Alzheimer's Disease: Aging, Insomnia and Epigenetics
Alzheimer's disease (AD) is the most common form of dementia. Severe memory loss, confusion, and impaired cognitive abilities characterize AD. It was only a century after Alzheimer's discovery that scientists were able to shed light on the mystery of its cause, but AD has also become a glo...
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| Format: | Article |
| Language: | English |
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Elsevier
2010-12-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S102845591060099X |
| _version_ | 1818154195476283392 |
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| author | Tzong Yuan Wu Chih-Ping Chen Tzyy-Rong Jinn |
| author_facet | Tzong Yuan Wu Chih-Ping Chen Tzyy-Rong Jinn |
| author_sort | Tzong Yuan Wu |
| collection | DOAJ |
| description | Alzheimer's disease (AD) is the most common form of dementia. Severe memory loss, confusion, and impaired cognitive abilities characterize AD. It was only a century after Alzheimer's discovery that scientists were able to shed light on the mystery of its cause, but AD has also become a globally important health issue and the treatment of AD is a challenge for modern medicine. At present, there are five drugs approved in the United States for the treatment of AD, namely, donepezil, galantamine, rivastigmine, and tacrine (which are all cholinesterase inhibitors); and memantine (which is a glutamate receptor antagonist). However, these drugs show only modest effects on AD patients. Thus, new investigations are necessary for pharmacological development in AD. This brief review focuses on new studies that demonstrate the link between epigenetics and AD, and explores the possibility that insomnia may be one factor that effects AD. |
| first_indexed | 2024-12-11T14:22:39Z |
| format | Article |
| id | doaj.art-297d23eaab3d47a3b8eb82de2690379e |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-11T14:22:39Z |
| publishDate | 2010-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-297d23eaab3d47a3b8eb82de2690379e2022-12-22T01:02:49ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592010-12-0149446847210.1016/S1028-4559(10)60099-XAlzheimer's Disease: Aging, Insomnia and EpigeneticsTzong Yuan Wu0Chih-Ping Chen1Tzyy-Rong Jinn2Department of Bioscience Technology, Chung Yuan Christian University, Chung Li, Taipei, Taichung, TaiwanDepartment of Obstetrics and Gynecology, Taipei, Taichung, TaiwanDepartment of Graduate Institute of Chinese Medical Science, China Medical University, Taichung, TaiwanAlzheimer's disease (AD) is the most common form of dementia. Severe memory loss, confusion, and impaired cognitive abilities characterize AD. It was only a century after Alzheimer's discovery that scientists were able to shed light on the mystery of its cause, but AD has also become a globally important health issue and the treatment of AD is a challenge for modern medicine. At present, there are five drugs approved in the United States for the treatment of AD, namely, donepezil, galantamine, rivastigmine, and tacrine (which are all cholinesterase inhibitors); and memantine (which is a glutamate receptor antagonist). However, these drugs show only modest effects on AD patients. Thus, new investigations are necessary for pharmacological development in AD. This brief review focuses on new studies that demonstrate the link between epigenetics and AD, and explores the possibility that insomnia may be one factor that effects AD.http://www.sciencedirect.com/science/article/pii/S102845591060099XAlzheimer's diseaseepigeneticsinsomniaorexin |
| spellingShingle | Tzong Yuan Wu Chih-Ping Chen Tzyy-Rong Jinn Alzheimer's Disease: Aging, Insomnia and Epigenetics Taiwanese Journal of Obstetrics & Gynecology Alzheimer's disease epigenetics insomnia orexin |
| title | Alzheimer's Disease: Aging, Insomnia and Epigenetics |
| title_full | Alzheimer's Disease: Aging, Insomnia and Epigenetics |
| title_fullStr | Alzheimer's Disease: Aging, Insomnia and Epigenetics |
| title_full_unstemmed | Alzheimer's Disease: Aging, Insomnia and Epigenetics |
| title_short | Alzheimer's Disease: Aging, Insomnia and Epigenetics |
| title_sort | alzheimer s disease aging insomnia and epigenetics |
| topic | Alzheimer's disease epigenetics insomnia orexin |
| url | http://www.sciencedirect.com/science/article/pii/S102845591060099X |
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