Lower SARS-CoV-2–specific humoral immunity in people living with HIV-1 recovered from nonhospitalized COVID-19
People living with HIV-1 (PLWH) exhibit more rapid antibody decline following routine immunization and elevated baseline chronic inflammation than people without HIV-1 (PWOH), indicating potential for diminished humoral immunity during SARS-CoV-2 infection. Conflicting reports have emerged on the ab...
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| Format: | Article |
| Language: | English |
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American Society for Clinical investigation
2022-11-01
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| Series: | JCI Insight |
| Subjects: | |
| Online Access: | https://doi.org/10.1172/jci.insight.158402 |
| _version_ | 1797634347694555136 |
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| author | Daniel J. Schuster Shelly Karuna Caroline Brackett Martina Wesley Shuying S. Li Nathan Eisel DeAnna Tenney Sir’Tauria Hilliard Nicole L. Yates Jack R. Heptinstall LaTonya D. Williams Xiaoying Shen Robert Rolfe Robinson Cabello Lu Zhang Sheetal Sawant Jiani Hu April Kaur Randhawa Ollivier Hyrien John A. Hural Lawrence Corey Ian Frank Georgia D. Tomaras Kelly E. Seaton HVTN 405/HPTN 1901 Study Team |
| author_facet | Daniel J. Schuster Shelly Karuna Caroline Brackett Martina Wesley Shuying S. Li Nathan Eisel DeAnna Tenney Sir’Tauria Hilliard Nicole L. Yates Jack R. Heptinstall LaTonya D. Williams Xiaoying Shen Robert Rolfe Robinson Cabello Lu Zhang Sheetal Sawant Jiani Hu April Kaur Randhawa Ollivier Hyrien John A. Hural Lawrence Corey Ian Frank Georgia D. Tomaras Kelly E. Seaton HVTN 405/HPTN 1901 Study Team |
| author_sort | Daniel J. Schuster |
| collection | DOAJ |
| description | People living with HIV-1 (PLWH) exhibit more rapid antibody decline following routine immunization and elevated baseline chronic inflammation than people without HIV-1 (PWOH), indicating potential for diminished humoral immunity during SARS-CoV-2 infection. Conflicting reports have emerged on the ability of PLWH to maintain humoral protection against SARS-CoV-2 coinfection during convalescence. It is unknown whether peak COVID-19 severity, along with HIV-1 infection status, associates with the quality and quantity of humoral immunity following recovery. Using a cross-sectional observational cohort from the United States and Peru, adults were enrolled 1–10 weeks after SARS-CoV-2 infection diagnosis or symptom resolution. Serum antibodies were analyzed for SARS-CoV-2–specific response rates, binding magnitudes, ACE2 receptor blocking, and antibody-dependent cellular phagocytosis. Overall, (a) PLWH exhibited a trend toward decreased magnitude of SARS-CoV-2–specific antibodies, despite modestly increased overall response rates when compared with PWOH; (b) PLWH recovered from symptomatic outpatient COVID-19 had comparatively diminished immune responses; and (c) PLWH lacked a corresponding increase in SARS-CoV-2 antibodies with increased COVID-19 severity when asymptomatic versus symptomatic outpatient disease was compared. |
| first_indexed | 2024-03-11T12:06:24Z |
| format | Article |
| id | doaj.art-297bf81be35848f98a4923e358e65b11 |
| institution | Directory Open Access Journal |
| issn | 2379-3708 |
| language | English |
| last_indexed | 2024-03-11T12:06:24Z |
| publishDate | 2022-11-01 |
| publisher | American Society for Clinical investigation |
| record_format | Article |
| series | JCI Insight |
| spelling | doaj.art-297bf81be35848f98a4923e358e65b112023-11-07T16:24:47ZengAmerican Society for Clinical investigationJCI Insight2379-37082022-11-01721Lower SARS-CoV-2–specific humoral immunity in people living with HIV-1 recovered from nonhospitalized COVID-19Daniel J. SchusterShelly KarunaCaroline BrackettMartina WesleyShuying S. LiNathan EiselDeAnna TenneySir’Tauria HilliardNicole L. YatesJack R. HeptinstallLaTonya D. WilliamsXiaoying ShenRobert RolfeRobinson CabelloLu ZhangSheetal SawantJiani HuApril Kaur RandhawaOllivier HyrienJohn A. HuralLawrence CoreyIan FrankGeorgia D. TomarasKelly E. SeatonHVTN 405/HPTN 1901 Study TeamPeople living with HIV-1 (PLWH) exhibit more rapid antibody decline following routine immunization and elevated baseline chronic inflammation than people without HIV-1 (PWOH), indicating potential for diminished humoral immunity during SARS-CoV-2 infection. Conflicting reports have emerged on the ability of PLWH to maintain humoral protection against SARS-CoV-2 coinfection during convalescence. It is unknown whether peak COVID-19 severity, along with HIV-1 infection status, associates with the quality and quantity of humoral immunity following recovery. Using a cross-sectional observational cohort from the United States and Peru, adults were enrolled 1–10 weeks after SARS-CoV-2 infection diagnosis or symptom resolution. Serum antibodies were analyzed for SARS-CoV-2–specific response rates, binding magnitudes, ACE2 receptor blocking, and antibody-dependent cellular phagocytosis. Overall, (a) PLWH exhibited a trend toward decreased magnitude of SARS-CoV-2–specific antibodies, despite modestly increased overall response rates when compared with PWOH; (b) PLWH recovered from symptomatic outpatient COVID-19 had comparatively diminished immune responses; and (c) PLWH lacked a corresponding increase in SARS-CoV-2 antibodies with increased COVID-19 severity when asymptomatic versus symptomatic outpatient disease was compared.https://doi.org/10.1172/jci.insight.158402AIDS/HIVCOVID-19 |
| spellingShingle | Daniel J. Schuster Shelly Karuna Caroline Brackett Martina Wesley Shuying S. Li Nathan Eisel DeAnna Tenney Sir’Tauria Hilliard Nicole L. Yates Jack R. Heptinstall LaTonya D. Williams Xiaoying Shen Robert Rolfe Robinson Cabello Lu Zhang Sheetal Sawant Jiani Hu April Kaur Randhawa Ollivier Hyrien John A. Hural Lawrence Corey Ian Frank Georgia D. Tomaras Kelly E. Seaton HVTN 405/HPTN 1901 Study Team Lower SARS-CoV-2–specific humoral immunity in people living with HIV-1 recovered from nonhospitalized COVID-19 JCI Insight AIDS/HIV COVID-19 |
| title | Lower SARS-CoV-2–specific humoral immunity in people living with HIV-1 recovered from nonhospitalized COVID-19 |
| title_full | Lower SARS-CoV-2–specific humoral immunity in people living with HIV-1 recovered from nonhospitalized COVID-19 |
| title_fullStr | Lower SARS-CoV-2–specific humoral immunity in people living with HIV-1 recovered from nonhospitalized COVID-19 |
| title_full_unstemmed | Lower SARS-CoV-2–specific humoral immunity in people living with HIV-1 recovered from nonhospitalized COVID-19 |
| title_short | Lower SARS-CoV-2–specific humoral immunity in people living with HIV-1 recovered from nonhospitalized COVID-19 |
| title_sort | lower sars cov 2 specific humoral immunity in people living with hiv 1 recovered from nonhospitalized covid 19 |
| topic | AIDS/HIV COVID-19 |
| url | https://doi.org/10.1172/jci.insight.158402 |
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