef Köhrle Tim I.M. Korevaar Johan Lindberg Olwenn Martin Marcel E. Meima Philipp Mergenthaler Nikolai Nikolov David Du Pasquier Robin P. Peeters Bjorn Platzack Louise Ramhøj Sylvie Remaud Kostja Renko Martin Scholze Harald Stachelscheid Terje Svingen Fabian Wagenaars Eva Bay Wedebye R. Thomas Zoeller |
| author_sort | Andreas Kortenkamp |
| collection | DOAJ |
| description | The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood–brain and blood–placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation. |
| first_indexed | 2024-03-10T20:10:14Z |
| format | Article |
| id | doaj.art-2976f72e7ae84f969a63ae54ea173fd8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:10:14Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2976f72e7ae84f969a63ae54ea173fd82023-11-19T22:59:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01219312310.3390/ijms21093123Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA ProjectAndreas Kortenkamp0Marta Axelstad1Asma H. Baig2Åke Bergman3Carl-Gustaf Bornehag4Peter Cenijn5Sofie Christiansen6Barbara Demeneix7Arash Derakhshan8Jean-Baptiste Fini9Caroline Frädrich10Timo Hamers11Lina Hellwig12Josef Köhrle13Tim I.M. Korevaar14Johan Lindberg15Olwenn Martin16Marcel E. Meima17Philipp Mergenthaler18Nikolai Nikolov19David Du Pasquier20Robin P. Peeters21Bjorn Platzack22Louise Ramhøj23Sylvie Remaud24Kostja Renko25Martin Scholze26Harald Stachelscheid27Terje Svingen28Fabian Wagenaars29Eva Bay Wedebye30R. Thomas Zoeller31Institute of Environment, Health and Societies, Brunel University London, Uxbridge UB8 3PH, UKNational Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, DenmarkInstitute of Environment, Health and Societies, Brunel University London, Uxbridge UB8 3PH, UKSchool of Science and Technology, Orebro University, SE-701 82 Orebro, SwedenDepartment of Health Sciences, Karlstad University, SE-651 88 Karlstad, SwedenDepartment of Environment and Health, Vrije Universiteit Amsterdam, VUA, 1081 HV Amsterdam, The NetherlandsNational Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, DenmarkUnité PhyMA Laboratory, Adaptation du Vivant, Muséum national d’Histoire naturelle, Centre National de la Recherche Scientifique CNRS 7, rue Cuvier, F-75005 Paris, FranceDepartment of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, 3000 CA Rotterdam, The NetherlandsUnité PhyMA Laboratory, Adaptation du Vivant, Muséum national d’Histoire naturelle, Centre National de la Recherche Scientifique CNRS 7, rue Cuvier, F-75005 Paris, FranceDepartment of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, D-13353 Berlin, GermanyDepartment of Environment and Health, Vrije Universiteit Amsterdam, VUA, 1081 HV Amsterdam, The NetherlandsDept. of Experimental Neurology, Dept. of Neurology, Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, D-10117 Berlin, GermanyDepartment of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, D-13353 Berlin, GermanyDepartment of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, 3000 CA Rotterdam, The NetherlandsDepartment of C4hemical Process and Pharmaceutical Development, Research Institutes Sweden, RISE, SE-151 36 Sodertalje, SwedenInstitute of Environment, Health and Societies, Brunel University London, Uxbridge UB8 3PH, UKDepartment of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, 3000 CA Rotterdam, The NetherlandsDept. of Experimental Neurology, Dept. of Neurology, Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, D-10117 Berlin, GermanyNational Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, DenmarkLaboratoire Watchfrog, F-91000 Evry, FranceDepartment of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, 3000 CA Rotterdam, The NetherlandsDepartment of C4hemical Process and Pharmaceutical Development, Research Institutes Sweden, RISE, SE-151 36 Sodertalje, SwedenNational Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, DenmarkUnité PhyMA Laboratory, Adaptation du Vivant, Muséum national d’Histoire naturelle, Centre National de la Recherche Scientifique CNRS 7, rue Cuvier, F-75005 Paris, FranceDepartment of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, D-13353 Berlin, GermanyInstitute of Environment, Health and Societies, Brunel University London, Uxbridge UB8 3PH, UKCharité-BIH Centrum Therapy and Research, BIH Stem Cell Core Facility, Charité – Universitätsmedizin Berlin, D-13353 Berlin, GermanyNational Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, DenmarkDepartment of Environment and Health, Vrije Universiteit Amsterdam, VUA, 1081 HV Amsterdam, The NetherlandsNational Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, DenmarkSchool of Science and Technology, Orebro University, SE-701 82 Orebro, SwedenThe test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood–brain and blood–placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation.https://www.mdpi.com/1422-0067/21/9/3123endocrine disruptorsthyroid hormone systembrain developmenttest method developmenttest method validationrisk assessment |
| spellingShingle | Andreas Kortenkamp Marta Axelstad Asma H. Baig Åke Bergman Carl-Gustaf Bornehag Peter Cenijn Sofie Christiansen Barbara Demeneix Arash Derakhshan Jean-Baptiste Fini Caroline Frädrich Timo Hamers Lina Hellwig Josef Köhrle Tim I.M. Korevaar Johan Lindberg Olwenn Martin Marcel E. Meima Philipp Mergenthaler Nikolai Nikolov David Du Pasquier Robin P. Peeters Bjorn Platzack Louise Ramhøj Sylvie Remaud Kostja Renko Martin Scholze Harald Stachelscheid Terje Svingen Fabian Wagenaars Eva Bay Wedebye R. Thomas Zoeller Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project International Journal of Molecular Sciences endocrine disruptors thyroid hormone system brain development test method development test method validation risk assessment |
| title | Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project |
| title_full | Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project |
| title_fullStr | Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project |
| title_full_unstemmed | Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project |
| title_short | Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project |
| title_sort | removing critical gaps in chemical test methods by developing new assays for the identification of thyroid hormone system disrupting chemicals the athena project |
| topic | endocrine disruptors thyroid hormone system brain development test method development test method validation risk assessment |
| url | https://www.mdpi.com/1422-0067/21/9/3123 |
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