Proanthocyanidins-loaded complex coacervates-based drug delivery attenuates oral squamous cell carcinoma cells metastatic potential through down-regulating the Akt signaling pathway

Proanthocyanidins-loaded complex coacervates-based drug delivery attenuates oral squamous cell carcinoma cells metastatic potential through down-regulating the Akt signaling pathway

Oral cancer, constituted up to 90% by squamous cell carcinomas, is a significant health burden globally. Grape seed proanthocyanidins (PA) have been suggested as a potential chemopreventive agent for oral cancer. However, their efficacy can be restricted due to the low bioavailability and bioaccessi...

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Bibliographic Details
Main Authors: Ju-Fang Liu, Yinshen Wee, Shen-Dean Luo, Shwu-Fen Chang, Shihai Jia, Sheng-Wei Feng, Huei-Mei Huang, Jiann-Her Lin, Ching-Shuen Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
complex coacervates
novel drug carrier
grape seed proanthocyanidins
chemopreventive agent
oral squamous cell carcinoma
protein kinase B
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1001126/full

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