Alterations of in vivo CA1 network activity in Dp(16)1Yey Down syndrome model mice

Alterations of in vivo CA1 network activity in Dp(16)1Yey Down syndrome model mice

Down syndrome, the leading genetic cause of intellectual disability, results from an extra-copy of chromosome 21. Mice engineered to model this aneuploidy exhibit Down syndrome-like memory deficits in spatial and contextual tasks. While abnormal neuronal function has been identified in these models,...

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Bibliographic Details
Main Authors: Matthieu Raveau, Denis Polygalov, Roman Boehringer, Kenji Amano, Kazuhiro Yamakawa, Thomas J McHugh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
hippocampus
Down syndrome
place cell
ripples
Online Access:https://elifesciences.org/articles/31543

Internet

https://elifesciences.org/articles/31543

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