SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects
Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptiv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2022-06-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2022071 |
| _version_ | 1797635396722491392 |
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| author | Wang Yating Abolhassani Hassan Hammarström Lennart Pan-Hammarström Qiang |
| author_facet | Wang Yating Abolhassani Hassan Hammarström Lennart Pan-Hammarström Qiang |
| author_sort | Wang Yating |
| collection | DOAJ |
| description | Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptive immune system, which provides specific and long-term protection against SARS-CoV-2. This review highlights the impact of SARS-CoV-2 infections on IEI patients with DNA repair disorders and summarizes susceptibility risk factors, pathogenic mechanisms, clinical manifestations and management strategies of COVID-19 in this special patient population. |
| first_indexed | 2024-03-11T12:20:32Z |
| format | Article |
| id | doaj.art-297c8716f1b6435cb2d06f5c914289ef |
| institution | Directory Open Access Journal |
| issn | 1672-9145 |
| language | English |
| last_indexed | 2024-03-11T12:20:32Z |
| publishDate | 2022-06-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj.art-297c8716f1b6435cb2d06f5c914289ef2023-11-07T00:58:35ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452022-06-015483684610.3724/abbs.202207120d259ccSARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defectsWang Yating0Abolhassani Hassan1Hammarström Lennart2Pan-Hammarström Qiang3[][][][]Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptive immune system, which provides specific and long-term protection against SARS-CoV-2. This review highlights the impact of SARS-CoV-2 infections on IEI patients with DNA repair disorders and summarizes susceptibility risk factors, pathogenic mechanisms, clinical manifestations and management strategies of COVID-19 in this special patient population.https://www.sciengine.com/doi/10.3724/abbs.2022071COVID-19DNA repair mechanisminborn errors of immunityprimary immunodeficiency |
| spellingShingle | Wang Yating Abolhassani Hassan Hammarström Lennart Pan-Hammarström Qiang SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects Acta Biochimica et Biophysica Sinica COVID-19 DNA repair mechanism inborn errors of immunity primary immunodeficiency |
| title | SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects |
| title_full | SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects |
| title_fullStr | SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects |
| title_full_unstemmed | SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects |
| title_short | SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects |
| title_sort | sars cov 2 infection in patients with inborn errors of immunity due to dna repair defects |
| topic | COVID-19 DNA repair mechanism inborn errors of immunity primary immunodeficiency |
| url | https://www.sciengine.com/doi/10.3724/abbs.2022071 |
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