Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen

Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen

Here, Mac Kain and Maarifi et al. perform a functional CRISPR/Cas9 screen to identify SARS-CoV-2 restriction factors in A549 cells. They identify DAXX, a scaffold protein of nuclear bodies with diverse functions, that has anti-viral activity post SARS-CoV-2 entry, while SARS-CoV-2 has evolved a mech...

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Bibliographic Details
Main Authors: Alice Mac Kain, Ghizlane Maarifi, Sophie-Marie Aicher, Nathalie Arhel, Artem Baidaliuk, Sandie Munier, Flora Donati, Thomas Vallet, Quang Dinh Tran, Alexandra Hardy, Maxime Chazal, Françoise Porrot, Molly OhAinle, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Gert Zimmer, Etienne Simon-Lorière, Timothée Bruel, Olivier Schwartz, Sylvie van der Werf, Nolwenn Jouvenet, Sébastien Nisole, Marco Vignuzzi, Ferdinand Roesch
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30134-9

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