Association of serum brain‐derived neurotrophic factor level and early response to antipsychotic drug in first‐episode patients with schizophrenia
Abstract Objectives To investigate the role of Brain derived neurotrophic factor (BDNF) in the psychotic symptoms in first‐episode patients with schizophrenia and whether BDNF levels were associated with the improvement of psychotic symptoms after risperidone treatment. Methods 89 schizophrenia pati...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | International Journal of Methods in Psychiatric Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mpr.1982 |
| _version_ | 1797238942081220608 |
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| author | Tong Zhao SuFang Tang XiaoLei Gao Juan Li Ran Hao HaiZhi Chen GuangBiao Huang |
| author_facet | Tong Zhao SuFang Tang XiaoLei Gao Juan Li Ran Hao HaiZhi Chen GuangBiao Huang |
| author_sort | Tong Zhao |
| collection | DOAJ |
| description | Abstract Objectives To investigate the role of Brain derived neurotrophic factor (BDNF) in the psychotic symptoms in first‐episode patients with schizophrenia and whether BDNF levels were associated with the improvement of psychotic symptoms after risperidone treatment. Methods 89 schizophrenia patients and 90 healthy controls were recruited, the schizophrenia patients were assigned into early response or early non‐response groups at 2 weeks based on improvement in the positive and negative symptoms scale (PANSS) total score. All patients were treated with risperidone for 2 weeks, their serum BDNF levels were compared at baseline and after 2 weeks treatment. Results We found that patients had lower BDNF levels, compared to controls at baseline. After 2 weeks of treatment of risperidone, BDNF levels were significantly increased and psychotic symptoms were decreased in early response group. Correlation analysis showed that the change of BDNF levels after treatment was correlated with the change of PANSS total score. Further regression analysis showed that the change in BDNF levels was an independent predictor for the improvement in psychotic symptoms. Conclusions Our findings reveal that the level of BDNF was lower in first‐episode schizophrenic patients, moreover, the changes in serum BDNF levels may have a predictive effect on the early improvement in psychotic symptoms in the first 2 weeks. |
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| format | Article |
| id | doaj.art-2981ff48bf1e4b5c8b0a3c9a7bf391c0 |
| institution | Directory Open Access Journal |
| issn | 1049-8931 1557-0657 |
| language | English |
| last_indexed | 2024-04-24T17:43:39Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Methods in Psychiatric Research |
| spelling | doaj.art-2981ff48bf1e4b5c8b0a3c9a7bf391c02024-03-27T15:10:42ZengWileyInternational Journal of Methods in Psychiatric Research1049-89311557-06572024-03-01331n/an/a10.1002/mpr.1982Association of serum brain‐derived neurotrophic factor level and early response to antipsychotic drug in first‐episode patients with schizophreniaTong Zhao0SuFang Tang1XiaoLei Gao2Juan Li3Ran Hao4HaiZhi Chen5GuangBiao Huang6Department of Psychiatry QuZhou Third Municipal Hospital QuZhou ChinaDepartment of Psychiatry Huzhou Third Municipal Hospital The Affiliated Hospital of Huzhou University Huzhou ChinaSchool of Nursing Xinxiang Medical University Xinxiang Henan ChinaDepartment of Psychiatry The Second Affiliated Hospital of Xinxiang Medical University Xinxiang Henan ChinaThe First Affiliated Hospital of Xinxiang Medical University Xinxiang Henan ChinaDepartment of Psychiatry Huzhou Third Municipal Hospital The Affiliated Hospital of Huzhou University Huzhou ChinaDepartment of Psychiatry Huzhou Third Municipal Hospital The Affiliated Hospital of Huzhou University Huzhou ChinaAbstract Objectives To investigate the role of Brain derived neurotrophic factor (BDNF) in the psychotic symptoms in first‐episode patients with schizophrenia and whether BDNF levels were associated with the improvement of psychotic symptoms after risperidone treatment. Methods 89 schizophrenia patients and 90 healthy controls were recruited, the schizophrenia patients were assigned into early response or early non‐response groups at 2 weeks based on improvement in the positive and negative symptoms scale (PANSS) total score. All patients were treated with risperidone for 2 weeks, their serum BDNF levels were compared at baseline and after 2 weeks treatment. Results We found that patients had lower BDNF levels, compared to controls at baseline. After 2 weeks of treatment of risperidone, BDNF levels were significantly increased and psychotic symptoms were decreased in early response group. Correlation analysis showed that the change of BDNF levels after treatment was correlated with the change of PANSS total score. Further regression analysis showed that the change in BDNF levels was an independent predictor for the improvement in psychotic symptoms. Conclusions Our findings reveal that the level of BDNF was lower in first‐episode schizophrenic patients, moreover, the changes in serum BDNF levels may have a predictive effect on the early improvement in psychotic symptoms in the first 2 weeks.https://doi.org/10.1002/mpr.1982antipsychotic drugsbrain‐derived neurotrophic factorpsychotic symptomsrisperidoneschizophrenia |
| spellingShingle | Tong Zhao SuFang Tang XiaoLei Gao Juan Li Ran Hao HaiZhi Chen GuangBiao Huang Association of serum brain‐derived neurotrophic factor level and early response to antipsychotic drug in first‐episode patients with schizophrenia International Journal of Methods in Psychiatric Research antipsychotic drugs brain‐derived neurotrophic factor psychotic symptoms risperidone schizophrenia |
| title | Association of serum brain‐derived neurotrophic factor level and early response to antipsychotic drug in first‐episode patients with schizophrenia |
| title_full | Association of serum brain‐derived neurotrophic factor level and early response to antipsychotic drug in first‐episode patients with schizophrenia |
| title_fullStr | Association of serum brain‐derived neurotrophic factor level and early response to antipsychotic drug in first‐episode patients with schizophrenia |
| title_full_unstemmed | Association of serum brain‐derived neurotrophic factor level and early response to antipsychotic drug in first‐episode patients with schizophrenia |
| title_short | Association of serum brain‐derived neurotrophic factor level and early response to antipsychotic drug in first‐episode patients with schizophrenia |
| title_sort | association of serum brain derived neurotrophic factor level and early response to antipsychotic drug in first episode patients with schizophrenia |
| topic | antipsychotic drugs brain‐derived neurotrophic factor psychotic symptoms risperidone schizophrenia |
| url | https://doi.org/10.1002/mpr.1982 |
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