Osteopontin (OPN/SPP1), a Mediator of Tumor Progression, Is Regulated by the Mesenchymal Transcription Factor Slug/SNAI2 in Colorectal Cancer (CRC)

Osteopontin (OPN/SPP1), a Mediator of Tumor Progression, Is Regulated by the Mesenchymal Transcription Factor Slug/SNAI2 in Colorectal Cancer (CRC)

In colorectal cancer (CRC), disease-related death is closely linked to tumor aggressiveness and metastasis. Gene expression profiling of patient tumors has suggested that a more mesenchymal phenotype, present in about one-fourth of all patients, is associated with increased aggressiveness. According...

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Bibliographic Details
Main Authors: Katyana Amilca-Seba, Tuan Zea Tan, Jean-Paul Thiery, Lila Louadj, Sandrine Thouroude, Anaïs Bouygues, Michèle Sabbah, Annette K. Larsen, Jérôme A. Denis
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
colorectal cancer (CRC)
epithelial–mesenchymal transition (EMT)
Slug/<i>SNAI2</i> transcription factor
osteopontin (OPN/SPP1)
Online Access:https://www.mdpi.com/2073-4409/11/11/1808

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