SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects

SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects

Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptiv...

Full description

Bibliographic Details
Main Authors: Wang Yating, Abolhassani Hassan, Hammarström Lennart, Pan-Hammarström Qiang
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-06-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
COVID-19
DNA repair mechanism
inborn errors of immunity
primary immunodeficiency
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022071
Description
Summary:Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptive immune system, which provides specific and long-term protection against SARS-CoV-2. This review highlights the impact of SARS-CoV-2 infections on IEI patients with DNA repair disorders and summarizes susceptibility risk factors, pathogenic mechanisms, clinical manifestations and management strategies of COVID-19 in this special patient population.
ISSN:1672-9145

Similar Items