Novel bio-inspired 3D porous scaffold intended for bone-tissue engineering: Design and in silico characterisation of histomorphometric, mechanical and mass-transport properties
The design of novel biomimetic bone tissue scaffolds (BTS) using computer aided design (CAD) technology is challenging additive manufacturing technologies. At the microstructure level, BTS should mimic bone histomorphometry and assure optimum mass transport and mechanical properties. In this study,...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522010905 |
| _version_ | 1811175463966474240 |
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| author | Sergio Gómez González Maria Daniela Vlad José López López Enrique Fernández Aguado |
| author_facet | Sergio Gómez González Maria Daniela Vlad José López López Enrique Fernández Aguado |
| author_sort | Sergio Gómez González |
| collection | DOAJ |
| description | The design of novel biomimetic bone tissue scaffolds (BTS) using computer aided design (CAD) technology is challenging additive manufacturing technologies. At the microstructure level, BTS should mimic bone histomorphometry and assure optimum mass transport and mechanical properties. In this study, a novel BTS has been designed, by using a parametric and variational CAD method, to model a bio-inspired and interconnected porous structure. The mechanical (elastic modulus) and the fluid mass transport (permeability) properties have been computed and compared to other implicit surfaces modelling scaffolds. The results showed that the new BTS could be tuned during the design stage to match the microstructure and the histomorphometry properties of trabecular bone. Those with porosities between 0.7 and 0.9 and highly smooth curvatures were the most appropriates. The new BTS, once appropriately designed, could be made/manufactured by 3D printing technology with an internal microstructure mimicking the local bone properties of the selected bone volumes of interest, for example, those coming from computed tomography medical images. |
| first_indexed | 2024-04-10T19:37:24Z |
| format | Article |
| id | doaj.art-297d7c09d0ce4a27a2a610389c02d2fd |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-10T19:37:24Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-297d7c09d0ce4a27a2a610389c02d2fd2023-01-30T04:12:00ZengElsevierMaterials & Design0264-12752023-01-01225111467Novel bio-inspired 3D porous scaffold intended for bone-tissue engineering: Design and in silico characterisation of histomorphometric, mechanical and mass-transport propertiesSergio Gómez González0Maria Daniela Vlad1José López López2Enrique Fernández Aguado3Research Group of Interacting Surfaces in Bioengineering and Materials Science (InSup), Technical University of Catalonia (UPC), Avda. Diagonal, 647, 08028 Barcelona, SpainFaculty of Medical Bioengineering, “Grigore T. Popa” University of Medicine and Pharmacy from Iasi, Str. Kogălniceanu, 9-13, 700454 Iasi, Romania; TRANSCEND Research Centre, Regional Institute of Oncology, Str. G-ral Henri Mathias Berthelot, 2-4, 700483 Iasi, RomaniaResearch Group of Interacting Surfaces in Bioengineering and Materials Science (InSup), Technical University of Catalonia (UPC), Avda. Diagonal, 647, 08028 Barcelona, SpainResearch Group of Interacting Surfaces in Bioengineering and Materials Science (InSup), Technical University of Catalonia (UPC), Avda. Diagonal, 647, 08028 Barcelona, Spain; Corresponding author at: Department of Materials Science and Engineering, Technical University of Catalonia (UPC), Avda. Diagonal 647, E-08028-Barcelona, Spain.The design of novel biomimetic bone tissue scaffolds (BTS) using computer aided design (CAD) technology is challenging additive manufacturing technologies. At the microstructure level, BTS should mimic bone histomorphometry and assure optimum mass transport and mechanical properties. In this study, a novel BTS has been designed, by using a parametric and variational CAD method, to model a bio-inspired and interconnected porous structure. The mechanical (elastic modulus) and the fluid mass transport (permeability) properties have been computed and compared to other implicit surfaces modelling scaffolds. The results showed that the new BTS could be tuned during the design stage to match the microstructure and the histomorphometry properties of trabecular bone. Those with porosities between 0.7 and 0.9 and highly smooth curvatures were the most appropriates. The new BTS, once appropriately designed, could be made/manufactured by 3D printing technology with an internal microstructure mimicking the local bone properties of the selected bone volumes of interest, for example, those coming from computed tomography medical images.http://www.sciencedirect.com/science/article/pii/S0264127522010905Bone tissue engineeringPorous scaffold’s computer-aided designComputational fluid dynamicsPermeabilityTortuosityHistomorphometry |
| spellingShingle | Sergio Gómez González Maria Daniela Vlad José López López Enrique Fernández Aguado Novel bio-inspired 3D porous scaffold intended for bone-tissue engineering: Design and in silico characterisation of histomorphometric, mechanical and mass-transport properties Materials & Design Bone tissue engineering Porous scaffold’s computer-aided design Computational fluid dynamics Permeability Tortuosity Histomorphometry |
| title | Novel bio-inspired 3D porous scaffold intended for bone-tissue engineering: Design and in silico characterisation of histomorphometric, mechanical and mass-transport properties |
| title_full | Novel bio-inspired 3D porous scaffold intended for bone-tissue engineering: Design and in silico characterisation of histomorphometric, mechanical and mass-transport properties |
| title_fullStr | Novel bio-inspired 3D porous scaffold intended for bone-tissue engineering: Design and in silico characterisation of histomorphometric, mechanical and mass-transport properties |
| title_full_unstemmed | Novel bio-inspired 3D porous scaffold intended for bone-tissue engineering: Design and in silico characterisation of histomorphometric, mechanical and mass-transport properties |
| title_short | Novel bio-inspired 3D porous scaffold intended for bone-tissue engineering: Design and in silico characterisation of histomorphometric, mechanical and mass-transport properties |
| title_sort | novel bio inspired 3d porous scaffold intended for bone tissue engineering design and in silico characterisation of histomorphometric mechanical and mass transport properties |
| topic | Bone tissue engineering Porous scaffold’s computer-aided design Computational fluid dynamics Permeability Tortuosity Histomorphometry |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522010905 |
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