Nicotine Elevated Intracellular Ca2+ in Rat Airway Smooth Muscle Cells via Activating and Up-Regulating α7-Nicotinic Acetylcholine Receptor

Nicotine Elevated Intracellular Ca2+ in Rat Airway Smooth Muscle Cells via Activating and Up-Regulating α7-Nicotinic Acetylcholine Receptor

Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling with airway smooth muscle (ASM) hypertrophy and hyperplasia. Since tobacco use is the key risk factor for the development of COPD and intracellular Ca2+ concentration ([Ca2+]i) plays a major role in both c...

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Bibliographic Details
Main Authors: Yongliang Jiang, Aiguo Dai, Yumin Zhou, Gongyong Peng, Guoping Hu, Bing Li, James S.K. Sham, Pixin Ran
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Nicotinic acetylcholine receptors
Intracellular calcium
Airway smooth muscle cells
Nicotine
Online Access:http://www.karger.com/Article/FullText/356678

Internet

http://www.karger.com/Article/FullText/356678

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