Iron Oxides Nanoparticles as Components of Ferroptosis-Inducing Systems: Screening of Potential Candidates
This study presents an analysis of a set of iron oxides nanoparticles (NPs) (γ-Fe<sub>2</sub>O<sub>3</sub>, α-FeOOH, δ-FeOOH, 5Fe<sub>2</sub>O<sub>3</sub>·9H<sub>2</sub>O, and Fe<sub>3</sub>O<sub>4</sub>) as potentia...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Magnetochemistry |
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| Online Access: | https://www.mdpi.com/2312-7481/9/1/3 |
| _version_ | 1827623618347008000 |
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| author | Artur Dzeranov Lyubov Bondarenko Denis Pankratov Mikhail Prokof‘ev Gulzhian Dzhardimalieva Sharipa Jorobekova Nataliya Tropskaya Ludmila Telegina Kamila Kydralieva |
| author_facet | Artur Dzeranov Lyubov Bondarenko Denis Pankratov Mikhail Prokof‘ev Gulzhian Dzhardimalieva Sharipa Jorobekova Nataliya Tropskaya Ludmila Telegina Kamila Kydralieva |
| author_sort | Artur Dzeranov |
| collection | DOAJ |
| description | This study presents an analysis of a set of iron oxides nanoparticles (NPs) (γ-Fe<sub>2</sub>O<sub>3</sub>, α-FeOOH, δ-FeOOH, 5Fe<sub>2</sub>O<sub>3</sub>·9H<sub>2</sub>O, and Fe<sub>3</sub>O<sub>4</sub>) as potential candidates for ferroptosis therapy in terms of a phase state, magnetic characteristics, and the release of Fe<sup>2+/</sup>Fe<sup>3+</sup> as ROS mediators. Due to the values of saturation magnetization for Fe<sub>3</sub>O<sub>4</sub> (31.6 emu/g) and γ-Fe<sub>2</sub>O<sub>3</sub> (33.8 emu/g), as well as the surface area of these particles (130 and 123 m<sup>2</sup>/g), it is possible to consider them as promising magnetically controlled carriers that can function with various ligands. The evaluation of the release of Fe<sup>2+</sup>/Fe<sup>3+</sup> ions as catalysts for the Fenton reaction showed that the concentration of the released ions increases within first 3 h after suspension and decreases within 24 h, which probably indicates desorption and adsorption of ions from/onto the surface of nanoparticles regardless their nature. The concentration of ions released by all nanoparticles, except α-FeOOH-Fe<sup>2+</sup>, reached 9.1 mg/L for Fe<sup>3+</sup> to 1.7 mg/L for Fe<sup>2+</sup>, which makes them preferable for controlling the catalysis of the Fenton reaction. In contrast, a high concentration of iron ions to 90 mg/L for Fe<sup>3+</sup> and 316 mg/L for Fe<sup>2+</sup> released from compound α-FeOOH-Fe<sup>2+</sup> allows us to utilize this oxide as an aid therapy agent. Results obtained on iron oxide nanoparticles will provide data for the most prospective candidates that are used in ferroptosis-inducing systems. |
| first_indexed | 2024-03-09T11:53:11Z |
| format | Article |
| id | doaj.art-297d9b163cda40a3b485b9e0868535a4 |
| institution | Directory Open Access Journal |
| issn | 2312-7481 |
| language | English |
| last_indexed | 2024-03-09T11:53:11Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Magnetochemistry |
| spelling | doaj.art-297d9b163cda40a3b485b9e0868535a42023-11-30T23:12:17ZengMDPI AGMagnetochemistry2312-74812022-12-0191310.3390/magnetochemistry9010003Iron Oxides Nanoparticles as Components of Ferroptosis-Inducing Systems: Screening of Potential CandidatesArtur Dzeranov0Lyubov Bondarenko1Denis Pankratov2Mikhail Prokof‘ev3Gulzhian Dzhardimalieva4Sharipa Jorobekova5Nataliya Tropskaya6Ludmila Telegina7Kamila Kydralieva8Moscow Aviation Institute (National Research University), Moscow 125993, RussiaMoscow Aviation Institute (National Research University), Moscow 125993, RussiaDepartment of Chemistry, Lomonosov Moscow State University, Moscow 119991, RussiaMoscow Aviation Institute (National Research