Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease
The skin is the most common target organ affected by graft-versus-host disease (GVHD), with severity and response to therapy representing important predictors of patient survival. Although many of the initiating events in GVHD pathogenesis have been defined, less is known about why treatment resista...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00963/full |
| _version_ | 1818410091271946240 |
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| author | Pedro Santos e Sousa Pedro Santos e Sousa Clare L. Bennett Clare L. Bennett Ronjon Chakraverty Ronjon Chakraverty |
| author_facet | Pedro Santos e Sousa Pedro Santos e Sousa Clare L. Bennett Clare L. Bennett Ronjon Chakraverty Ronjon Chakraverty |
| author_sort | Pedro Santos e Sousa |
| collection | DOAJ |
| description | The skin is the most common target organ affected by graft-versus-host disease (GVHD), with severity and response to therapy representing important predictors of patient survival. Although many of the initiating events in GVHD pathogenesis have been defined, less is known about why treatment resistance occurs or why there is often a permanent failure to restore tissue homeostasis. Emerging data suggest that the unique immune microenvironment in the skin is responsible for defining location- and context-specific mechanisms of injury that are distinct from those involved in other target organs. In this review, we address recent advances in our understanding of GVHD biology in the skin and outline the new research themes that will ultimately enable design of precision therapies. |
| first_indexed | 2024-12-14T10:10:00Z |
| format | Article |
| id | doaj.art-297c024adbd84d8aa56ca78a34f3130a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T10:10:00Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-297c024adbd84d8aa56ca78a34f3130a2022-12-21T23:07:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-05-01910.3389/fimmu.2018.00963353228Unraveling the Mechanisms of Cutaneous Graft-Versus-Host DiseasePedro Santos e Sousa0Pedro Santos e Sousa1Clare L. Bennett2Clare L. Bennett3Ronjon Chakraverty4Ronjon Chakraverty5UCL Cancer Institute, University College London, London, United KingdomUCL Institute of Immunity and Transplantation, University College London, London, United KingdomUCL Cancer Institute, University College London, London, United KingdomUCL Institute of Immunity and Transplantation, University College London, London, United KingdomUCL Cancer Institute, University College London, London, United KingdomUCL Institute of Immunity and Transplantation, University College London, London, United KingdomThe skin is the most common target organ affected by graft-versus-host disease (GVHD), with severity and response to therapy representing important predictors of patient survival. Although many of the initiating events in GVHD pathogenesis have been defined, less is known about why treatment resistance occurs or why there is often a permanent failure to restore tissue homeostasis. Emerging data suggest that the unique immune microenvironment in the skin is responsible for defining location- and context-specific mechanisms of injury that are distinct from those involved in other target organs. In this review, we address recent advances in our understanding of GVHD biology in the skin and outline the new research themes that will ultimately enable design of precision therapies.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00963/fullcutaneous graft-versus-host diseasepathophysiologyT cellsantigen-presenting cellsB cellsrepair mechanisms |
| spellingShingle | Pedro Santos e Sousa Pedro Santos e Sousa Clare L. Bennett Clare L. Bennett Ronjon Chakraverty Ronjon Chakraverty Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease Frontiers in Immunology cutaneous graft-versus-host disease pathophysiology T cells antigen-presenting cells B cells repair mechanisms |
| title | Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease |
| title_full | Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease |
| title_fullStr | Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease |
| title_full_unstemmed | Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease |
| title_short | Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease |
| title_sort | unraveling the mechanisms of cutaneous graft versus host disease |
| topic | cutaneous graft-versus-host disease pathophysiology T cells antigen-presenting cells B cells repair mechanisms |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00963/full |
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