University), Moscow 125993, RussiaMoscow Aviation Institute (National Research University), Moscow 125993, RussiaInstitute of Chemistry and Phytotechnologies, National Academy of Sciences, Bishkek 720071, KyrgyzstanMoscow Aviation Institute (National Research University), Moscow 125993, RussiaRussian Institute for Scientific and Technical Information, Moscow 125190, RussiaMoscow Aviation Institute (National Research University), Moscow 125993, RussiaThis study presents an analysis of a set of iron oxides nanoparticles (NPs) (γ-Fe<sub>2</sub>O<sub>3</sub>, α-FeOOH, δ-FeOOH, 5Fe<sub>2</sub>O<sub>3</sub>·9H<sub>2</sub>O, and Fe<sub>3</sub>O<sub>4</sub>) as potential candidates for ferroptosis therapy in terms of a phase state, magnetic characteristics, and the release of Fe<sup>2+/</sup>Fe<sup>3+</sup> as ROS mediators. Due to the values of saturation magnetization for Fe<sub>3</sub>O<sub>4</sub> (31.6 emu/g) and γ-Fe<sub>2</sub>O<sub>3</sub> (33.8 emu/g), as well as the surface area of these particles (130 and 123 m<sup>2</sup>/g), it is possible to consider them as promising magnetically controlled carriers that can function with various ligands. The evaluation of the release of Fe<sup>2+</sup>/Fe<sup>3+</sup> ions as catalysts for the Fenton reaction showed that the concentration of the released ions increases within first 3 h after suspension and decreases within 24 h, which probably indicates desorption and adsorption of ions from/onto the surface of nanoparticles regardless their nature. The concentration of ions released by all nanoparticles, except α-FeOOH-Fe<sup>2+</sup>, reached 9.1 mg/L for Fe<sup>3+</sup> to 1.7 mg/L for Fe<sup>2+</sup>, which makes them preferable for controlling the catalysis of the Fenton reaction. In contrast, a high concentration of iron ions to 90 mg/L for Fe<sup>3+</sup> and 316 mg/L for Fe<sup>2+</sup> released from compound α-FeOOH-Fe<sup>2+</sup> allows us to utilize this oxide as an aid therapy agent. Results obtained on iron oxide nanoparticles will provide data for the most prospective candidates that are used in ferroptosis-inducing systems.https://www.mdpi.com/2312-7481/9/1/3ferroptosis-inducing systemsiron oxide nanoparticlesphase statespecific surfacemagnetic propertiesferrous and ferric ions release |
| spellingShingle | Artur Dzeranov Lyubov Bondarenko Denis Pankratov Mikhail Prokof‘ev Gulzhian Dzhardimalieva Sharipa Jorobekova Nataliya Tropskaya Ludmila Telegina Kamila Kydralieva Iron Oxides Nanoparticles as Components of Ferroptosis-Inducing Systems: Screening of Potential Candidates Magnetochemistry ferroptosis-inducing systems iron oxide nanoparticles phase state specific surface magnetic properties ferrous and ferric ions release |
| title | Iron Oxides Nanoparticles as Components of Ferroptosis-Inducing Systems: Screening of Potential Candidates |
| title_full | Iron Oxides Nanoparticles as Components of Ferroptosis-Inducing Systems: Screening of Potential Candidates |
| title_fullStr | Iron Oxides Nanoparticles as Components of Ferroptosis-Inducing Systems: Screening of Potential Candidates |
| title_full_unstemmed | Iron Oxides Nanoparticles as Components of Ferroptosis-Inducing Systems: Screening of Potential Candidates |
| title_short | Iron Oxides Nanoparticles as Components of Ferroptosis-Inducing Systems: Screening of Potential Candidates |
| title_sort | iron oxides nanoparticles as components of ferroptosis inducing systems screening of potential candidates |
| topic | ferroptosis-inducing systems iron oxide nanoparticles phase state specific surface magnetic properties ferrous and ferric ions release |
| url | https://www.mdpi.com/2312-7481/9/1/3 |
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